DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment INSR and daf-2

DIOPT Version :10

Sequence 1:NP_000199.2 Gene:INSR / 3643 HGNCID:6091 Length:1382 Species:Homo sapiens
Sequence 2:NP_001299916.1 Gene:daf-2 / 175410 WormBaseID:WBGene00000898 Length:1928 Species:Caenorhabditis elegans


Alignment Length:1674 Identity:485/1674 - (28%)
Similarity:725/1674 - (43%) Gaps:428/1674 - (25%)


- Green bases have known domain annotations that are detailed below.


Human    35 CPGMDIRN-------NLTRL----------HELENCSVIEGHLQI--LLMFKTR----------P 70
            |..:||||       ..::|          ..:.||:|:||.|.|  :|..||:          |
 Worm   146 CGPIDIRNRPWDIKPQWSKLGDPNEKDLAGQRMVNCTVVEGSLTISFVLKHKTKAQEEMHRSLQP 210

Human    71 EDFRD--LSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKELGL 133
            ...:|  ::||.|..||..||:|...||..|:.:||||.||.|..|..:|||:|:....| |:||
 Worm   211 RYSQDEFITFPHLREITGTLLVFETEGLVDLRKIFPNLRVIGGRSLIQHYALIIYRNPDL-EIGL 274

Human   134 YNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDN--EECGDICPGTA----KG 192
            ..|..|..|.|||..|.:|||..||||..::.|..::.:|.|..:.  .|.|.:||..|    ||
 Worm   275 DKLSVIRNGGVRIIDNRKLCYTKTIDWKHLITSSINDVVVDNAAEYAVTETGLMCPRGACEEDKG 339

Human   193 KTNCPATVINGQ-----FVERCWTHSHCQKVC------PTICKSHGCTAEGLCCHSECLGNCSQP 246
            ::.|.......|     .|:.||:::.|||.|      ||.....||.|.|..||.:|:|.|.:.
 Worm   340 ESKCHYLEEKNQEQGVERVQSCWSNTTCQKSCAYDRLLPTKEIGPGCDANGDRCHDQCVGGCERV 404

Human   247 DDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKC 311
            :|.|.|.||:|.|..|:|:|.|....|.....|||....|..|:              .:.:||.
 Worm   405 NDATACHACKNVYHKGKCIEKCDAHLYLLLQRRCVTREQCLQLN--------------PVLSNKT 455

Human   312 IP----------ECPSGYTMN-SSNLLCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVING 365
            :|          :||.||.:| ..:..|..|:|.|..||.:   ...||:...||.:|.|.:|:|
 Worm   456 VPIKATAGLCSDKCPDGYQINPDDHRECRKCVGKCEIVCEI---NHVIDTFPKAQAIRLCNIIDG 517

Human   366 SLIINIRG--GNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFY 428
            :|.|.|||  .:.:|:||:.....|..|:|||.:|:|...:||:.||.||.|..::|....|:..
 Worm   518 NLTIEIRGKQDSGMASELKDIFANIHTITGYLLVRQSSPFISLNMFRNLRRIEAKSLFRNLYAIT 582

Human   429 ALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHK--------MEEVSGTKGRQERNDIA 485
            ..:|.||::|:| |..:||:.:|.:....|..||...|.:        ::.:..::|        
 Worm   583 VFENPNLKKLFD-STTDLTLDRGTVSIANNKMLCFKYIKQLMSKLNIPLDPIDQSEG-------- 638

Human   486 LKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWPPDF--RDLLGFMLFYKEAPY--QNVTEFD 546
              |||::|.||:..:..|....:.|.:...|..:...|.  |..||:.||:||.|.  :|:|..:
 Worm   639 --TNGEKAICEDMAINVSITAVNADSVFFSWPSFNITDIDQRKFLGYELFFKEVPRIDENMTIEE 701

Human   547 GQDACGSNSWTVV------------------DIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFV 593
            .:.|| .:||..|                  ||.|..|                ::|.|.||.:|
 Worm   702 DRSAC-VDSWQSVFKQYYETSNGEPTPDIFMDIGPRER----------------IRPNTLYAYYV 749

Human   594 KTLVTFSDERRTYGAK---SDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHY 655
            .|.:...     .|||   |.|.:|:|....|..|...::..:|.: |.:.|:.|..|||::|||
 Worm   750 ATQMVLH-----AGAKNGVSKIGFVRTSYYTPDPPTLALAQVDSDA-IHITWEAPLQPNGDLTHY 808

Human   656 LVFWERQA----EDSELFELDYCL-----------------KGLKLP-SRTWSPPFESEDSQKHN 698
            .:.|....    |::|.|..|...                 |.:.:| |||.:|...:....:..
 Worm   809 TIMWRENEVSPYEEAEKFCTDASTPANRQHTKDPKETIVADKPVDIPSSRTVAPTLLTMMGHEDQ 873

Human   699 QSEYEDSAGECCSCPKTDSQILKELEESSFRK-----------TFEDYLHNVVFVPR-------- 744
            |.....:.| ||||     ..::|..|.:.:|           .||:.|.:.|.:||        
 Worm   874 QKTCAATPG-CCSC-----SAIEESSEQNKKKRPDPMSAIESSAFENKLLDEVLMPRCDIKNDPV 932

Human   745 ----------KTSSGTGAEDPRPS----------------------------------------- 758
                      ...|..|.:|..|.                                         
 Worm   933 GCAMLLLPPEIDDSDVGDDDEEPGGGSEQQQRILRNSEILKRQKRQILGRSLGGIHGIRSIGRKE 997

