Protein Alignment Mdr49 and mdlA

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_414982.1
• Gene: mdlA / 945092
• ECOCYCID: G6248
• Length: 590
• Species: Escherichia coli
• Alignment Length: 681
• Identity: 179/681 - (26%)
• Similarity: 297/681 - (43%)
• Gaps: 169/681 - (24%)

  Fly    35 FRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQL 99
            ||...|  |:|..|:|||..|....:|              .:.||:
E. coli    11 FRREWR--RYLGAVALLVIIAMLQLVP--------------PKVVGI------------------ 41

  Fly   100 TNASKEENNQAIIDDATA--FGIGSLVGSVAMFLLITLAIDLANRI-------ALNQID-RIRKL 154
                       ::|..|.  |..|.::..:|..:||.:.:.|...:       |..|:. .:|:.
E. coli    42 -----------VVDGVTEQHFTTGQILMWIATMVLIAVVVYLLRYVWRVLLFGASYQLAVELRED 95

  Fly   155 FLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVV-FLIMTFVIGIVSAFVYGWKL 218
            :...:.||...:|......:..::.|.|:|::....||.::.:| .|:|...:.|:.:....|:|
E. coli    96 YYRQLSRQHPEFYLRHRTGDLMARATNDVDRVVFAAGEGVLTLVDSLVMGCAVLIMMSTQISWQL 160

  Fly   219 TLVVLSCVPFIIAATSVVARLQGSLAEKELK----SYSDAANVVEEVFSGIRTVFAFSGQEKEKE 279
            ||..|..:|.:    :::.:..|....:..|    ::|...:..:|..:.||.:.||..::::..
E. coli   161 TLFSLLPMPVM----AIMIKRNGDALHERFKLAQAAFSSLNDRTQESLTSIRMIKAFGLEDRQSA 221

  Fly   280 RFGKLLIPAENTGRKK------------GLY--SGMGNAL-----SWLII------------YLC 313
            .|.   ..||:||:|.            .:|  .||.|.|     ||:::            .:.
E. coli   222 LFA---ADAEDTGKKNMRVARIDARFDPTIYIAIGMANLLAIGGGSWMVVQGSLTLGQLTSFMMY 283

  Fly   314 MALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNI 378
            :.|.||                                           ..:|:|     .:|||
E. coli   284 LGLMIW-------------------------------------------PMLALA-----WMFNI 300

  Fly   379 IDRPSQV----------DPMDEKGNRP-ENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQT 432
            ::|.|..          .|:...|:.| ....|.:.....:|.|| :.|...|:.:...:.|||.
E. coli   301 VERGSAAYSRIRAMLAEAPVVNDGSEPVPEGRGELDVNIHQFTYP-QTDHPALENVNFALKPGQM 364

  Fly   433 VAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGEN 497
            :...|.:|.|||||:.|:||.:|...|.::.....|..|.:...||::.||.|.|.||:.|:..|
E. coli   365 LGICGPTGSGKSTLLSLIQRHFDVSEGDIRFHDIPLTKLQLDSWRSRLAVVSQTPFLFSDTVANN 429

  Fly   498 IRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVL 562
            |..|.|:|||.:||..||.|:.||.|.|||:||||:|||:|..:||||||||:|||||:...::|
E. coli   430 IALGCPNATQQEIEHVARLASVHDDILRLPQGYDTEVGERGVMLSGGQKQRISIARALLVNAEIL 494

  Fly   563 LLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELME 627
            :||:|.||:|..:|.::...|....||.|.::.|||||.:|.|.:|:.::.|.:|::|.|:.|.:
E. coli   495 ILDDALSAVDGRTEHQILHNLRQWGQGRTVIISAHRLSALTEASEIIVMQHGHIAQRGNHDVLAQ 559

  Fly   628 RRGLYCELVSITQ-----------RKEATEA 647
            :.|.|.::....|           |:||.:|
E. coli   560 QSGWYRDMYRYQQLEAALDDAPENREEAVDA 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	172/666 (26%)
		MdlB	720..1299	CDD:440747
mdlA	NP_414982.1	PRK10789	22..590	CDD:182732	173/666 (26%)