Protein Alignment INSR and Sdr

DIOPT Version :10

• Sequence 1: NP_000199.2
• Gene: INSR / 3643
• HGNCID: 6091
• Length: 1382
• Species: Homo sapiens
• Sequence 2: NP_650408.1
• Gene: Sdr / 41809
• FlyBaseID: FBgn0038279
• Length: 868
• Species: Drosophila melanogaster
• Alignment Length: 935
• Identity: 266/935 - (28%)
• Similarity: 410/935 - (43%)
• Gaps: 212/935 - (22%)

Human    13 PLLVAVAALL--LGAAGHLYPGE----VCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPE 71
            |:.:||..:|  |||:..:....    .|..::| |.:..|.:|:||:.:.||:::..:
  Fly    14 PISIAVPLILLFLGASSPVLASSDDQTACGSLEI-NKIADLRKLQNCTHVVGHVRLAYV------ 71

Human    72 DFRDLS--------FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFN-YALVIFEMVH 127
            |..|:|        ...:..|:|||:::|..||.||:.:||.|.:|||..|.|: |:||::|..:
  Fly    72 DLTDVSGNYSLDSLASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRN 136

Human   128 LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVL--NKDDNEECGDICPGTA 190
            |:||||..|:.|..|.:|:|.|..||::.|:||..::.:....:..|  |:..::     ||
  Fly   137 LRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQ-----CP--- 193

Human   191 KGKTNCPATVINGQFV----ERCWTHSHCQ--------KVCPTICKSHGCTAEGLCCHSECLGNC 243
                .|.:...:.:|:    ||||..:..|        |.||..|..:||.:.|.||...|:..|
  Fly   194 ----LCGSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGC 254

Human   244 -SQPDDPTKCVACRNFYLDGR--CVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYV 305
             ||     .|..|.|:  .||  ||..|... |.....||:.       |.:|:...|..    :
  Fly   255 YSQ-----NCSLCANY--QGRMGCVNQCVAS-YELNKRRCIG-------HRECRELGRIP----L 300

Human   306 IHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLII- 369
            |...:|:.:||.    |...:|....:..|...|:   |:..:.|....:.|:.|..|||||.|
  Fly   301 IRGYQCVKKCPG----NQKEILVAKGIIHCQVECN---GDFHVKSAADLEVLQDCVTINGSLTIE 358

Human   370 --NIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDN 432
              ||:  ..:...||..|..::||:||||:..|..|:||:|.:.|..|||:.|....|:.|.::|
  Fly   359 LTNIK--EKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNN 421

Human   433 QNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN 497
            .:|..:|. ..|.:.|.:|.||||.||:||..:||:::....:.......|::..:||::..|.:
  Fly   422 YHLEHIWP-PNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGD 485

Human   498 ---------ELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGS 553
                     |.|..:.:|...|  .:.||     ....|:|:...|||||.||||.:||:..||.
  Fly   486 AVRSLNPKVEDLNSTAVRIILD--YMDWE-----GMETLIGYSYHYKEAPVQNVTMYDGRHGCGH 543

Human   554 NSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTD 618
            ::| ::|:.|      .:|:.|   ::.||||:||||.||||| |.::......|.|.|.|.||.
  Fly   544 DNW-LMDVVP------NQSRRH---VISGLKPYTQYAYFVKTL-TRTEYHIQIDAYSKIGYFQTL 597

Human   619 ATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSR 683
            ...||..|.....|..||||:|.|.||..|||.|.:|.|..|:.....|..:.:|.
  Fly   598 PDRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYV--------- 653

Human   684 TWSPPFESEDSQKHNQSEYEDSAGECCSC---------PKTDSQILKELEESSFRK---TFEDYL 736
                           ..|.|::....|.|         |:.|       :|..:.|   |:||.|
  Fly   654 ---------------NVELENAKDIDCECAGVLPYYSGPQPD-------DEDYYNKEQITYEDAL 696

Human   737 HNVVFVPRKTSSG--------------TGAEDPRPSRKRRSLGDVGNVTVAVPTVAA--FPN--- 782
            .|:::|.|.....              :..:|..|:|...:.....|.|:|...:||  :.|
  Fly   697 PNLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAINYENYRL 761

Human   783 -----------------TSSTSVPTSPEEHRPF-----EKVVNKESL---VISGLRHF------- 815
                             |...::|.....|...     ||.|.:|.|   .:.|.:||
  Fly   762 NSEKKQRDLQDLDQHKYTIRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHFYCLSQLE 826

Human   816 --TGYRIELQACNQ------DTPEE 832
              |.|||.::||.:      .||.|
  Fly   827 PETHYRITIRACVEGVVNGCSTPAE 851

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INSR	NP_000199.2	Recep_L_domain	52..164	CDD:460032	44/120 (37%)
		Furin-like	179..337	CDD:395614	43/172 (25%)
		Recep_L_domain	359..472	CDD:460032	46/115 (40%)
		FN3	<582..>658	CDD:442628	37/75 (49%)
		FN3	622..>665	CDD:238020	19/42 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	686..708		2/21 (10%)
		Insulin-binding	733..741		4/7 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	746..766		3/33 (9%)
		FN3	867..944	CDD:238020
		Insulin_TMD	940..987	CDD:465543
		PTKc_InsR	1016..1303	CDD:133192
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1360..1382
		PIK3R1-binding	1361..1364
Sdr	NP_650408.1	Recep_L_domain	58..173	CDD:460032	44/120 (37%)
		Furin-like	210..332	CDD:395614	40/147 (27%)
		Recep_L_domain	347..461	CDD:460032	46/116 (40%)
		FN3	491..578	CDD:214495	39/104 (38%)