Protein Alignment INSR and Insr

DIOPT Version :10

• Sequence 1: NP_000199.2
• Gene: INSR / 3643
• HGNCID: 6091
• Length: 1382
• Species: Homo sapiens
• Sequence 2: NP_058767.2
• Gene: Insr / 24954
• RGDID: 2917
• Length: 1384
• Species: Rattus norvegicus
• Alignment Length: 1383
• Identity: 1314/1383 - (95%)
• Similarity: 1346/1383 - (97%)
• Gaps: 4/1383 - (0%)

Human     4 GGRRG--AAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMF 66
            |..||  ..|.|||:||||||:|.|||||||||||||||||||||||||||||||||||||||||
  Rat     2 GSGRGCETTAVPLLMAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMF 66

Human    67 KTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL 131
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat    67 KTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL 131

Human   132 GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNC 196
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||
  Rat   132 GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNC 196

Human   197 PATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLD 261
            ||||||||||||||||||||||||||||||||||||||||.|||||||:||||||||||||||||
  Rat   197 PATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLD 261

Human   262 GRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNL 326
            |:|||||||||||||||||||||||||||:||:|||:.|||||||||||||||||||||||||||
  Rat   262 GQCVETCPPPYYHFQDWRCVNFSFCQDLHYKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNL 326

Human   327 LCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEI 391
            :||||||||||||.:||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   327 MCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEI 391

Human   392 SGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFH 456
            ||:||||||||||||||||||.||||||||||||||||||||||||||||:||||||||||||||
  Rat   392 SGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWNKHNLTITQGKLFFH 456

Human   457 YNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWP 521
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
  Rat   457 YNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWP 521

Human   522 PDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQ--NHPGWLMRGLK 584
            |||||||||||||||||||||||||||||||||||||||||||.||||||||  :||||||||||
  Rat   522 PDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLK 586

Human   585 PWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPN 649
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   587 PWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPN 651

Human   650 GNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPK 714
            ||||||||:|||||||||||||||||||||||||||||||||:||||||||||:|||.|||||||
  Rat   652 GNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPK 716

Human   715 TDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAA 779
            |||||||||||||||||||||||||||||||||||.||||.|||||||||.:|||||...||:..
  Rat   717 TDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDTRPSRKRRSLEEVGNVTATTPTLPD 781

Human   780 FPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSART 844
            |||.|||..|||.||||||||||||||||||||||||||||||||||||:|||||||||||||||
  Rat   782 FPNISSTIAPTSHEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPEERCSVAAYVSART 846

Human   845 MPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALER 909
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   847 MPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALER 911

Human   910 GCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGS 974
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
  Rat   912 GCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGS 976

Human   975 IYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYE 1039
            |||||||||||||:|||||||||||||||||||.||||||||||.||||||||||||||||||||
  Rat   977 IYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYE 1041

Human  1040 GNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME 1104
            |||:||||||.||||||||||||||||||||||||||||||||||||||||||||||||||||||
  Rat  1042 GNAKDIIKGEVETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME 1106

Human  1105 LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH 1169
            |||||||||:||||||:||||||||||||||||||.|||||||||||||||||||||||||||||
  Rat  1107 LMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAH 1171

Human  1170 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAE 1234
            ||||||||||||||||||||||||||||||||||:||||||||||.|||||||||||||||||||
  Rat  1172 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAE 1236

Human  1235 QPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFP 1299
            ||||||||||||||||||||||.|||||||:||||||||||||||||||||||||||||||||||
  Rat  1237 QPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFP 1301

Human  1300 EVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHM 1364
            |||||:||||||||||||||||||||||||||||||||||||.|:|||||..||:|:||||||||
  Rat  1302 EVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGCREGGSSLSIKRTYDEHIPYTHM 1366

Human  1365 NGGKKNGRILTLPRSNPS 1382
            ||||||||:|||||||||
  Rat  1367 NGGKKNGRVLTLPRSNPS 1384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INSR	NP_000199.2	Recep_L_domain	52..164	CDD:460032	111/111 (100%)
		Furin-like	179..337	CDD:395614	148/157 (94%)
		Recep_L_domain	359..472	CDD:460032	109/112 (97%)
		FN3	<582..>658	CDD:442628	75/75 (100%)
		FN3	622..>665	CDD:238020	41/42 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	686..708		19/21 (90%)
		Insulin-binding	733..741		7/7 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	746..766		17/19 (89%)
		FN3	867..944	CDD:238020	75/76 (99%)
		Insulin_TMD	940..987	CDD:465543	46/46 (100%)
		PTKc_InsR	1016..1303	CDD:133192	276/286 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1360..1382		20/21 (95%)
		PIK3R1-binding	1361..1364		2/2 (100%)
Insr	NP_058767.2	Recep_L_domain	52..164	CDD:460032	111/111 (100%)
		Furin-like	179..337	CDD:395614	148/157 (94%)
		Recep_L_domain	359..472	CDD:460032	109/112 (97%)
		FN3	<584..>660	CDD:442628	75/75 (100%)
		FN3	624..>667	CDD:238020	41/42 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..710		19/21 (90%)
		Insulin-binding. /evidence=ECO:0000250	735..743		7/7 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	748..784		25/35 (71%)
		FN3	869..946	CDD:238020	75/76 (99%)
		Insulin_TMD	942..989	CDD:465543	46/46 (100%)
		Important for interaction with IRS1, SHC1 and STAT5B	998..1001		2/2 (100%)
		PTKc_InsR	1018..1305	CDD:133192	276/286 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1362..1384		20/21 (95%)
		PIK3R1 binding. /evidence=ECO:0000250	1363..1366		2/2 (100%)