DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment INSR and InR

DIOPT Version :10

Sequence 1:NP_000199.2 Gene:INSR / 3643 HGNCID:6091 Length:1382 Species:Homo sapiens
Sequence 2:NP_524436.2 Gene:InR / 42549 FlyBaseID:FBgn0283499 Length:2144 Species:Drosophila melanogaster


Alignment Length:1480 Identity:547/1480 - (36%)
Similarity:771/1480 - (52%) Gaps:221/1480 - (14%)


- Green bases have known domain annotations that are detailed below.


Human    35 CPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESL 99
            |..|||||.::..::||||:||||.|.|.|:....|   .:.|||||..:|||::::||.||.||
  Fly   339 CKSMDIRNMVSHFNQLENCTVIEGFLLIDLINDASP---LNRSFPKLTEVTDYIIIYRVTGLHSL 400

Human   100 KDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRIL 164
            ..:||||:||||::||..||||::....|.:|||:.|.:||||.||||||::|||..||||..||
  Fly   401 SKIFPNLSVIRGNKLFDGYALVVYSNFDLMDLGLHKLRSITRGGVRIEKNHKLCYDRTIDWLEIL 465

Human   165 DSVEDNYIVLNKDDNE-ECG-DICPGTAKGKTNCPATVINGQF---------VERCWTHSHCQKV 218
            ...|...:||.::..| ||. ..|||..:.:.....|.|.|:.         ...||....||..
  Fly   466 AENETQLVVLTENGKEKECRLSKCPGEIRIEEGHDTTAIEGELNASCQLHNNRRLCWNSKLCQTK 530

Human   219 CPTICKSHGCTAEGLCCHSECLGNC-SQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVN 282
            ||..|::: |..|..||..:|||.| ...:....|::|||...:..|:::||..||.| |.|||.
  Fly   531 CPEKCRNN-CIDEHTCCSQDCLGGCVIDKNGNESCISCRNVSFNNICMDSCPKGYYQF-DSRCVT 593

Human   283 FSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNLLCTPCL-GPCPKVCHLLEGEK 346
            .:.|..|.....||...|    :.:|.:||..||:||..:.:..:|.||. |.|.|.|    ...
  Fly   594 ANECITLTKFETNSVYSG----IPYNGQCITHCPTGYQKSENKRMCEPCPGGKCDKEC----SSG 650

Human   347 TIDSVTSAQELRGCTVINGS--LIINIR--GGNNLAAELEANLGLIEEISGYLKIRRSYALVSLS 407
            .|||:..|:|..|||:|.|:  |.|:|:  .|.::..||:..|..:.:|...|.:..:|.|.||.
  Fly   651 LIDSLERAREFHGCTIITGTEPLTISIKRESGAHVMDELKYGLAAVHKIQSSLMVHLTYGLKSLK 715

Human   408 FFRKLRLIRGE-TLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEE 471
            ||:.|..|.|: .::...|:.|.|||::|.:||. ....:.|.:|.:|||:|||||:|.|:::..
  Fly   716 FFQSLTEISGDPPMDADKYALYVLDNRDLDELWG-PNQTVFIRKGGVFFHFNPKLCVSTINQLLP 779

Human   472 VSGTKGR-QERNDIALKTNGDQASCENELLKFSYIRTSFDKILLR-------WEPYWPPD----F 524
            :..:|.: .|::|:...:||::.||...:|..:......:..:|.       .||..|.:    |
  Fly   780 MLASKPKFFEKSDVGADSNGNRGSCGTAVLNVTLQSVGANSAMLNVTTKVEIGEPQKPSNATIVF 844

Human   525 RD---LLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPG-WLMRGLKP 585
            :|   .:||:.::...||.|.|: ...|.| .:.|.|        |:..||    | .::..|.|
  Fly   845 KDPRAFIGFVFYHMIDPYGNSTK-SSDDPC-DDRWKV--------SSPEKS----GVMVLSNLIP 895

Human   586 WTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNG 650
            :|.|:.:|:|:...|:   ...|:||:...:|:...||...:.::.:.|.|:|.:.|.....|.|
  Fly   896 YTNYSYYVRTMAISSE---LTNAESDVKNFRTNPGRPSKVTEVVATAISDSKINVTWSYLDKPYG 957

Human   651 NITHYLVFWERQAEDSELFELDYCLKGL----------KLPSRTWSPPFES-----EDSQKHNQS 700
            .:|.|.:..:.....:.....|||.:.|          ..|::..|.|...     |.|:|.:..
  Fly   958 VLTRYFIKAKLINRPTRNNNRDYCTEPLVKAMENDLPATTPTKKISDPLAGDCKCVEGSKKTSSQ 1022

Human   701 EYED---SAGECCSCPKTDSQILKELEESSFRKTFEDYLHNVVFVP--RKTSSGT-----GAED- 754
            ||:|   .||                      ..||:.|.|.:|||  ||:.:|:     |||. 
  Fly  1023 EYDDRKVQAG----------------------MEFENALQNFIFVPNIRKSKNGSSDKSDGAEGA 1065

