DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and PGP10

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_172538.1	Gene:	PGP10 / 837611	AraportID:	AT1G10680	Length:	1227	Species:	Arabidopsis thaliana

Alignment Length:	1312	Identity:	456/1312 - (34%)
Similarity:	722/1312 - (55%)	Gaps:	128/1312 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 AGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVD 76
            |.:.:.|..||       |:..||.::...:..|:.:..:.|....|.:|.|.|.:|:..::
plant    14 AAEKEKKRPSV-------SFLKLFSFADFYDCVLMALGSIGACIHGASVPVFFIFFGKLINI--- 68

  Fly    77 RTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLAN 141
              :|:     |:..|             :|.:..:...:..|...|:|...:.:|.:...:....
plant    69 --IGL-----AYLFP-------------QEASHKVAKYSLDFVYLSVVILFSSWLEVACWMHTGE 113

  Fly   142 RIALNQIDRIRKLFLEAMLRQDIAWYDTS-SGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFV 205
            |    |..:|||.:|.:||.|||:.:||. |.....|.:|.::..:::.|.||:...:..|..|:
plant   114 R----QAAKIRKAYLRSMLSQDISLFDTEISTGEVISAITSEILVVQDAISEKVGNFMHFISRFI 174

  Fly   206 IGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFA 270
            .|....|...|:::||.||.||||..|..:.|.:...|..:..|||..|..:.|||...:|||.|
plant   175 AGFAIGFASVWQISLVTLSIVPFIALAGGIYAFVSSGLIVRVRKSYVKANEIAEEVIGNVRTVQA 239

  Fly   271 FSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPD-- 333
            |:|:||....:...|....|.|||.||..|:|......:::|..||.||:  |.|:..:.:.:
plant   240 FTGEEKAVSSYQGALRNTYNYGRKAGLAKGLGLGSLHFVLFLSWALLIWF--TSIVVHKGIANGG 302

  Fly   334 RVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENT 398
            ..:|      .:..|::...:||.|:|.:.....|:||...:|.:|:|.::    |:.|.:..|.
plant   303 ESFT------TMLNVVIAGLSLGQAAPDISTFMRASAAAYPIFQMIERNTE----DKTGRKLGNV 357

  Fly   399 AGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKL 463
            .|.|.|:.:.|.||:||||.|...|...:..|:.||.||.||.||||:|.|::|||:|..|:|.|
plant   358 NGDILFKDVTFTYPSRPDVVIFDKLNFVIPAGKVVALVGGSGSGKSTMISLIERFYEPTDGAVML 422

  Fly   464 DGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPK 528
            ||.|:|.|::.|||..||:|.||||||||||.|||.||:..||..:|..||:.:....||..||:
plant   423 DGNDIRYLDLKWLRGHIGLVNQEPVLFATTIRENIMYGKDDATSEEITNAAKLSEAISFINNLPE 487

  Fly   529 GYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTL 593
            |::|||||:|.|:||||||||:|:||:|:.|.:|||||||||||..|||.||.||:....|.||:
plant   488 GFETQVGERGIQLSGGQKQRISISRAIVKNPSILLLDEATSALDAESEKIVQEALDRVMVGRTTV 552

  Fly   594 VVAHRLSTITNADKIVFLKDGVVAEQGTHEELMER-RGLYCELVSITQRKEATEADEG-----AV 652
            ||||||||:.|||.|..:..|.:.|.|:|:||:.. .|.|..|:.|   :||...:..     .|
plant   553 VVAHRLSTVRNADIIAVVGGGKIIESGSHDELISNPDGAYSSLLRI---QEAASPNLNHTPSLPV 614

  Fly   653 AGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKKKKDKEVVS 717
            :.:||                    .|.|..:|:.|...|..:..|.::               :
plant   615 STKPL--------------------PELPITETTSSIHQSVNQPDTTKQ---------------A 644

