Protein Alignment Mdr49 and ABCB11

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_171753.1
• Gene: ABCB11 / 839353
• AraportID: AT1G02520
• Length: 1278
• Species: Arabidopsis thaliana
• Alignment Length: 1325
• Identity: 476/1325 - (35%)
• Similarity: 738/1325 - (55%)
• Gaps: 111/1325 - (8%)

  Fly     7 SRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFT 71
            |:.|:.|:...||....:......::.||.::...:..|::...:.|......:|:..:::|:
plant    19 SKSPKEGEETKKEEKSEEKANTVPFYKLFAFADSSDVLLMICGSIGAIGNGMSLPFMTLLFGD-- 81

  Fly    72 SLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATA-------FGIGSLVGSVAM 129
              |:|               .||         |.:||:.|:|..:.       .|:|:|   .|.
plant    82 --LID---------------SFG---------KNQNNKDIVDVVSKVCLKFVYLGLGTL---GAA 117

  Fly   130 FLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYD--TSSGSNFASKMTEDLDKLKEGIGE 192
            ||.:...:....|    |..|||..:|:.:|||||.::|  |::| ....:|:.|...:::.:||
plant   118 FLQVACWMITGER----QAARIRSTYLKTILRQDIGFFDVETNTG-EVVGRMSGDTVLIQDAMGE 177

  Fly   193 KIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANV 257
            |:...:.|:.|||.|.|.||:.||.||||:|:.:|.:..|.:.:|.:....:.:...:|:.||.|
plant   178 KVGKFIQLVSTFVGGFVLAFIKGWLLTLVMLTSIPLLAMAGAAMALIVTRASSRGQAAYAKAATV 242

  Fly   258 VEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGV 322
            ||:....||||.:|:|:::....:.|.:..|..:..::|..:|:|..:.:.:.:...|||||:|.
plant   243 VEQTIGSIRTVASFTGEKQAINSYKKFITSAYKSSIQQGFSTGLGLGVMFFVFFSSYALAIWFGG 307

  Fly   323 TLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDP 387
            .:||      ::.||...::.|:..|:.|:.:||..||.|.|.|...||...:|..|.|...:|.
plant   308 KMIL------EKGYTGGAVINVIIIVVAGSMSLGQTSPCVTAFAAGQAAAYKMFETIKRKPLIDA 366

  Fly   388 MDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQR 452
            .|..|...|:..|.|..:.:.|.||||||.||..|.::.:..|.|.|.||.||.||||:|.|::|
plant   367 YDVNGKVLEDIRGDIELKDVHFSYPARPDEEIFDGFSLFIPSGATAALVGESGSGKSTVISLIER 431

  Fly   453 FYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAA 517
            ||||::|:|.:||.:|:...:.|:||:||:|.||||||:::|.|||.||:.:||..:|:.|...|
plant   432 FYDPKSGAVLIDGVNLKEFQLKWIRSKIGLVSQEPVLFSSSIMENIAYGKENATVEEIKAATELA 496

  Fly   518 NCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSA 582
            |...||.:||:|.||.|||.|.|:|||||||||||||:::.|::|||||||||||..||:.||.|
plant   497 NAAKFIDKLPQGLDTMVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEA 561

  Fly   583 LELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELM-ERRGLYCELVSITQRKEATE 646
            |:......||::|||||||:.|||.|..:..|.:.|:|:|.||: :..|.|.:|:.:.:..:..:
plant   562 LDRVMVNRTTVIVAHRLSTVRNADMIAVIHRGKMVEKGSHSELLKDSEGAYSQLIRLQEINKDVK 626

  Fly   647 ADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSR---------DSGFRASTRRKR 702
            ..| ..:|...:.| ||            ::..|.......|||         .:|....:..:|
plant   627 TSE-LSSGSSFRNS-NL------------KKSMEGTSSVGNSSRHHSLNVLGLTTGLDLGSHSQR 677

  Fly   703 RSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFG----DFFGIL 763
            ..|.......:|.:.|||.|::..||.||...:::|.:|:.::||.|||:|:...    .||
plant   678 AGQDETGTASQEPLPKVSLTRIAALNKPEIPVLLLGTVAAAINGAIFPLFGILISRVIEAFF--- 739

  Fly   764 SDGDDDVVRAEVLK-----ISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQD 823
                   ..|..||     .::|||.:|:.:.:.:..|.|:|..||.|:..|:|...|...:..:
plant   740 -------KPAHELKRDSRFWAIIFVALGVTSLIVSPTQMYLFAVAGGKLIRRIRSMCFEKAVHME 797

  Fly   824 IAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTL 888
            :|:||:.:||.|.:.:||::|.:.::...|..:...:|.||:...|:::.|..||:..|:.||.|
plant   798 VAWFDEPQNSSGTMGARLSADATLIRALVGDALSLAVQNVASAASGLIIAFTASWELALIILVML 862

  Fly   889 PLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIA 953
            ||:.::.:::.:|:...:..||:..|||||||.:|:.:||||...|.|.:|:..|.:|
plant   863 PLIGINGFVQVKFMKGFSADAKSKYEEASQVANDAVGSIRTVASFCAEEKVMQMYKKQ------- 920

  Fly   954 CRRKVR-------FRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWML 1011
            |...::       ..||.|.......|..|..|.|.|..||.:.:..:.::.:|..||...:..:
plant   921 CEGPIKDGIKQGFISGLGFGFSFFILFCVYATSFYAGARLVEDGKTTFNNVFQVFFALTMAAIGI 985

  Fly  1012 GQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPI 1076
            .|:..:||:.:.|.::|..:..:..|.|...:..::. ..:|..:|||...::.|.||.|....|
plant   986 SQSSTFAPDSSKAKVAAASIFAIIDRKSKIDSSDETG-TVLENVKGDIELRHLSFTYPARPDIQI 1049

  Fly  1077 LQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVS 1141
            .:.|.|||:...||||||.|||||||.:.||.|:|||.||.:.|.||...:..|..||.::|||.
plant  1050 FRDLCLTIRAGKTVALVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLQLKWLRQQMGLVG 1114

  Fly  1142 QEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTS-QLSGGQK 1205
            ||||||:.||..|||||....:..:..|||.||:.:|.|.|||::.|||||.:|:.. |||||||
plant  1115 QEPVLFNDTIRANIAYGKGSEEAATESEIIAAAELANAHKFISSIQQGYDTVVGERGIQLSGGQK 1179

  Fly  1206 QRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVL 1270
            ||:|||||:|:.||||:|||||||||.|||:|||.|||.....||.:.:||||:|::|||:|.|:
plant  1180 QRVAIARAIVKEPKILLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVV 1244

  Fly  1271 KRGVVVEHGTHDELMAL-NKIYANL 1294
            |.||:.|.|||:.|:.: ..:||:|
plant  1245 KNGVIAEKGTHETLIKIEGGVYASL 1269

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	226/608 (37%)
		MdlB	720..1299	CDD:440747	228/593 (38%)
ABCB11	NP_171753.1	PTZ00265	41..1272	CDD:240339	471/1303 (36%)
		MdlB	695..1277	CDD:440747	228/593 (38%)