DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment INSR and Sdr

DIOPT Version :9

Sequence 1:	NP_000199.2	Gene:	INSR / 3643	HGNCID:	6091	Length:	1382	Species:	Homo sapiens
Sequence 2:	NP_001287331.1	Gene:	Sdr / 41809	FlyBaseID:	FBgn0038279	Length:	868	Species:	Drosophila melanogaster

Alignment Length:	935	Identity:	266/935 - (28%)
Similarity:	410/935 - (43%)	Gaps:	212/935 - (22%)

- Green bases have known domain annotations that are detailed below.

Human    13 PLLVAVAALL--LGAAGHLYPGE----VCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPE 71
            |:.:||..:|  |||:..:....    .|..::| |.:..|.:|:||:.:.||:::..:
  Fly    14 PISIAVPLILLFLGASSPVLASSDDQTACGSLEI-NKIADLRKLQNCTHVVGHVRLAYV------ 71

Human    72 DFRDLS--------FPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFN-YALVIFEMVH 127
            |..|:|        ...:..|:|||:::|..||.||:.:||.|.:|||..|.|: |:||::|..:
  Fly    72 DLTDVSGNYSLDSLASNVTEISDYLMVYRCTGLISLQSIFPRLRIIRGQELLFDQYSLVVYENRN 136

Human   128 LKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVL--NKDDNEECGDICPGTA 190
            |:||||..|:.|..|.:|:|.|..||::.|:||..::.:....:..|  |:..::     ||
  Fly   137 LRELGLVELLRIQSGFIRVESNPLLCFVETVDWIYLMGNATRQHFSLKHNRPQSQ-----CP--- 193

Human   191 KGKTNCPATVINGQFV----ERCWTHSHCQ--------KVCPTICKSHGCTAEGLCCHSECLGNC 243
                .|.:...:.:|:    ||||..:..|        |.||..|..:||.:.|.||...|:..|
  Fly   194 ----LCGSLSADFEFIRNSSERCWNVNTTQLRPQPPRLKDCPIACGLNGCDSAGKCCDHNCVTGC 254

Human   244 -SQPDDPTKCVACRNFYLDGR--CVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYV 305
             ||     .|..|.|:  .||  ||..|... |.....||:.       |.:|:...|..    :
  Fly   255 YSQ-----NCSLCANY--QGRMGCVNQCVAS-YELNKRRCIG-------HRECRELGRIP----L 300

Human   306 IHNNKCIPECPSGYTMNSSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLII- 369
            |...:|:.:||.    |...:|....:..|...|:   |:..:.|....:.|:.|..|||||.|
  Fly   301 IRGYQCVKKCPG----NQKEILVAKGIIHCQVECN---GDFHVKSAADLEVLQDCVTINGSLTIE 358

Human   370 --NIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDN 432
              ||:  ..:...||..|..::||:||||:..|..|:||:|.:.|..|||:.|....|:.|.::|
  Fly   359 LTNIK--EKIVDALENALASVKEITGYLKVIHSAQLMSLTFLQNLDAIRGDKLVENKYALYVVNN 421

Human   433 QNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCEN 497
            .:|..:|. ..|.:.|.:|.||||.||:||..:||:::....:.......|::..:||::..|.:
  Fly   422 YHLEHIWP-PNHLVIIQRGTLFFHLNPRLCYEKIHQLQGSLKSGENISVADVSPNSNGERVICGD 485

Human   498 ---------ELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFMLFYKEAPYQNVTEFDGQDACGS 553
                     |.|..:.:|...|  .:.||     ....|:|:...|||||.||||.:||:..||.
  Fly   486 AVRSLNPKVEDLNSTAVRIILD--YMDWE-----GMETLIGYSYHYKEAPVQNVTMYDGRHGCGH 543

Human   554 NSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTD 618
            ::| ::|:.|      .:|:.|   ::.||||:||||.||||| |.::......|.|.|.|.||.
  Fly   544 DNW-LMDVVP------NQSRRH---VISGLKPYTQYAYFVKTL-TRTEYHIQIDAYSKIGYFQTL 597

Human   619 ATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQAEDSELFELDYCLKGLKLPSR 683
            ...||..|.....|..||||:|.|.||..|||.|.:|.|..|:.....|..:.:|.
  Fly   598 PDRPSPVLRIYGSSEISSQILLHWWPPRRPNGVIKNYFVTAEKYNATKEAKDKNYV--------- 653

Human   684 TWSPPFESEDSQKHNQSEYEDSAGECCSC---------PKTDSQILKELEESSFRK---TFEDYL 736
                           ..|.|::....|.|         |:.|       :|..:.|   |:||.|
  Fly   654 ---------------NVELENAKDIDCECAGVLPYYSGPQPD-------DEDYYNKEQITYEDAL 696

Human   737 HNVVFVPRKTSSG--------------TGAEDPRPSRKRRSLGDVGNVTVAVPTVAA--FPN--- 782
            .|:::|.|.....              :..:|..|:|...:.....|.|:|...:||  :.|
  Fly   697 PNLIYVSRNHDYRRKEFEKVINYEHLLSIKKDEEPTRPPTTTPAPTNATLAKERLAAINYENYRL 761

Human   783 -----------------TSSTSVPTSPEEHRPF-----EKVVNKESL---VISGLRHF------- 815
                             |...::|.....|...     ||.|.:|.|   .:.|.:||
  Fly   762 NSEKKQRDLQDLDQHKYTIRHALPKCQNSHASVVQQVEEKCVAEEPLSGYELPGTQHFYCLSQLE 826

Human   816 --TGYRIELQACNQ------DTPEE 832
              |.|||.::||.:      .||.|
  Fly   827 PETHYRITIRACVEGVVNGCSTPAE 851

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
INSR	NP_000199.2	Recep_L_domain	52..164	CDD:279382	44/120 (37%)
		Furin-like	179..337	CDD:279142	43/172 (25%)
		FU	234..281	CDD:238021	16/49 (33%)
		Recep_L_domain	359..472	CDD:279382	46/115 (40%)
		FN3	622..>665	CDD:238020	19/42 (45%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	686..708		2/21 (10%)
		Insulin-binding	733..741		4/7 (57%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	746..766		3/33 (9%)
		FN3	867..944	CDD:238020
		PTKc_InsR	1016..1303	CDD:133192
		Pkinase_Tyr	1023..1290	CDD:285015
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1360..1382
		PIK3R1-binding	1361..1364
Sdr	NP_001287331.1	Recep_L_domain	58..173	CDD:279382	44/120 (37%)
		Furin-like	209..332	CDD:279142	40/148 (27%)
		Recep_L_domain	347..461	CDD:279382	46/116 (40%)
		FN3	491..578	CDD:214495	39/104 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	84	1.000	Domainoid score	I8236
eggNOG	1	0.900	-	-		E2759_KOG4258
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D120934at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820