Human   755 ------------PRPSRKRR------SLGDV-GNV------TVAVPTVAAFPNTSSTSVPTSPE- 793
                        ..|||:||      .|.|| |:|      ::...|.|.|......:.....: 
  Fly  1066 ALDSNAIPNGGATNPSRRRRDVALEPELDDVEGSVLLRHVRSITDDTDAFFEKDDENTYKDEEDL 1130

Human   794 -EHRPFEKVVNKE------SLVISGLRHFTGYRIELQACNQDTPEER----------CSVAAYVS 841
             .::.|.:|..||      ..|...|||||.|.|.:.||.::.|.|:          ||....|.
  Fly  1131 SSNKQFYEVFAKELPPNQTHFVFEKLRHFTRYAIFVVACREEIPSEKLRDTSFKKSLCSDYDTVF 1195

Human   842 ARTMPEAKAD---DIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELH--LCVS 901
            ..|..:..||   |:...:.|.....:.|.:.|..|.:|||.||.|||:|:....:::.  .|:.
  Fly  1196 QTTKRKKFADIVMDLKVDLEHANNTESPVRVRWTPPVDPNGEIVTYEVAYKLQKPDQVEEKKCIP 1260

Human   902 RKHFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKII-----IG- 960
            ...|....|..:: |:.|.||.|:||.|:||.|.:||..:..|    :.|.:.||:.     || 
  Fly  1261 AADFNQTAGYLIK-LNEGLYSFRVRANSIAGYGDFTEVEHIKV----EPPPSYAKVFFWLLGIGL 1320

Human   961 PLIFVFLFSVVIGSIYLFLRKRQPDGPLGPLYASS--NPEYLSASDVFPCSVYVPDEWEVSREKI 1023
            ..:.|.||..|     .:|.||:.  |...|:.::  ||.|.|..       |:||:|||.||.|
  Fly  1321 AFLIVSLFGYV-----CYLHKRKV--PSNDLHMNTEVNPFYASMQ-------YIPDDWEVLRENI 1371

Human  1024 TLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVR 1088
            ..|..||||||||||||..:.......:...|:|||||:|:.|||..||:||||||.|..:||||
  Fly  1372 IQLAPLGQGSFGMVYEGILKSFPPNGVDRECAIKTVNENATDRERTNFLSEASVMKEFDTYHVVR 1436

Human  1089 LLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNP------------GRPPPTLQEMIQMAA 1141
            ||||.|:|||.|||||||..||||||||:.|||..:..            ...|||...:.|||.
  Fly  1437 LLGVCSRGQPALVVMELMKKGDLKSYLRAHRPEERDEAMMTYLNRIGVTGNVQPPTYGRIYQMAI 1501

Human  1142 EIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPE 1206
            |||||||||.|||||||||||||||||.|.||||||||||||||||||||||.|||||||||.||
  Fly  1502 EIADGMAYLAAKKFVHRDLAARNCMVADDLTVKIGDFGMTRDIYETDYYRKGTKGLLPVRWMPPE 1566

Human  1207 SLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRM 1271
            ||:|||::::||::||||||||:.:||.||||||||||||::|:|||.:::|:|||:.:..||:.
  Fly  1567 SLRDGVYSSASDVFSFGVVLWEMATLAAQPYQGLSNEQVLRYVIDGGVMERPENCPDFLHKLMQR 1631

Human  1272 CWQFNPKMRPTFLEIVNLLKDDL-HPSFPEVSFFHSE---ENKAPESEELEMEFEDMENVPLDR- 1331
            ||......||:||:|:..|:... :..|.||||:|||   :::..|.:| ..:.:....||||: 
  Fly  1632 CWHHRSSARPSFLDIIAYLEPQCPNSQFKEVSFYHSEAGLQHREKERKE-RNQLDAFAAVPLDQD 1695

Human  1332 -SSHCQREEA------GGRDGGSSL--------GFKRSYEEHIPYTHMNG 1366
             ....|:|:|      |.....|||        ........|:|::..:|
  Fly  1696 LQDREQQEDATTPLRMGDYQQNSSLDQPPESPIAMVDDQGSHLPFSLPSG 1745

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INSRNP_000199.2 Recep_L_domain 52..164 CDD:460032 60/111 (54%)
Furin-like 179..337 CDD:395614 55/170 (32%)
Recep_L_domain 359..472 CDD:460032 43/117 (37%)
FN3 <582..>658 CDD:442628 21/75 (28%)
FN3 622..>665 CDD:238020 10/42 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..708 9/29 (31%)
Insulin-binding 733..741 3/7 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 746..766 10/43 (23%)
FN3 867..944 CDD:238020 28/78 (36%)
Insulin_TMD 940..987 CDD:465543 13/52 (25%)
PTKc_InsR 1016..1303 CDD:133192 184/299 (62%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1382 2/7 (29%)
PIK3R1-binding 1361..1364 0/2 (0%)
InRNP_524436.2 Recep_L_domain 356..465 CDD:460032 60/111 (54%)
Furin-like 510..645 CDD:395614 46/140 (33%)
Recep_L_domain 663..781 CDD:460032 43/118 (36%)
FN3 791..>964 CDD:442628 47/189 (25%)
FN3 1224..1302 CDD:238020 28/78 (36%)
PTKc_InsR_like 1364..1652 CDD:173625 181/287 (63%)

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