DRSC/TRiP Functional Genomics Resources

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Protein Alignment INSR and drl

DIOPT Version :10

Sequence 1:NP_000199.2 Gene:INSR / 3643 HGNCID:6091 Length:1382 Species:Homo sapiens
Sequence 2:NP_001260566.1 Gene:drl / 44355 FlyBaseID:FBgn0015380 Length:645 Species:Drosophila melanogaster


Alignment Length:611 Identity:142/611 - (23%)
Similarity:252/611 - (41%) Gaps:137/611 - (22%)


- Green bases have known domain annotations that are detailed below.


Human   766 DVGNVTVAVPTVAAFPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTP 830
            ::.:||....::...|...|.::.||..|      |:.:..|.||.:              .|.|
  Fly    63 NISDVTFTWQSLVDHPLPYSINIATSDTE------VLPRPILNISRI--------------GDVP 107

Human   831 EE--------RCSVA--AYVSARTMPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYE 885
            .|        :||..  |.|:.....|...|......|:.||:...:.|..::           :
  Fly   108 VEPQTWGIALKCSGTRNAEVTVTINVEVILDRATNNNTNLIFKRKKICLREEQ-----------D 161

Human   886 VSYRRYGDEELHL---------------------CVSRKHFALERGCRLRGLSP---GNYSVRIR 926
            .::..|.|::|.|                     .|:..|.|.|:...:...||   ||      
  Fly   162 SAHEEYDDDDLDLLQTARKGHGGDIHYVDRNDEHVVANGHQAPEKQRPVVTESPVGRGN------ 220

Human   927 ATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSIYLFL--RKRQPDGPLG 989
                 ..||..:.......:.:...|.:..:|:|.::.:.|.|.:|...|...  .||.|...:.
  Fly   221 -----SGGSKRDFDPMLRENLVPPASGLVTLIVGGILALVLVSTLILIAYCAKGPSKRHPSNGVH 280

Human   990 PLYASSNPEYLSASDVFPCSVYV----------------------PDEWE-------VSREKITL 1025
            .:..||.....:.|.....|:||                      |:|:.       |.:.::.|
  Fly   281 LIKTSSFQRLPTISSTAHNSIYVCPSTITPTYATLTRPFREYEHEPEEFNRRLQELTVQKCRVRL 345

Human  1026 LRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCH-HVVRL 1089
            ...:.:|:||.:|.|...|.      ..|.||||.:.|| :.::..|.:.|:|.....| :|:.:
  Fly   346 SCLVQEGNFGRIYRGTYNDC------QEVLVKTVAQHAS-QLQVNLLLQESMMLYEASHPNVLSV 403

Human  1090 LGVVSKGQPTLVVMELMAHG---DLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLN 1151
            ||:..:...|..|: ..|.|   :|||:|:      :.:..|...|:|.:: |.:::|..|.:|:
  Fly   404 LGISIEDYATPFVL-YAATGSVRNLKSFLQ------DPSYARSVTTIQTVL-MGSQLAMAMEHLH 460

Human  1152 AKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTS 1216
            ....:|:|:|||||::.....||:.|..::||::..||...|.....|::|::.|:|:...:...
  Fly   461 NHGVIHKDIAARNCVIDDQLRVKLTDSALSRDLFPGDYNSLGDGEYRPIKWLSLEALQKSHYNEG 525

Human  1217 SDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRP 1281
            ||:|||||::||:.:|.:.||..:...::..::.||..|.||.|||:.:..:|..||...|..||
  Fly   526 SDVWSFGVLMWEMCTLGKLPYAEIDPYEMEHYLKDGYRLAQPFNCPDELFTIMAYCWASMPAERP 590

Human  1282 TFLEIVNLLKDDLHPSFPEVSFFHSE 1307
            :|.::...|.:           ||::
  Fly   591 SFSQLQICLSE-----------FHTQ 605

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INSRNP_000199.2 Recep_L_domain 52..164 CDD:460032
Furin-like 179..337 CDD:395614
Recep_L_domain 359..472 CDD:460032
FN3 <582..>658 CDD:442628
FN3 622..>665 CDD:238020
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..708
Insulin-binding 733..741
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 746..766 142/611 (23%)
FN3 867..944 CDD:238020 15/100 (15%)
Insulin_TMD 940..987 CDD:465543 10/48 (21%)
PTKc_InsR 1016..1303 CDD:133192 84/297 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1382
PIK3R1-binding 1361..1364
drlNP_001260566.1 WIF 21..157 CDD:128745 23/113 (20%)
PTK_Ryk 336..606 CDD:270639 86/296 (29%)
Blue background indicates that the domain is not in the aligned region.

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