Protein Alignment Mdr49 and cydD

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_415407.1
• Gene: cydD / 949052
• ECOCYCID: EG11405
• Length: 588
• Species: Escherichia coli
• Alignment Length: 566
• Identity: 149/566 - (26%)
• Similarity: 248/566 - (43%)
• Gaps: 98/566 - (17%)

  Fly   127 VAMFLLITLAIDLANRIALNQIDR----IRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLK 187
            |..|:|....:.|..|:..:....    ||:..|:.:.:...||.......::|:.:.|.:|.:.
E. coli    70 VLTFVLRAWVVWLRERVGYHAGQHIRFAIRRQVLDRLQQAGPAWIQGKPAGSWATLVLEQIDDMH 134

  Fly   188 EGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVV---------------A 237
            :.....:..:...:...::.:|:.|...|...|::|...|.|....::|               |
E. coli   135 DYYARYLPQMALAVSVPLLIVVAIFPSNWAAALILLGTAPLIPLFMALVGMGAADANRRNFLALA 199

  Fly   238 RLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAF-----------SGQEKEKERFGKLLIPAENT 291
            ||.|...::               ..|:.|:..|           |..|..::|..::|
E. coli   200 RLSGHFLDR---------------LRGMETLRIFGRGEAEIESIRSASEDFRQRTMEVL------ 243

  Fly   292 GRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLG 356
             |...|.||:....:.|.|.|   :|:::|.: .|.|.|. ....|...|.....|:|:..:
E. coli   244 -RLAFLSSGILEFFTSLSIAL---VAVYFGFS-YLGELDF-GHYDTGVTLAAGFLALILAPE--- 299

  Fly   357 FASP--------HVEAIAVATAAGQTLFNIIDRP-----------SQVDPMDEKGNRPENTAGHI 402
            |..|        |.:|.||  .|..:|...::.|           :..||:.            |
E. coli   300 FFQPLRDLGTFYHAKAQAV--GAADSLKTFMETPLAHPQRGEAELASTDPVT------------I 350

  Fly   403 RFEGIRFRYPARPDVEILKGLTVDVLP-GQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGR 466
            ..|.:   :...|:.:.|.|.....|| ||....||.||.|||:|:..:..|...: ||::::|.
E. coli   351 EAEEL---FITSPEGKTLAGPLNFTLPAGQRAVLVGRSGSGKSSLLNALSGFLSYQ-GSLRINGI 411

  Fly   467 DLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYD 531
            :||.|:....|..:..|||.|.|.|.|:.:|:...||.|::.:::.|...|...:|:..||:|.|
E. coli   412 ELRDLSPESWRKHLSWVGQNPQLPAATLRDNVLLARPDASEQELQAALDNAWVSEFLPLLPQGVD 476

  Fly   532 TQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVA 596
            |.||::.|::|.||.||:|:||||:....:|||||..::||..||:||..||..||...|||:|.
E. coli   477 TPVGDQAARLSVGQAQRVAVARALLNPCSLLLLDEPAASLDAHSEQRVMEALNAASLRQTTLMVT 541

  Fly   597 HRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRK 642
            |:|..:.:.|.|..::||.:.|||.:.||....|.:..|::..|.:
E. coli   542 HQLEDLADWDVIWVMQDGRIIEQGRYAELSVAGGPFATLLAHRQEE 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	149/566 (26%)
		MdlB	720..1299	CDD:440747
cydD	NP_415407.1	PRK11174	1..588	CDD:236870	149/566 (26%)