DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment INSR and CG10702

DIOPT Version :10

Sequence 1:NP_000199.2 Gene:INSR / 3643 HGNCID:6091 Length:1382 Species:Homo sapiens
Sequence 2:NP_724157.1 Gene:CG10702 / 35181 FlyBaseID:FBgn0032752 Length:946 Species:Drosophila melanogaster


Alignment Length:1018 Identity:267/1018 - (26%)
Similarity:434/1018 - (42%) Gaps:224/1018 - (22%)


- Green bases have known domain annotations that are detailed below.


Human    35 CPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSFPKLIMITDYLLLFRVYGLESL 99
            |..:||||....:|.|:||:|:.|::.|.|:...:..:|.:.|:|.|..||::::...|.||.::
  Fly    30 CTSIDIRNECKNMHLLDNCTVVTGYVMITLITIEQRCNFSEYSYPLLTEITEFMIFTDVRGLVNI 94

Human   100 KDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGSVRIEKNNELCYLATIDWSRI- 163
            .::||:||||||.|||.||||.:..|..|::|....|:.|.||.|.|....:||.:..::|..: 
  Fly    95 TEMFPHLTVIRGRRLFLNYALGVTNMHELEQLVFPKLVAIQRGQVYIGSCPKLCSIGRVNWDLLT 159

Human   164 LDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVERCWTHSHCQK-VCPTICKSHG 227
            |...|:|.|::||                  ||...|.:|.....||::.:||: :...:...  
  Fly   160 LTRGENNIIMVNK------------------NCSTPVCSGCSSSHCWSNHYCQRSINENVANP-- 204

Human   228 CTAEGLCCHSECLGNC-SQPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDW-RCVNFSFCQDLH 290
             .|....||.||||.| :....|..|..||....||.||::||...|..::: ||...:.|    
  Fly   205 -KANINACHEECLGGCKNNSSSPADCSVCRGLSDDGVCVKSCPKDKYVMENYQRCYTKAEC---- 264

Human   291 HKCKNSRRQGCHQYVIHNNKCIPECPSGYTMN--SSNLLCTP---CLGPC-PKVCHLLEGEK-TI 348
             ..|       |.|||..::|:..|||||..|  |..:||:|   |:..| |:    ..|:. |:
  Fly   265 -VLK-------HGYVISGSQCVAFCPSGYKTNNRSECVLCSPDEACISFCTPE----WPGKAFTV 317

Human   349 DSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLR 413
            .::..|:.||||.:.||||:|.||...| ..:|..:...:.|:.|::|:.||..|.||.|.|.|.
  Fly   318 YNLADAENLRGCQIFNGSLVITIRNKVN-ETQLYQSFTSMREVRGHVKVYRSSQLRSLQFLRNLE 381

Human   414 LIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGR 478
            .:.|:.||..:|||...||:.|.:||..|: .|...:|.:|.|.|.|||   ..:|.|.......
  Fly   382 RVHGDPLENRHYSFILYDNKELSELWTPSR-QLEFMEGGMFMHRNNKLC---NRRMREFQNAVTH 442

Human   479 QERNDIALKTNGDQASCE------------NELLKFSYIRT-SFDKILLRWEPYWPPDFRDLLGF 530
            ....| :|:||..:..|.            :..:|.|:::: :..||.|...|        ||..
  Fly   443 DRALD-SLQTNDQEVQCSPLKLQLYVQKRTHRSVKLSWLKSQTSQKIELIHRP--------LLPG 498

Human   531 MLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWL--MRGLKPWTQYAIFV 593
            .|:::|      :|.|. ..|...:|....:.|     |...:|...:|  :..|:|.|:|.:.:
  Fly   499 KLYHEE------SELDA-PICTRINWKRRLLFP-----DDLIENGTHYLFDLDDLQPDTRYVVLL 551

Human   594 KTLVTFSDE-RRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLV 657
            :|.  .:|| ...|.|:|::.||||:...|..||..: |..:.|.:.::..    .:.:::..|.
  Fly   552 RTF--GNDEAHEAYEARSELTYVQTELDIPKPPLLEL-VKKTDSSLTVQMA----SHDHVSFLLT 609

Human   658 FWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPK---TDSQI 719
            .:|...:...:.:.:||.:    ||..|      :|........||| ..:||:...   .||:.
  Fly   610 VFELSDDQDYIEQRNYCHQ----PSYVW------QDMDGPRWMAYED-YDDCCAQKAEQFEDSRF 663

Human   720 LKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAAFPNTS 784
            :.::.| .:|.|.:|                          |.....:.:..|::|.:....||:
  Fly   664 IADMRE-QYRCTLDD--------------------------REQCRRLAHTEVSLPQLRLPGNTT 701

Human   785 STSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAK 849
            .            :|         :..|..:..|.::|||||    ...||....:..||.....
  Fly   702 E------------YE---------LKALHRYRLYALQLQACN----PLGCSSHTTLYGRTNYTMG 741

Human   850 ADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALERGC--R 912
            ||.:.......|.|.:...:.::|||:||||:..|.:.:|..        .|:.|.    ||  |
  Fly   742 ADLLTQLYACHIPEMDKYIMRFEEPKKPNGLVTNYVIHFRNN--------FSQTHV----GCVTR 794

Human   913 LRGLSPGNYSVR----------IRATSLAGNGSWTEPTYFYVTDYLDVP------------SNIA 955
            :...|.|...|:          :|..||||:         .:|.|:.:.            |..|
  Fly   795 MDHQSAGYMYVKQINITFTECAVRVHSLAGD---------VMTPYMPISLCSDEDRLQAFHSREA 850

Human   956 KII----------------IGPLIFVFLFSVVIGSIYLFLRKR 982
            |.:                |...:..|||...:..:::..::|
  Fly   851 KDLSPEITDLPATASHGRGISIFLICFLFGCSVSLVWVLYKRR 893

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INSRNP_000199.2 Recep_L_domain 52..164 CDD:460032 42/112 (38%)
Furin-like 179..337 CDD:395614 48/166 (29%)
Recep_L_domain 359..472 CDD:460032 43/112 (38%)
FN3 <582..>658 CDD:442628 20/76 (26%)
FN3 622..>665 CDD:238020 7/42 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..708 4/21 (19%)
Insulin-binding 733..741 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 746..766 1/19 (5%)
FN3 867..944 CDD:238020 22/88 (25%)
Insulin_TMD 940..987 CDD:465543 10/71 (14%)
PTKc_InsR 1016..1303 CDD:133192
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1382
PIK3R1-binding 1361..1364
CG10702NP_724157.1 Recep_L_domain 47..159 CDD:460032 42/111 (38%)
Furin-like 171..297 CDD:395614 46/158 (29%)
Recep_L_domain 328..441 CDD:460032 44/117 (38%)
Blue background indicates that the domain is not in the aligned region.

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