Protein Alignment Mdr49 and MDL1

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_013289.1
• Gene: MDL1 / 850885
• SGDID: S000004178
• Length: 695
• Species: Saccharomyces cerevisiae
• Alignment Length: 666
• Identity: 199/666 - (29%)
• Similarity: 317/666 - (47%)
• Gaps: 59/666 - (8%)

  Fly   656 PLQKSQNLSDEETDDDEEDEEEDEEPELQTS-GSSRDSGFRASTRRKRRSQRRKKKKDKEVVSKV 719
            |.:|...|.......|....::..:|.|:.| .:|:.|||:
Yeast    47 PHRKHFLLRSIRLQSDIAQGKKSTKPTLKLSNANSKSSGFK------------------------ 87

  Fly   720 SFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGD-DDVVRAEVLKI----- 778
            ...:|..|:.||.::|.:..:..::..:.........|....:.|:.| :|...::..|:
Yeast    88 DIKRLFVLSKPESKYIGLALLLILISSSVSMAVPSVIGKLLDLASESDGEDEEGSKSNKLYGFTK 152

  Fly   779 SMIFVGIG---LMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSR 840
            ...|..:|   ::..:.|..:..:....|.::..|||.|.....:.||..:.|  .|.||.|.||
Yeast   153 KQFFTALGAVFIIGAVANASRIIILKVTGERLVARLRTRTMKAALDQDATFLD--TNRVGDLISR 215

  Fly   841 LASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKS 905
            |:||.|.|..:....|....:|:....||..:....||:.|.:.::..|.:.....:.||.|...
Yeast   216 LSSDASIVAKSVTQNVSDGTRAIIQGFVGFGMMSFLSWKLTCVMMILAPPLGAMALIYGRKIRNL 280

  Fly   906 AQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFA---- 966
            :::.:.|:...::||.|.:...||:.....|:..:.:|.:::..|.....::....||.|.
Yeast   281 SRQLQTSVGGLTKVAEEQLNATRTIQAYGGEKNEVRRYAKEVRNVFHIGLKEAVTSGLFFGSTGL 345

  Fly   967 LGQAA--PFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAG 1029
            :|..|  ..|..|.||...|.:...|..::     :..|:..||.:.|.:..|:..:..| .:|.
Yeast   346 VGNTAMLSLLLVGTSMIQSGSMTVGELSSF-----MMYAVYTGSSLFGLSSFYSELMKGA-GAAA 404

  Fly  1030 RLMDLFKRTS-TQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALV 1093
            |:.:|..|.. .:|...:.|.:..:|   .||::||.|.||||....|.:.||:|||....|..|
Yeast   405 RVFELNDRKPLIRPTIGKDPVSLAQK---PIVFKNVSFTYPTRPKHQIFKDLNITIKPGEHVCAV 466

  Fly  1094 GPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYG 1158
            |||||||||...|||||||..|||:.........|.|...|..:|.|.|||:||:.||.:||.|
Yeast   467 GPSGSGKSTIASLLLRYYDVNSGSIEFGDEDIRNFNLRKYRRLIGYVQQEPLLFNGTILDNILY- 530

  Fly  1159 NNFRDDVSMQE--IIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKI 1220
             ....:::.|:  |..|..|:|...|::..|.|..|.:| :.:|||||||||||:|||.:.:|.:
Yeast   531 -CIPPEIAEQDDRIRRAIGKANCTKFLANFPDGLQTMVGARGAQLSGGQKQRIALARAFLLDPAV 594

  Fly  1221 LILDEATSALDLESEKVVQQALD-EARSGRTCLTIAHRLTTVRNADLICVL-KRGVVVEHGTHDE 1283
            |||||||||||.:||::|.:.|. ....|.|.::|||||:|::::..:.|| |.|.|||.|:..:
Yeast   595 LILDEATSALDSQSEEIVAKNLQRRVERGFTTISIAHRLSTIKHSTRVIVLGKHGSVVETGSFRD 659

  Fly  1284 LMALNKIYANLYLMQQ 1299
            |:|:.....|..|.:|
Yeast   660 LIAIPNSELNALLAEQ 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055
		ABC_membrane	116..352	CDD:279056
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216
		MdlB	735..1299	CDD:224055	183/584 (31%)
		ABC_membrane	739..998	CDD:279056	58/273 (21%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	111/243 (46%)
MDL1	NP_013289.1	MdlB	116..676	CDD:224055	183/573 (32%)
		ABC_membrane	116..386	CDD:279056	61/276 (22%)
		ABC_MTABC3_MDL1_MDL2	432..676	CDD:213216	112/246 (46%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I2757
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.810