Human   759 ------------RKRRSLGDVGNVTVAVPTVAAF--------------------PNTSSTSVPTS 791
                        |.|||:.|...|:..:......                    |::|||:...:
 Worm   998 YEQFADMILDTMRVRRSIEDANRVSEELEKAENLGKAPKTLGGKKPLIHISKKKPSSSSTTSTPA 1062

Human   792 PE-------------------------EHRPFEKVVNKESL------VISGLRHFTGYRIELQAC 825
            |.                         |..|....:|..:|      ||..|:|:|.|.|.|.||
 Worm  1063 PTIASMYALTRKPTTVPGTRIRLYEIYEPLPGSWAINVSALALDNSYVIRNLKHYTLYAISLSAC 1127

Human   826 -NQDTPEERCSVAAYVSA--RTMPEAKADDIVGPVTHEIFENN--VVHLMWQEPKEPNGLIVLYE 885
             |...|...||::....|  ||......|.::.......|.||  .|::.|..|.|.||.|..|.
 Worm  1128 QNMTVPGASCSISHRAGALKRTKHITDIDKVLNETIEWRFMNNSQQVNVTWDPPTEVNGGIFGYV 1192

Human   886 VSYRRYGDEELHL--CVSRK--HFALERGCRLRGLSPGNYSVRIRATSLAGNGSWTE-------- 938
            |..:...|..:.:  ||..|  :....:|...:.|:.|.|.|.:.|||:.|.|...|        
 Worm  1193 VKLKSKVDGSIVMTRCVGAKRGYSTRNQGVLFQNLADGRYFVSVTATSVHGAGPEAESSDPIVVM 1257

Human   939 -PTYFYVTDYLDVPSNIAKIIIGP-LIFVFLFSVVIGSIYLFLR-------KRQPDGPLGPLYAS 994
             |.:|.|           :||:|. |:|:.|.|:....||.:::       |...|      :..
 Worm  1258 TPGFFTV-----------EIILGMLLVFLILMSIAGCIIYYYIQVRYGKKVKALSD------FMQ 1305

Human   995 SNPEYLSASDVFPC--SVYVPDEWEVSREKITLLRELGQGSFGMVYEGNARDIIK--GEAETRVA 1055
            .||||        |  :.|..|:||:.::.:.|.::.|:||||.||.|...:::.  |:.....|
 Worm  1306 LNPEY--------CVDNKYNADDWELRQDDVVLGQQCGEGSFGKVYLGTGNNVVSLMGDRFGPCA 1362

Human  1056 VK-TVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLR 1119
            :| .|::.|| .|.:.:|.||::||.|..:.:|:|.||:|..||.:||||:|..|:|:.||||.|
 Worm  1363 IKINVDDPAS-TENLNYLMEANIMKNFKTNFIVKLYGVISTVQPAMVVMEMMDLGNLRDYLRSKR 1426

Human  1120 PEAENNPGR-------PPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGD 1177
            .:...|...       |.....|   .||:|.||||||.:.||.||||||||||:..|.||||||
 Worm  1427 EDEVFNETDCNFFDIIPRDKFHE---WAAQICDGMAYLESLKFCHRDLAARNCMINRDETVKIGD 1488

Human  1178 FGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSN 1242
            |||.||::..|||:..||.::|||||:|||||||.|.:.||:|||||||:|:.:|..|||.||||
 Worm  1489 FGMARDLFYHDYYKPSGKRMMPVRWMSPESLKDGKFDSKSDVWSFGVVLYEMVTLGAQPYIGLSN 1553

Human  1243 EQVLKFV-MDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFPEVSFFHS 1306
            ::||.:: |....:.:|:.|......:|:|||:::|:.|||||::|:||..:..|.|.::||..:
 Worm  1554 DEVLNYIGMARKVIKKPECCENYWYKVMKMCWRYSPRDRPTFLQLVHLLAAEASPEFRDLSFVLT 1618

Human  1307 EENK-------------------------APESEELEM----EFEDMENVPLDR----------S 1332
            :...                         ||:.|.:|:    |..:.:::||.:          :
 Worm  1619 DNQMILDDSEALDLDDIDDTDMNDQVVEVAPDVENVEVQSDSERRNTDSIPLKQFKTIPPINATT 1683

Human  1333 SHCQRE------EAGGRDGGSSLGFKRSYEEHIPYTHMNGGKKNGRILT 1375
            ||....      :|..|:|        |.:|.....:.:||..:..:.|
 Worm  1684 SHSTISIDETPMKAKQREG--------SLDEEYALMNHSGGPSDAEVRT 1724

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
INSRNP_000199.2 Recep_L_domain 52..164 CDD:460032 53/125 (42%)
Furin-like 179..337 CDD:395614 56/185 (30%)
Recep_L_domain 359..472 CDD:460032 40/122 (33%)
FN3 <582..>658 CDD:442628 25/78 (32%)
FN3 622..>665 CDD:238020 13/46 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 686..708 2/21 (10%)
Insulin-binding 733..741 2/7 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 746..766 8/72 (11%)
FN3 867..944 CDD:238020 26/89 (29%)
Insulin_TMD 940..987 CDD:465543 13/54 (24%)
PTKc_InsR 1016..1303 CDD:133192 135/297 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1360..1382 3/16 (19%)
PIK3R1-binding 1361..1364 0/2 (0%)
daf-2NP_001299916.1 Recep_L_domain 180..305 CDD:460032 53/125 (42%)
Furin-like 360..490 CDD:395614 45/143 (31%)
Recep_L_domain 512..627 CDD:460032 40/115 (35%)
FN3 776..>832 CDD:238020 17/56 (30%)
FN3 1169..1255 CDD:238020 26/85 (31%)
PTKc_InsR_like 1321..1604 CDD:173625 133/286 (47%)

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