DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment INSR and insrb

DIOPT Version :10

Sequence 1:NP_000199.2 Gene:INSR / 3643 HGNCID:6091 Length:1382 Species:Homo sapiens
Sequence 2:NP_001116701.1 Gene:insrb / 245700 ZFINID:ZDB-GENE-020503-4 Length:1348 Species:Danio rerio


Alignment Length:1378 Identity:908/1378 - (65%)
Similarity:1089/1378 - (79%) Gaps:46/1378 - (3%)


- Green bases have known domain annotations that are detailed below.


Human    14 LLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMFKTRPEDFRDLSF 78
            :::...|.:|...|.|: ||:||..||||..|.|..||||:||||||:|||||||..||||.|||
Zfish     8 VVLVTFAYILCLCGSLH-GEICPSTDIRNIATNLRVLENCTVIEGHLKILLMFKTTQEDFRGLSF 71

Human    79 PKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGLYNLMNITRGS 143
            |||:|:|||||:|||||||||..|||||||||||.||||||||:|||:.:||:||::|.|||||:
Zfish    72 PKLVMVTDYLLIFRVYGLESLGSLFPNLTVIRGSNLFFNYALVMFEMIQMKEIGLHSLTNITRGA 136

Human   144 VRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNCPATVINGQFVER 208
            ||||||..||||:|:|||:|||||||||||.|||| .|||:|||||..|..:|..|.|||.|.||
Zfish   137 VRIEKNPNLCYLSTLDWSKILDSVEDNYIVANKDD-LECGNICPGTIAGTISCKQTTINGNFGER 200

Human   209 CWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLDGRCVETCPPPYY 273
            ||..:|||::||:.|....||:...|||.:|||.||.|.:.|||||||||.....||:.|||.||
Zfish   201 CWNQNHCQRICPSECVHGACTSHKECCHEQCLGGCSVPGNSTKCVACRNFLYGEACVDRCPPGYY 265

Human   274 HFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGY-TMNSSNLLCTPCLGPCPK 337
            .|:.||||:..||||||::||: :...||.|||||..||||||||| |:||::|.|.||.|.|||
Zfish   266 TFKSWRCVSLQFCQDLHNQCKD-KSGDCHAYVIHNGACIPECPSGYTTVNSTSLTCMPCTGRCPK 329

Human   338 VCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYA 402
            ||   .|.:|:||||:||.||||||:||||||.|.|||::|||||::||.:|||:|||.|||:||
Zfish   330 VC---TGVQTVDSVTAAQALRGCTVLNGSLIIKISGGNSIAAELESSLGQLEEITGYLTIRRAYA 391

Human   403 LVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIH 467
            ||||||.|||.|||||||:.|||||:|:|||||||||||:||||||.:|::.|..|.|||.|||.
Zfish   392 LVSLSFLRKLHLIRGETLDGGNYSFHAMDNQNLRQLWDWNKHNLTILKGRMKFIQNGKLCKSEIL 456

Human   468 KMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDFRDLLGFML 532
            :||:.:|||.|.  |||:  ...||:.||:.:|||:.|||..||||:|||.:||.|||||||||:
Zfish   457 RMEQATGTKNRM--NDIS--NEKDQSYCESHILKFTQIRTMSDKILIRWESFWPSDFRDLLGFMV 517

Human   533 FYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLV 597
            .|||||::||||:|||||||||||.:.|::||.|.::.| :..||:|:..||||||||:.||..:
Zfish   518 LYKEAPHRNVTEYDGQDACGSNSWAIADVEPPQRPSEGK-EVEPGYLIMPLKPWTQYAVMVKAQL 581

Human   598 TFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWERQ 662
            ..|::.:..|||::||||:|:||.|||||||.|.||||||||||||||||||||||||:::.::|
Zfish   582 AASEDHQVRGAKTEIIYVRTNATRPSVPLDPHSWSNSSSQIILKWKPPSDPNGNITHYIIYCQKQ 646

Human   663 AEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPKTDSQILKELEESS 727
            :||...::.|||.:|:|:||.| ....:.|:.||.||:|..|..|.||:||||:.|:.||.||:.
Zfish   647 SEDITHYKFDYCQQGMKVPSHT-PTHHDVEEDQKLNQTEVPDQKGHCCACPKTEMQLKKEAEETE 710

Human   728 FRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTV----AVPTVAAFPNTSSTSV 788
            ||||||:||||.||            :|||.|:|||:| |.|.|:    ..||:  .||..:||:
Zfish   711 FRKTFENYLHNEVF------------EPRPHRRRRSVG-VANATLPNFGTTPTI--IPNFPTTSI 760

