Sequence 1: | NP_000199.2 | Gene: | INSR / 3643 | HGNCID: | 6091 | Length: | 1382 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_524625.3 | Gene: | Eph / 43803 | FlyBaseID: | FBgn0025936 | Length: | 1096 | Species: | Drosophila melanogaster |
Alignment Length: | 1067 | Identity: | 268/1067 - (25%) |
---|---|---|---|
Similarity: | 417/1067 - (39%) | Gaps: | 291/1067 - (27%) |
- Green bases have known domain annotations that are detailed below.
Human 394 YLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNL--TITQGKLFFH 456
Human 457 YNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNG------DQASCENEL-LKFSYIRTSFDKILL 514
Human 515 RWEPYWPPDFRDLLGFMLFYKEAPY-QNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGW 578
Human 579 LMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATN-------------PSV----PL 626
Human 627 DPISVSNSSSQIILK-----------------WKPPSDPNGNITHYLVFWERQAEDSELFELDYC 674
Human 675 LKGLKLPSRTWSPP-----FESEDSQK--HNQSEYEDSAGECCSC-------PKTDS-----QIL 720
Human 721 KELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSS 785
Human 786 TSVPTSPEEHR--PFEKVVNKESLVISGLRHFTGYRIELQA-CNQDTPEERCSVAAYVSARTMPE 847
Human 848 AKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCR 912
Human 913 LRGLSPG-NYSVRIRATSLAGNGSWTEPTYFYV--------TDYLDVPSNIAKIIIGPLIFVFLF 968
Human 969 SVVIGSIYLFLRKRQPDG---------PLGPLYASSNPEYL--------------------SASD 1004
Human 1005 VFPCSVYVPDE------WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESA 1063
Human 1064 SLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGR 1128
Human 1129 PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETD--YYR 1191
Human 1192 KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD 1256
Human 1257 QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDL----------HPSFPEVSFFHSEENKA 1311
Human 1312 PESEELEMEFEDMENVPLDRSSHCQRE 1338 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
INSR | NP_000199.2 | Recep_L_domain | 52..164 | CDD:279382 | |
Furin-like | 179..337 | CDD:279142 | |||
FU | 234..281 | CDD:238021 | |||
Recep_L_domain | 359..472 | CDD:279382 | 17/79 (22%) | ||
FN3 | 622..>665 | CDD:238020 | 13/63 (21%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 686..708 | 8/28 (29%) | |||
Insulin-binding | 733..741 | 1/7 (14%) | |||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 746..766 | 3/19 (16%) | |||
FN3 | 867..944 | CDD:238020 | 18/77 (23%) | ||
PTKc_InsR | 1016..1303 | CDD:133192 | 119/298 (40%) | ||
Pkinase_Tyr | 1023..1290 | CDD:285015 | 111/268 (41%) | ||
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 1360..1382 | ||||
PIK3R1-binding | 1361..1364 | ||||
Eph | NP_524625.3 | EphR_LBD | 85..260 | CDD:198439 | 28/120 (23%) |
FN3 | 387..476 | CDD:238020 | 26/121 (21%) | ||
FN3 | 536..623 | CDD:238020 | 23/126 (18%) | ||
EphA2_TM | 644..736 | CDD:291255 | 18/94 (19%) | ||
PTKc_EphR | 736..1002 | CDD:270629 | 113/277 (41%) | ||
Pkinase_Tyr | 741..999 | CDD:285015 | 111/268 (41%) | ||
SAM_1 | 1033..1092 | CDD:278937 | 4/23 (17%) | ||
SAM | 1039..1092 | CDD:197735 | 4/17 (24%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 0 | 0.000 | Not matched by this tool. | |||
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 1 | 0.910 | - | - | ||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
1 | 0.910 |