DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr49 and ABCB11

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:XP_011510379.1 Gene:ABCB11 / 8647 HGNCID:42 Length:1355 Species:Homo sapiens


Alignment Length:1344 Identity:527/1344 - (39%)
Similarity:783/1344 - (58%) Gaps:114/1344 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGE 69
            ::|||...     |:|..|    :..:|.|||:|:..:.:|:.|..|.|.......|..::|:|.
Human    64 KKSRLQDE-----KKGDGV----RVGFFQLFRFSSSTDIWLMFVGSLCAFLHGIAQPGVLLIFGT 119

  Fly    70 FTSLLVDRTVGVGTSSPAFALPMFGGGQQL--------------TNASKEENNQAIIDDATAFGI 120
            .|.:.:|..|.:               |:|              ||:|..:|    :.:.|..|:
Human   120 MTDVFIDYDVEL---------------QELQIPGKACVNNTIVWTNSSLNQN----MTNGTRCGL 165

  Fly   121 ----------GSLVGSVAMFLLITLAIDLANRI--ALNQIDRIRKLFLEAMLRQDIAWYDTSSGS 173
                      .|....:|:.:|||..|.:...:  |..||.::||.:...::|.:|.|:|.:|..
Human   166 LNIESEMIKFASYYAGIAVAVLITGYIQICFWVIAAARQIQKMRKFYFRRIMRMEIGWFDCNSVG 230

  Fly   174 NFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVAR 238
            ...::.::|::|:.:.|.:::.:.:..:.:.:.|.:..|..|||||||::|..|.|....:.:..
Human   231 ELNTRFSDDINKINDAIADQMALFIQRMTSTICGFLLGFFRGWKLTLVIISVSPLIGIGAATIGL 295

  Fly   239 LQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGN 303
            ......:.|||:|:.|..|.:||.|.:|||.||.|:::|.||:.|.|:.|:..|.:||:..|...
Human   296 SVSKFTDYELKAYAKAGVVADEVISSMRTVAAFGGEKREVERYEKNLVFAQRWGIRKGIVMGFFT 360

  Fly   304 ALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVA 368
            ...|.:|:||.|||.|||.||:|||.:     |||..||.:..:||:||.|||.|||.:||.|..
Human   361 GFVWCLIFLCYALAFWYGSTLVLDEGE-----YTPGTLVQIFLSVIVGALNLGNASPCLEAFATG 420

  Fly   369 TAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTV 433
            .||..::|..|||...:|.|.|.|.:.:...|.|.|..:.|.||:||:|:||..|.:.:.||:..
Human   421 RAAATSIFETIDRKPIIDCMSEDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNDLNMVIKPGEMT 485

  Fly   434 AFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENI 498
            |.||.||.||||.:||:||||||..|.|.:||.|:|:||:.|||.|||:|.||||||:|||.|||
Human   486 ALVGPSGAGKSTALQLIQRFYDPCEGMVTVDGHDIRSLNIQWLRDQIGIVEQEPVLFSTTIAENI 550

  Fly   499 RYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLL 563
            ||||..||..||.:||:.||.::||..||:.:||.|||.|.|:|||||||:||||||:|.|::||
Human   551 RYGREDATMEDIVQAAKEANAYNFIMDLPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILL 615

  Fly   564 LDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMER 628
            ||.||||||..||..||..|.....|.|.:.|||||||:..||.|:..:.|...|:||||||:||
Human   616 LDMATSALDNESEAMVQEVLSKIQHGHTIISVAHRLSTVRAADTIIGFEHGTAVERGTHEELLER 680

  Fly   629 RGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSG 693
            :|:|..||::..                 |.:|.|::|:..|..||   |......:.||.:|| 
Human   681 KGVYFTLVTLQS-----------------QGNQALNEEDIKDATED---DMLARTFSRGSYQDS- 724