Human   789 PTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSARTMPEAKADDI 853
            |...:..:...|..:||::|||.|.|||.|:||:.|||..|...|||:..||.|||:||.|||.|
Zfish   761 PEEEKSRKMVFKASSKEAMVISNLLHFTSYQIEIHACNDPTDPGRCSMPTYVKARTLPELKADVI 825

Human   854 VGPVTHEIF--ENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDE-ELHLCVSRKHFALERGCRLRG 915
            ..|||||.|  |.:||::.|:|||.|||:|:||||.|.|..|. |..:||||..:....|.|||.
Zfish   826 AEPVTHEFFPDEPDVVYIRWKEPKTPNGMIILYEVKYLRMSDNYEDQICVSRISYEKNHGYRLRV 890

Human   916 LSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGSI-YLFL 979
            ..|||||||:||||||||||||:|.||||.|    .....||:|...|.:||. |::.|: |..|
Zfish   891 GHPGNYSVRVRATSLAGNGSWTDPAYFYVQD----REMSMKIVIILAICIFLL-VILASVGYFVL 950

Human   980 RKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARD 1044
            :|:|.:||.|||.|||||||:||:|     ||:||||||.|||||::||||||||||||||.|:|
Zfish   951 KKKQTEGPTGPLIASSNPEYISAND-----VYIPDEWEVPREKITVMRELGQGSFGMVYEGIAKD 1010

Human  1045 IIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHG 1109
            |||||.:||||||||||||||||||||||||||||.|:||||||||||||||||||||||||.||
Zfish  1011 IIKGEPDTRVAVKTVNESASLRERIEFLNEASVMKAFSCHHVVRLLGVVSKGQPTLVVMELMTHG 1075

Human  1110 DLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVK 1174
            |||||||||||:||||||.|||||:|||||:||||||||||||||||||||||||||||.|:|||
Zfish  1076 DLKSYLRSLRPDAENNPGSPPPTLKEMIQMSAEIADGMAYLNAKKFVHRDLAARNCMVAEDYTVK 1140

Human  1175 IGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQG 1239
            ||||||||||||||||||||||||||||||||||||||||..||.||||||||||::||||||||
Zfish  1141 IGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTAHSDCWSFGVVLWEISTLAEQPYQG 1205

Human  1240 LSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFF 1304
            |||||||||||||||||:|:|||||:.:||:||||:||||||||.||:.::|:||||:|.|||||
Zfish  1206 LSNEQVLKFVMDGGYLDRPENCPERMHNLMQMCWQYNPKMRPTFHEIIEMIKEDLHPTFQEVSFF 1270

Human  1305 HSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHMNGGKK 1369
            :|||||||||||.:|:||:||::|||.||:.||||:..||.|.|:|.:.:||||:||||||||||
Zfish  1271 YSEENKAPESEEFDMDFENMESIPLDPSSYSQREESHSRDNGPSVGLRGNYEEHVPYTHMNGGKK 1335

Human  1370 NGRILTLPRSNPS 1382
            |||||:||||:||
Zfish  1336 NGRILSLPRSSPS 1348

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INSRNP_000199.2 Recep_L_domain 52..164 CDD:460032 86/111 (77%)
Furin-like 179..337 CDD:395614 90/158 (57%)
Recep_L_domain 359..472 CDD:460032 82/112 (73%)
FN3 <582..>658 CDD:442628 53/75 (71%)
FN3 622..>665 CDD:238020 33/42 (79%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..708 7/21 (33%)
Insulin-binding 733..741 5/7 (71%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 746..766 7/19 (37%)
FN3 867..944 CDD:238020 47/77 (61%)
Insulin_TMD 940..987 CDD:465543 17/47 (36%)
PTKc_InsR 1016..1303 CDD:133192 250/286 (87%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1382 19/21 (90%)
PIK3R1-binding 1361..1364 2/2 (100%)
insrbNP_001116701.1 Recep_L_domain 45..157 CDD:460032 86/111 (77%)
Furin-like 173..329 CDD:395614 90/156 (58%)
Recep_L_domain 348..463 CDD:460032 82/114 (72%)
FN3 <567..>642 CDD:442628 53/74 (72%)
FN3 606..>649 CDD:238020 33/42 (79%)
FN3 838..919 CDD:238020 48/80 (60%)
Insulin_TMD 916..958 CDD:465543 17/46 (37%)
PTKc_InsR 982..1269 CDD:133192 250/286 (87%)

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