Protein Alignment Mdr49 and MDL1

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_013289.1
• Gene: MDL1 / 850885
• SGDID: S000004178
• Length: 695
• Species: Saccharomyces cerevisiae
• Alignment Length: 666
• Identity: 199/666 - (29%)
• Similarity: 317/666 - (47%)
• Gaps: 59/666 - (8%)

  Fly   656 PLQKSQNLSDEETDDDEEDEEEDEEPELQTS-GSSRDSGFRASTRRKRRSQRRKKKKDKEVVSKV 719
            |.:|...|.......|....::..:|.|:.| .:|:.|||:
Yeast    47 PHRKHFLLRSIRLQSDIAQGKKSTKPTLKLSNANSKSSGFK------------------------ 87

  Fly   720 SFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGD-DDVVRAEVLKI----- 778
            ...:|..|:.||.::|.:..:..::..:.........|....:.|:.| :|...::..|:
Yeast    88 DIKRLFVLSKPESKYIGLALLLILISSSVSMAVPSVIGKLLDLASESDGEDEEGSKSNKLYGFTK 152

  Fly   779 SMIFVGIG---LMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSR 840
            ...|..:|   ::..:.|..:..:....|.::..|||.|.....:.||..:.|  .|.||.|.||
Yeast   153 KQFFTALGAVFIIGAVANASRIIILKVTGERLVARLRTRTMKAALDQDATFLD--TNRVGDLISR 215

  Fly   841 LASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKS 905
            |:||.|.|..:....|....:|:....||..:....||:.|.:.::..|.:.....:.||.|...
Yeast   216 LSSDASIVAKSVTQNVSDGTRAIIQGFVGFGMMSFLSWKLTCVMMILAPPLGAMALIYGRKIRNL 280

  Fly   906 AQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFA---- 966
            :::.:.|:...::||.|.:...||:.....|:..:.:|.:::..|.....::....||.|.
Yeast   281 SRQLQTSVGGLTKVAEEQLNATRTIQAYGGEKNEVRRYAKEVRNVFHIGLKEAVTSGLFFGSTGL 345

  Fly   967 LGQAA--PFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAG 1029
            :|..|  ..|..|.||...|.:...|..::     :..|:..||.:.|.:..|:..:..| .:|.
Yeast   346 VGNTAMLSLLLVGTSMIQSGSMTVGELSSF-----MMYAVYTGSSLFGLSSFYSELMKGA-GAAA 404

  Fly  1030 RLMDLFKRTS-TQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALV 1093
            |:.:|..|.. .:|...:.|.:..:|   .||::||.|.||||....|.:.||:|||....|..|
Yeast   405 RVFELNDRKPLIRPTIGKDPVSLAQK---PIVFKNVSFTYPTRPKHQIFKDLNITIKPGEHVCAV 466

  Fly  1094 GPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYG 1158
            |||||||||...|||||||..|||:.........|.|...|..:|.|.|||:||:.||.:||.|
Yeast   467 GPSGSGKSTIASLLLRYYDVNSGSIEFGDEDIRNFNLRKYRRLIGYVQQEPLLFNGTILDNILY- 530

  Fly  1159 NNFRDDVSMQE--IIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKI 1220
             ....:::.|:  |..|..|:|...|::..|.|..|.:| :.:|||||||||||:|||.:.:|.:
Yeast   531 -CIPPEIAEQDDRIRRAIGKANCTKFLANFPDGLQTMVGARGAQLSGGQKQRIALARAFLLDPAV 594

  Fly  1221 LILDEATSALDLESEKVVQQALD-EARSGRTCLTIAHRLTTVRNADLICVL-KRGVVVEHGTHDE 1283
            |||||||||||.:||::|.:.|. ....|.|.::|||||:|::::..:.|| |.|.|||.|:..:
Yeast   595 LILDEATSALDSQSEEIVAKNLQRRVERGFTTISIAHRLSTIKHSTRVIVLGKHGSVVETGSFRD 659

  Fly  1284 LMALNKIYANLYLMQQ 1299
            |:|:.....|..|.:|
Yeast   660 LIAIPNSELNALLAEQ 675

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747
		MdlB	720..1299	CDD:440747	187/599 (31%)
MDL1	NP_013289.1	MdlB	82..679	CDD:440747	191/631 (30%)