Protein Alignment INSR and Insr

DIOPT Version :10

• Sequence 1: NP_000199.2
• Gene: INSR / 3643
• HGNCID: 6091
• Length: 1382
• Species: Homo sapiens
• Sequence 2: NP_001316985.1
• Gene: Insr / 16337
• MGIID: 96575
• Length: 1384
• Species: Mus musculus
• Alignment Length: 1383
• Identity: 1317/1383 - (95%)
• Similarity: 1347/1383 - (97%)
• Gaps: 4/1383 - (0%)

Human     4 GGRRG--AAAAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMF 66
            |..||  ..|.||||||||||:|.|||||||||||||||||||||||||||||||||||||||||
Mouse     2 GFGRGCETTAVPLLVAVAALLVGTAGHLYPGEVCPGMDIRNNLTRLHELENCSVIEGHLQILLMF 66

Human    67 KTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL 131
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse    67 KTRPEDFRDLSFPKLIMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYALVIFEMVHLKEL 131

Human   132 GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDICPGTAKGKTNC 196
            |||||||||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||
Mouse   132 GLYNLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNEECGDVCPGTAKGKTNC 196

Human   197 PATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHSECLGNCSQPDDPTKCVACRNFYLD 261
            ||||||||||||||||||||||||||||||||||||||||.|||||||:||||||||||||||||
Mouse   197 PATVINGQFVERCWTHSHCQKVCPTICKSHGCTAEGLCCHKECLGNCSEPDDPTKCVACRNFYLD 261

Human   262 GRCVETCPPPYYHFQDWRCVNFSFCQDLHHKCKNSRRQGCHQYVIHNNKCIPECPSGYTMNSSNL 326
            |:|||||||||||||||||||||||||||.||:|||:.|||||||||||||||||||||||||||
Mouse   262 GQCVETCPPPYYHFQDWRCVNFSFCQDLHFKCRNSRKPGCHQYVIHNNKCIPECPSGYTMNSSNL 326

Human   327 LCTPCLGPCPKVCHLLEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEI 391
            :||||||||||||.:||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   327 MCTPCLGPCPKVCQILEGEKTIDSVTSAQELRGCTVINGSLIINIRGGNNLAAELEANLGLIEEI 391

Human   392 SGYLKIRRSYALVSLSFFRKLRLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFH 456
            ||:||||||||||||||||||.|||||||||||||||||||||||||||||||||||||||||||
Mouse   392 SGFLKIRRSYALVSLSFFRKLHLIRGETLEIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFH 456

Human   457 YNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSYIRTSFDKILLRWEPYWP 521
            |||||||||||||||||||||||||||||||||||||||||||||||:|||||||||||||||||
Mouse   457 YNPKLCLSEIHKMEEVSGTKGRQERNDIALKTNGDQASCENELLKFSFIRTSFDKILLRWEPYWP 521

Human   522 PDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQ--NHPGWLMRGLK 584
            |||||||||||||||||||||||||||||||||||||||||||.||||||||  :||||||||||
Mouse   522 PDFRDLLGFMLFYKEAPYQNVTEFDGQDACGSNSWTVVDIDPPQRSNDPKSQTPSHPGWLMRGLK 586

Human   585 PWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPN 649
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   587 PWTQYAIFVKTLVTFSDERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPN 651

Human   650 GNITHYLVFWERQAEDSELFELDYCLKGLKLPSRTWSPPFESEDSQKHNQSEYEDSAGECCSCPK 714
            ||||||||:|||||||||||||||||||||||||||||||||:||||||||||:|||.|||||||
Mouse   652 GNITHYLVYWERQAEDSELFELDYCLKGLKLPSRTWSPPFESDDSQKHNQSEYDDSASECCSCPK 716

Human   715 TDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGTGAEDPRPSRKRRSLGDVGNVTVAVPTVAA 779
            |||||||||||||||||||||||||||||||||||.||||.|||||||||.:|||||....|:..
Mouse   717 TDSQILKELEESSFRKTFEDYLHNVVFVPRKTSSGNGAEDSRPSRKRRSLEEVGNVTATTLTLPD 781

Human   780 FPNTSSTSVPTSPEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDTPEERCSVAAYVSART 844
            |||.|||.||||.||||||||||||||||||||||||||||||||||||:|:|||||||||||||
Mouse   782 FPNVSSTIVPTSQEEHRPFEKVVNKESLVISGLRHFTGYRIELQACNQDSPDERCSVAAYVSART 846

Human   845 MPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALER 909
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   847 MPEAKADDIVGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRKHFALER 911

Human   910 GCRLRGLSPGNYSVRIRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGS 974
            |||||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   912 GCRLRGLSPGNYSVRVRATSLAGNGSWTEPTYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIGS 976

Human   975 IYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVSREKITLLRELGQGSFGMVYE 1039
            |||||||||||||:|||||||||||||||||||.||||||||||.||||||||||||||||||||
Mouse   977 IYLFLRKRQPDGPMGPLYASSNPEYLSASDVFPSSVYVPDEWEVPREKITLLRELGQGSFGMVYE 1041

Human  1040 GNARDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME 1104
            |||:|||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse  1042 GNAKDIIKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVVSKGQPTLVVME 1106

Human  1105 LMAHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAH 1169
            |||||||||:||||||:||||||||||||||||||.|||||||||||||||||||||||||||||
Mouse  1107 LMAHGDLKSHLRSLRPDAENNPGRPPPTLQEMIQMTAEIADGMAYLNAKKFVHRDLAARNCMVAH 1171

Human  1170 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAE 1234
            ||||||||||||||||||||||||||||||||||:||||||||||.|||||||||||||||||||
Mouse  1172 DFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMSPESLKDGVFTASSDMWSFGVVLWEITSLAE 1236

Human  1235 QPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFP 1299
            ||||||||||||||||||||||.|||||||:||||||||||||||||||||||||||||||||||
Mouse  1237 QPYQGLSNEQVLKFVMDGGYLDPPDNCPERLTDLMRMCWQFNPKMRPTFLEIVNLLKDDLHPSFP 1301

Human  1300 EVSFFHSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGRDGGSSLGFKRSYEEHIPYTHM 1364
            |||||:||||||||||||||||||||||||||||||||||||||:|||||..||:|:||||||||
Mouse  1302 EVSFFYSEENKAPESEELEMEFEDMENVPLDRSSHCQREEAGGREGGSSLSIKRTYDEHIPYTHM 1366

Human  1365 NGGKKNGRILTLPRSNPS 1382
            ||||||||:|||||||||
Mouse  1367 NGGKKNGRVLTLPRSNPS 1384

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
INSR	NP_000199.2	Recep_L_domain	52..164	CDD:460032	111/111 (100%)
		Furin-like	179..337	CDD:395614	148/157 (94%)
		Recep_L_domain	359..472	CDD:460032	110/112 (98%)
		FN3	<582..>658	CDD:442628	75/75 (100%)
		FN3	622..>665	CDD:238020	41/42 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	686..708		19/21 (90%)
		Insulin-binding	733..741		7/7 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	746..766		17/19 (89%)
		FN3	867..944	CDD:238020	75/76 (99%)
		Insulin_TMD	940..987	CDD:465543	46/46 (100%)
		PTKc_InsR	1016..1303	CDD:133192	277/286 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1360..1382		20/21 (95%)
		PIK3R1-binding	1361..1364		2/2 (100%)
Insr	NP_001316985.1	Recep_L_domain	52..164	CDD:460032	111/111 (100%)
		Furin-like	179..337	CDD:395614	148/157 (94%)
		Recep_L_domain	359..472	CDD:460032	110/112 (98%)
		FN3	<584..>660	CDD:442628	75/75 (100%)
		FN3	624..>667	CDD:238020	41/42 (98%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	688..709		18/20 (90%)
		Insulin-binding. /evidence=ECO:0000250	735..743		7/7 (100%)
		FN3	869..946	CDD:238020	75/76 (99%)
		Insulin_TMD	942..989	CDD:465543	46/46 (100%)
		Important for interaction with IRS1, SHC1 and STAT5B. /evidence=ECO:0000250	998..1001		2/2 (100%)
		PTKc_InsR	1018..1305	CDD:133192	277/286 (97%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1361..1384		21/22 (95%)
		PIK3R1 binding. /evidence=ECO:0000250	1363..1366		2/2 (100%)