  Fly   718 KVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGL--------FFGDFFGILSDGDDDVVRAE 774
            ||:..:|..:..|:|::.:.|.:.|.:.|:..||:.|        ::.|:         :..:.|
plant   645 KVTVGRLYSMIRPDWKYGLCGTLGSFIAGSQMPLFALGIAQALVSYYMDW---------ETTQNE 700

  Fly   775 VLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCS 839
            |.:||::|....::..:.:.::...|...|.::|.|:|::.|..|:..:|.:||...|:...|.|
plant   701 VKRISILFCCGSVITVIVHTIEHTTFGIMGERLTLRVRQKMFSAILRNEIGWFDKVDNTSSMLAS 765

  Fly   840 RLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMK 904
            ||.||.:.::.....|...:|:.:..:|...::.|:.:|:.||:.|.|.||: :|.::..:..|:
plant   766 RLESDATLLRTIVVDRSTILLENLGLVVTAFIISFILNWRLTLVVLATYPLI-ISGHISEKIFMQ 829

  Fly   905 --SAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFAL 967
              ....:||.: :|:.:|.|:|:|||||...|.|.:|||.|.:::........|:.:..|:::.:
plant   830 GYGGNLSKAYL-KANMLAGESISNIRTVVAFCAEEKVLDLYSKELLEPSERSFRRGQMAGILYGV 893

  Fly   968 GQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNV---NDAILSAG 1029
            .|...|.:||::::||.||:.:...::|.::|....||..:.::|:.||.||::   |..::|..
plant   894 SQFFIFSSYGLALWYGSILMEKGLSSFESVMKTFMVLIVTALVMGEVLALAPDLLKGNQMVVSVF 958

  Fly  1030 RLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVG 1094
            .|:|  :||....:..:...|.    ||.|..:.|.|.||:|....|....||.:....::||||
plant   959 ELLD--RRTQVVGDTGEELSNV----EGTIELKGVHFSYPSRPDVTIFSDFNLLVPSGKSMALVG 1017

  Fly  1095 PSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGN 1159
            .||||||:.:.|:||:|||.:|.:.:.|....:..|.:||..:|||.|||.||..||.|||.||
plant  1018 QSGSGKSSVLSLVLRFYDPTAGIIMIDGQDIKKLKLKSLRRHIGLVQQEPALFATTIYENILYG- 1081

  Fly  1160 NFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTS-QLSGGQKQRIAIARALVRNPKILIL 1223
              ::..|..|::||||.:|.|:|||:||:||.|::|:.. |:||||:||||||||:::||:||:|
plant  1082 --KEGASESEVMEAAKLANAHSFISSLPEGYSTKVGERGIQMSGGQRQRIAIARAVLKNPEILLL 1144

  Fly  1224 DEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMA-L 1287
            ||||||||:|||:|||||||.....||.:.:||||:|::|:|:|.|::.|.::|.|:|:.|:. .
plant  1145 DEATSALDVESERVVQQALDRLMRDRTTVVVAHRLSTIKNSDMISVIQDGKIIEQGSHNILVENK 1209

  Fly  1288 NKIYANLYLMQQ 1299
            |..|:.|..:||
plant  1210 NGPYSKLISLQQ 1221

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	229/609 (38%)
		ABC_membrane	116..352	CDD:279056	72/238 (30%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	128/234 (55%)
		MdlB	735..1299	CDD:224055	204/578 (35%)
		ABC_membrane	739..998	CDD:279056	69/268 (26%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	117/240 (49%)
PGP10	NP_172538.1	PTZ00265	40..1221	CDD:240339	447/1277 (35%)
		ABC_membrane	50..313	CDD:279056	81/297 (27%)
		ABC_MTABC3_MDL1_MDL2	361..599	CDD:213216	130/240 (54%)
		ABC_membrane	666..935	CDD:279056	72/279 (26%)
		ABC_MTABC3_MDL1_MDL2	982..1220	CDD:213216	117/240 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69084
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840