  Fly   694 FRASTRRKRRSQ------------------RRKKKKDKEV-----VSKVSFTQLMKLNSPEWRFI 735
            .|||.|::.:||                  ..:.:|||::     |......:::|.::|||.::
Human   725 LRASIRQRSKSQLSYLVHEPPLAVVDHKSTYEEDRKDKDIPVQEEVEPAPVRRILKFSAPEWPYM 789

  Fly   736 VVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMF 800
            :||.:.:.::|...||:...|....|..|..|.:..|:::..:.::||.:|.::.....||.|.|
Human   790 LVGSVGAAVNGTVTPLYAFLFSQILGTFSIPDKEEQRSQINGVCLLFVAMGCVSLFTQFLQGYAF 854

  Fly   801 TTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVAT 865
            ..:|..:|.||||..|..::|||||:|||.|||.|||.:|||:|.|.||||.|:::|.::.:...
Human   855 AKSGELLTKRLRKFGFRAMLGQDIAWFDDLRNSPGALTTRLATDASQVQGAAGSQIGMIVNSFTN 919

  Fly   866 LVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTV 930
            :.|.|::.|.|||:.:|:.|...|.:.||...:.|.:...|.:.|.::|...|:..||::|||||
Human   920 VTVAMIIAFSFSWKLSLVILCFFPFLALSGATQTRMLTGFASRDKQALEMVGQITNEALSNIRTV 984

  Fly   931 NGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYE 995
            .|:..||:.::....::::......:|....|..||..|...|:|...|..|||.|::.|.:::.
Human   985 AGIGKERRFIEALETELEKPFKTAIQKANIYGFCFAFAQCIMFIANSASYRYGGYLISNEGLHFS 1049

  Fly   996 DIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTV----EKSE 1056
            .:.:|..|::..:..||:|.:|.|:...|.:||.|...|..|     .||.|.|||.    :..:
Human  1050 YVFRVISAVVLSATALGRAFSYTPSYAKAKISAARFFQLLDR-----QPPISVYNTAGEKWDNFQ 1109

  Fly  1057 GDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLS 1121
            |.|.:.:..|.||:|..:.:|.||:::|....|:|.||.||.||||.:|||.|:|||..|.|.:.
Human  1110 GKIDFVDCKFTYPSRPDSQVLNGLSVSISPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGKVMID 1174

  Fly  1122 GVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISAL 1186
            |..|.:..:..|||.:|:||||||||..:|.:||.||:|.: ::.|:.:|.|||::.:|:|:.:|
Human  1175 GHDSKKVNVQFLRSNIGIVSQEPVLFACSIMDNIKYGDNTK-EIPMERVIAAAKQAQLHDFVMSL 1238

  Fly  1187 PQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRT 1250
            |:.|:|.:| :.||||.|:|||||||||:||:||||:|||||||||.||||.||.|||:||.|||
Human  1239 PEKYETNVGSQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQVALDKAREGRT 1303

  Fly  1251 CLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANL 1294
            |:.|||||:|::|||:|.|:.:|||:|.|||:||||....|..|
Human  1304 CIVIAHRLSTIQNADIIAVMAQGVVIEKGTHEELMAQKGAYYKL 1347

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 258/631 (41%)
ABC_membrane 116..352 CDD:279056 80/247 (32%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 134/233 (58%)
MdlB 735..1299 CDD:224055 236/565 (42%)
ABC_membrane 739..998 CDD:279056 86/258 (33%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 128/237 (54%)
ABCB11XP_011510379.1 PTZ00265 52..1348 CDD:240339 527/1344 (39%)
ABC_membrane 101..405 CDD:279056 95/327 (29%)
ABC_MTABC3_MDL1_MDL2 454..691 CDD:213216 136/236 (58%)
ABC_membrane 794..1043 CDD:279056 85/248 (34%)
ABC_MTABC3_MDL1_MDL2 1112..1351 CDD:213216 128/237 (54%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 207 1.000 Domainoid score I2881
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S2081
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
98.810

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