DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment INSR and Eph

DIOPT Version :9

Sequence 1:NP_000199.2 Gene:INSR / 3643 HGNCID:6091 Length:1382 Species:Homo sapiens
Sequence 2:NP_524625.3 Gene:Eph / 43803 FlyBaseID:FBgn0025936 Length:1096 Species:Drosophila melanogaster


Alignment Length:1067 Identity:268/1067 - (25%)
Similarity:417/1067 - (39%) Gaps:291/1067 - (27%)


- Green bases have known domain annotations that are detailed below.


Human   394 YLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNL--TITQGKLFFH 456
            |::|:  :.:...|.|....|...||..:..|.|.|...:  ...|....:.|  .|..|:..|:
  Fly   157 YIEIQ--FTIRDCSLFPGNALSCKETFSLLFYEFDAATRE--PPPWQTDSYRLIARIAAGEGRFN 217

Human   457 YNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNG------DQASCENEL-LKFSYIRTSFDKILL 514
            .|     |::....||         ..||:...|      ||.:|.:.| :|..||..       
  Fly   218 QN-----SDVDINTEV---------KSIAVNKKGVYFAFRDQGACISVLAVKVYYITC------- 261

Human   515 RWEPYWPPDFRDLLGFMLFYKEAPY-QNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGW 578
               |....:|       ..:.|.|. :.:|..:.|:.      |.||...|..:        |.:
  Fly   262 ---PAVTENF-------AHFNETPTGREITIIEKQNG------TCVDNAEPYET--------PTY 302

Human   579 LMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATN-------------PSV----PL 626
            |.:|...||..               |.|.:....| :.:.||             |.|    |.
  Fly   303 LCKGDGKWTIL---------------TGGCRCKAGY-EPNYTNKTCTECPLGTFKSPEVTKCTPC 351

Human   627 DPISVSNSSSQIILK-----------------WKPPSDPNGNITHYLVFWERQAEDSELFELDYC 674
            .|.|.::.:.....|                 :.||:.|. |:|  |:|.:   :.|.:.     
  Fly   352 PPNSNASKTGSPFCKCASGFYRHPNDGRHMPCYSPPAAPT-NLT--LLFVD---QTSAII----- 405

Human   675 LKGLKLPSRTWSPP-----FESEDSQK--HNQSEYEDSAGECCSC-------PKTDS-----QIL 720
                     :||.|     |.||.:.|  |:...|:.   :|..|       |.||:     ..|
  Fly   406 ---------SWSAPAKNESFSSETNSKIYHSDIVYKI---KCNICSPNVVYNPSTDTFNETKITL 458

Human   721 KELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTSS 785
            ..||..:   |:...:|.:       :|.:...:.:......||       |||..: .|.|||.
  Fly   459 TNLEPVT---TYTVQIHAI-------NSVSHINEFKRHSNESSL-------VAVSDI-VFSNTSL 505

Human   786 TSVPTSPEEHR--PFEKVVNKESLVISGLRHFTGYRIELQA-CNQDTPEERCSVAAYVSARTMPE 847
            .::|....|.:  ..|.|...||:::|     |.:.:.:.| .|:|                   
  Fly   506 LNIPLDLNEVKTGQAEIVFTTESVLLS-----TVFNLRILAITNKD------------------- 546

Human   848 AKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGCR 912
              ||                 |.|.:|.:.:..:..|||  |.:...||...........|....
  Fly   547 --AD-----------------LEWDKPVQSDFPLEFYEV--RWFPKVELDAINKSALNTKETKAH 590

Human   913 LRGLSPG-NYSVRIRATSLAGNGSWTEPTYFYV--------TDYLDVPSNIAKIIIGPLIFVFLF 968
            :.||... .|..::|..:..|.||::...|...        .|.:.: ..||..|:..::|:.:|
  Fly   591 IVGLLENTEYGFQVRCKTNNGFGSYSNMIYAQTLQSVGSVYDDSVQI-RFIAGAIVTGVLFLVIF 654

Human   969 SVVIGSIYLFLRKRQPDG---------PLGPLYASSNPEYL--------------------SASD 1004
              :|.::| |:|.:..|.         ||...|||:....:                    |.|.
  Fly   655 --IIATVY-FMRSKHQDDLDKKSTNHLPLPLDYASNEVNSMDTTPIVKKLHLNVTTPLFGNSRSY 716

Human  1005 VFPCSVYVPDE------WEVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESA 1063
            |.|.:...|::      .|:....||:...:|.|.||.|..|..:.......:..||:||:...:
  Fly   717 VDPHTYEDPNQAIREFAREIDANYITIEAIIGGGEFGDVCRGRLKIPPNFVQDIDVAIKTLKPGS 781

Human  1064 SLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGR 1128
            |.:.|.:||.|||:|..|...:|:.|.|||::..|.:::.|.|.:|.|.::||.       |.|:
  Fly   782 SEKARCDFLTEASIMGQFDHPNVIYLQGVVTRSNPVMIITEYMENGSLDTFLRV-------NDGK 839

Human  1129 PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETD--YYR 1191
             ..||| :|.|...||.||:||:...:|||||||||.:|......||.|||::|:|....  |..
  Fly   840 -FQTLQ-LIVMLRGIASGMSYLSDMNYVHRDLAARNVLVNAQLICKIADFGLSREIENASDAYTT 902

Human  1192 KGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLD 1256
            :|||  :||||.|||::....||::||:||:||||||:.|..|:||...||:.|:|.:..|..|.
  Fly   903 RGGK--IPVRWTAPEAIAFRKFTSASDVWSYGVVLWEVMSYGERPYWNWSNQDVIKSIEKGYRLP 965

Human  1257 QPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDL----------HPSFPEVSFFHSEENKA 1311
            .|.:|||.:..||..|||.....||||..||:.| |:|          .|| ||....|..:.:.
  Fly   966 APMDCPEALYQLMLDCWQKQRTHRPTFASIVSTL-DNLARQPQSLLTTRPS-PESDGNHILDGQR 1028

Human  1312 PESEELEMEFEDMENVPLDRSSHCQRE 1338
            .::..:..:.. :|::.:.|..|..:|
  Fly  1029 GQNIFISTDLW-LEHIKMSRYCHHFKE 1054

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INSRNP_000199.2 Recep_L_domain 52..164 CDD:279382
Furin-like 179..337 CDD:279142
FU 234..281 CDD:238021
Recep_L_domain 359..472 CDD:279382 17/79 (22%)
FN3 622..>665 CDD:238020 13/63 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..708 8/28 (29%)
Insulin-binding 733..741 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 746..766 3/19 (16%)
FN3 867..944 CDD:238020 18/77 (23%)
PTKc_InsR 1016..1303 CDD:133192 119/298 (40%)
Pkinase_Tyr 1023..1290 CDD:285015 111/268 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1382
PIK3R1-binding 1361..1364
EphNP_524625.3 EphR_LBD 85..260 CDD:198439 28/120 (23%)
FN3 387..476 CDD:238020 26/121 (21%)
FN3 536..623 CDD:238020 23/126 (18%)
EphA2_TM 644..736 CDD:291255 18/94 (19%)
PTKc_EphR 736..1002 CDD:270629 113/277 (41%)
Pkinase_Tyr 741..999 CDD:285015 111/268 (41%)
SAM_1 1033..1092 CDD:278937 4/23 (17%)
SAM 1039..1092 CDD:197735 4/17 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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