DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB13

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_174115.1	Gene:	ABCB13 / 839687	AraportID:	AT1G27940	Length:	1245	Species:	Arabidopsis thaliana

Alignment Length:	1330	Identity:	480/1330 - (36%)
Similarity:	724/1330 - (54%)	Gaps:	137/1330 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYG 68
            |||.:       .:|:.||       |...||..:.:.:.||:::..|.|....|.:|.|.:.:|
plant    19 KEEKK-------NIKKESV-------SLMGLFSAADKLDYFLMLLGGLGACIHGATLPLFFVFFG 69

  Fly    69 EFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLI 133
            :    ::|....:.|...|                                |.|.|...|::|:.
plant    70 K----MLDSLGNLSTDPKA--------------------------------ISSRVSQNALYLVY 98

  Fly   134 TLAIDLANRIAL------------NQIDRIRKLFLEAMLRQDIAWYDTSS-GSNFASKMTEDLDK 185
               :.|.|.::.            .|..|:|..:|:::|.:||.::||.: .||....::.|...
plant    99 ---LGLVNFVSAWIGVSCWMQTGERQTARLRINYLKSILAKDITFFDTEARDSNLIFHISSDAIL 160

  Fly   186 LKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKS 250
            :::.||:|...|:..:..|:.|.|..|:..|:|||:.|..||.|..|....|.:..:::||...:
plant   161 VQDAIGDKTDHVLRYLSQFIAGFVIGFLSVWQLTLLTLGVVPLIAIAGGGYAIVMSTISEKSETA 225

  Fly   251 YSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMA 315
            |:||..|.|||.|.:|||:||.|:||..:.:...|..|...|::.||..|:|..|::.:::...|
plant   226 YADAGKVAEEVMSQVRTVYAFVGEEKAVKSYSNSLKKALKLGKRSGLAKGLGVGLTYSLLFCAWA 290

  Fly   316 LAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNII- 379
            |.:||...|:...:....:.:|      .:..||.....||.|:|.:.|||....|...:|.:|
plant   291 LLLWYASLLVRHGKTNGAKAFT------TILNVIFSGFALGQAAPSLSAIAKGRVAAANIFRMIG 349

  Fly   380 DRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKS 444
            :..|:.....::|...:|.||.|.|:.:.|.||:||:: :.:.|:..:..|:|.||||.||.|||
plant   350 NNNSESSQRLDEGTTLQNVAGRIEFQKVSFAYPSRPNM-VFENLSFTIRSGKTFAFVGPSGSGKS 413

  Fly   445 TLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQAD 509
            |:|.::||||:|.:|.:.|||.|:::|.:.|.|.|:|:|.|||.||||||..||..|:.:|....
plant   414 TIISMVQRFYEPNSGEILLDGNDIKSLKLKWFREQLGLVSQEPALFATTIASNILLGKENANMDQ 478

  Fly   510 IEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPT 574
            |.:||:|||...||..||.||:|||||.|.|:|||||||||||||::|.|::|||||||||||..
plant   479 IIEAAKAANADSFIKSLPNGYNTQVGEGGTQLSGGQKQRIAIARAVLRNPKILLLDEATSALDAE 543

  Fly   575 SEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSIT 639
            |||.||.||:...:..||:|||||||||.|.||||.|:||.|.|.|:|.|||.|.|.|..||:.
plant   544 SEKIVQQALDNVMEKRTTIVVAHRLSTIRNVDKIVVLRDGQVRETGSHSELMLRGGDYATLVNC- 607

  Fly   640 QRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRS 704
                                      :||:..|.......|.....:|||  |..|.|:.|:..|
plant   608 --------------------------QETEPQENSRSIMSETCKSQAGSS--SSRRVSSSRRTSS 644

  Fly   705 QRRKKKKDKEVVSKVSFT------QLMKLNSPEWRFIVVGGIASVMHGATFPLWGL--------F 755
            .|..::|.|...||..|:      :|:|||||||.:.::|.|.:|:.||..||:.:        |
plant   645 FRVDQEKTKNDDSKKDFSSSSMIWELIKLNSPEWPYALLGSIGAVLAGAQTPLFSMGIAYVLTAF 709

  Fly   756 FGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTII 820
            :..|        .:|::.:|.|:::||.|.|::.....:||.|.:|..|.::|:|:|...|..|:
plant   710 YSPF--------PNVIKRDVEKVAIIFAGAGIVTAPIYLLQHYFYTLMGERLTSRVRLSLFSAIL 766

  Fly   821 GQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTL 885
            ..:|.:||.:.|:.|:|.|.||:|.:.|:.|...|:.|::|.::..|..:.:.|.:||:...:..
plant   767 SNEIGWFDLDENNTGSLTSILAADATLVRSALADRLSTIVQNLSLTVTALALAFFYSWRVAAVVT 831

  Fly   886 VTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRV 950
            ...||:..:...|..|:.........:...|:.||.|||.|||||.....|:|:.:|:..::.:.
plant   832 ACFPLLIAASLTEQLFLKGFGGDYTRAYSRATSVAREAIANIRTVAAYGAEKQISEQFTCELSKP 896

  Fly   951 DIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQAL 1015
            ......:....|..:.|.|...|.:|.:.::|..:|:..:..|:.|.||....||..::.:.:.|
plant   897 TKNAFVRGHISGFGYGLSQFLAFCSYALGLWYVSVLINHKETNFGDSIKSFMVLIVTAFSVSETL 961

  Fly  1016 AYAPNV---NDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPIL 1077
            |..|::   ..|:.|..|:  |.:.|...|:.|.|  ..|.:.:|||.:.||.|.||||....|.
plant   962 ALTPDIVKGTQALGSVFRV--LHRETKISPDQPNS--RMVSQVKGDIEFRNVSFVYPTRPEIDIF 1022

  Fly  1078 QGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQ 1142
            :.|||.:....::|:||||||||||.:.|::|:|||.:|::.:.|.......|.:||.||.||.|
plant  1023 KNLNLRVSAGKSLAVVGPSGSGKSTVIGLIMRFYDPSNGNLCIDGQDIKTLNLRSLRKKLALVQQ 1087

  Fly  1143 EPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQ 1206
            ||.||..||.|||.|||   ::.|..||:||||.:|.|.||..:.:||.|..| |..||||||||
plant  1088 EPALFSTTIYENIKYGN---ENASEAEIMEAAKAANAHEFIIKMEEGYKTHAGDKGVQLSGGQKQ 1149

  Fly  1207 RIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLK 1271
            |:|||||::::|.:|:|||||||||..|||:||:|||:...|||.:.:||||:|:|.||.:.||.
plant  1150 RVAIARAVLKDPSVLLLDEATSALDTSSEKLVQEALDKLMKGRTTVLVAHRLSTIRKADTVAVLH 1214

  Fly  1272 RGVVVEHGTHDELMAL-NKIYANLYLMQQV 1300
            :|.|||.|:|.||::: |..|..|..:|:|
plant  1215 KGRVVEKGSHRELVSIPNGFYKQLTSLQEV 1244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	232/619 (37%)
		ABC_membrane	116..352	CDD:279056	71/248 (29%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	131/233 (56%)
		MdlB	735..1299	CDD:224055	213/576 (37%)
		ABC_membrane	739..998	CDD:279056	71/266 (27%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	123/240 (51%)
ABCB13	NP_174115.1	PTZ00265	54..1241	CDD:240339	466/1276 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I898
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840