DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mdr49 and ABCB11

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_001322407.1 Gene:ABCB11 / 839353 AraportID:AT1G02520 Length:1278 Species:Arabidopsis thaliana


Alignment Length:1325 Identity:476/1325 - (35%)
Similarity:738/1325 - (55%) Gaps:111/1325 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly     7 SRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFT 71
            |:.|:.|:...||....:......::.||.::...:..|::...:.|......:|:..:::|:  
plant    19 SKSPKEGEETKKEEKSEEKANTVPFYKLFAFADSSDVLLMICGSIGAIGNGMSLPFMTLLFGD-- 81

  Fly    72 SLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATA-------FGIGSLVGSVAM 129
              |:|               .||         |.:||:.|:|..:.       .|:|:|   .|.
plant    82 --LID---------------SFG---------KNQNNKDIVDVVSKVCLKFVYLGLGTL---GAA 117

  Fly   130 FLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYD--TSSGSNFASKMTEDLDKLKEGIGE 192
            ||.:...:....|    |..|||..:|:.:|||||.::|  |::| ....:|:.|...:::.:||
plant   118 FLQVACWMITGER----QAARIRSTYLKTILRQDIGFFDVETNTG-EVVGRMSGDTVLIQDAMGE 177

  Fly   193 KIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANV 257
            |:...:.|:.|||.|.|.||:.||.||||:|:.:|.:..|.:.:|.:....:.:...:|:.||.|
plant   178 KVGKFIQLVSTFVGGFVLAFIKGWLLTLVMLTSIPLLAMAGAAMALIVTRASSRGQAAYAKAATV 242

  Fly   258 VEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGV 322
            ||:....||||.:|:|:::....:.|.:..|..:..::|..:|:|..:.:.:.:...|||||:|.
plant   243 VEQTIGSIRTVASFTGEKQAINSYKKFITSAYKSSIQQGFSTGLGLGVMFFVFFSSYALAIWFGG 307

  Fly   323 TLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDP 387
            .:||      ::.||...::.|:..|:.|:.:||..||.|.|.|...||...:|..|.|...:|.
plant   308 KMIL------EKGYTGGAVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDA 366

  Fly   388 MDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQR 452
            .|..|...|:..|.|..:.:.|.||||||.||..|.::.:..|.|.|.||.||.||||:|.|::|
plant   367 YDVNGKVLEDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVISLIER 431

  Fly   453 FYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAA 517
            ||||::|:|.:||.:|:...:.|:||:||:|.||||||:::|.|||.||:.:||..:|:.|...|
plant   432 FYDPKSGAVLIDGVNLKEFQLKWIRSKIGLVSQEPVLFSSSIMENIAYGKENATVEEIKAATELA 496

  Fly   518 NCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSA 582
            |...||.:||:|.||.|||.|.|:|||||||||||||:::.|::|||||||||||..||:.||.|
plant   497 NAAKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEA 561

  Fly   583 LELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELM-ERRGLYCELVSITQRKEATE 646
            |:......||::|||||||:.|||.|..:..|.:.|:|:|.||: :..|.|.:|:.:.:..:..:
plant   562 LDRVMVNRTTVIVAHRLSTVRNADMIAVIHRGKMVEKGSHSELLKDSEGAYSQLIRLQEINKDVK 626

  Fly   647 ADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSR---------DSGFRASTRRKR 702
            ..| ..:|...:.| ||            ::..|.......|||         .:|....:..:|
plant   627 TSE-LSSGSSFRNS-NL------------KKSMEGTSSVGNSSRHHSLNVLGLTTGLDLGSHSQR 677

  Fly   703 RSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFG----DFFGIL 763
            ..|.......:|.:.|||.|::..||.||...:::|.:|:.::||.|||:|:...    .||   
plant   678 AGQDETGTASQEPLPKVSLTRIAALNKPEIPVLLLGTVAAAINGAIFPLFGILISRVIEAFF--- 739

  Fly   764 SDGDDDVVRAEVLK-----ISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQD 823
                   ..|..||     .::|||.:|:.:.:.:..|.|:|..||.|:..|:|...|...:..:
plant   740 -------KPAHELKRDSRFWAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEKAVHME 797

  Fly   824 IAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTL 888
            :|:||:.:||.|.:.:||::|.:.::...|..:...:|.||:...|:::.|..||:..|:.||.|
plant   798 VAWFDEPQNSSGTMGARLSADATLIRALVGDALSLAVQNVASAASGLIIAFTASWELALIILVML 862

  Fly   889 PLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIA 953
            ||:.::.:::.:|:...:..||:..|||||||.:|:.:||||...|.|.:|:..|.:|       
plant   863 PLIGINGFVQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYKKQ------- 920

  Fly   954 CRRKVR-------FRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWML 1011
            |...::       ..||.|.......|..|..|.|.|..||.:.:..:.::.:|..||...:..:
plant   921 CEGPIKDGIKQGFISGLGFGFSFFILFCVYATSFYAGARLVEDGKTTFNNVFQVFFALTMAAIGI 985

  Fly  1012 GQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPI 1076
            .|:..:||:.:.|.::|..:..:..|.|...:..::. ..:|..:|||...::.|.||.|....|
plant   986 SQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETG-TVLENVKGDIELRHLSFTYPARPDIQI 1049

  Fly  1077 LQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVS 1141
            .:.|.|||:...||||||.|||||||.:.||.|:|||.||.:.|.||...:..|..||.::|||.
plant  1050 FRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLQLKWLRQQMGLVG 1114

  Fly  1142 QEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTS-QLSGGQK 1205
            ||||||:.||..|||||....:..:..|||.||:.:|.|.|||::.|||||.:|:.. |||||||
plant  1115 QEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGERGIQLSGGQK 1179

  Fly  1206 QRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVL 1270
            ||:|||||:|:.||||:|||||||||.|||:|||.|||.....||.:.:||||:|::|||:|.|:
plant  1180 QRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVV 1244

  Fly  1271 KRGVVVEHGTHDELMAL-NKIYANL 1294
            |.||:.|.|||:.|:.: ..:||:|
plant  1245 KNGVIAEKGTHETLIKIEGGVYASL 1269

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 228/615 (37%)
ABC_membrane 116..352 CDD:279056 72/244 (30%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 122/234 (52%)
MdlB 735..1299 CDD:224055 222/578 (38%)
ABC_membrane 739..998 CDD:279056 79/274 (29%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 129/238 (54%)
ABCB11NP_001322407.1 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 162 1.000 Domainoid score I1247
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 876 1.000 Inparanoid score I60
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - mtm951
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - O PTHR24221
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.840

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