DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and Abcb11

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_113948.1	Gene:	Abcb11 / 83569	RGDID:	619930	Length:	1321	Species:	Rattus norvegicus

Alignment Length:	1345	Identity:	519/1345 - (38%)
Similarity:	774/1345 - (57%)	Gaps:	112/1345 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGE 69
            ::|||..    ::|||.:     :..:|:|||:|:..:.:|:::..:.|.......|..:||:|.
  Rat    30 KKSRLQD----KMKEGDI-----RVGFFELFRFSSSKDIWLMLMGGVCALLHGMAQPGILIIFGI 85

  Fly    70 FTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAII----------DDATAFGI---- 120
            .|.:.:...:               ..|:|....|...|..|:          .:.|..|:
  Rat    86 MTDIFIKYDI---------------ERQELEIPGKACVNNTIVWINSSFHQNMTNGTVCGLVDIE 135

  Fly   121 ------GSLVGSVAMFLLIT--LAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFAS 177
                  ..:...|.|.:||.  ..|.|.......||.|:||::...::|.:|.|:|.:|.....|
  Rat   136 SEMIKFSGIYAGVGMTVLILGYFQIRLWVITGARQIRRMRKIYFRRIMRMEIGWFDCTSVGELNS 200

  Fly   178 KMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGS 242
            :..:|::|:.:.|.:::...:..:.|.:.|::..|..|||||||:|:..|.|....:|:......
  Rat   201 RFADDIEKINDAIADQLAHFLQRMSTAMCGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSIAK 265

  Fly   243 LAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSW 307
            ..|.|||:|:.|.::.:||.|.||||.||.|:.||.||:.|.|:.|:..|..||:..|......|
  Rat   266 FTELELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLVFAQRWGIWKGMVMGFFTGYMW 330

  Fly   308 LIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAG 372
            .:|:.|.|||.|||.||:|||.:     |||..||.:...||:.|.|:|.||..:|..:...:|.
  Rat   331 CLIFFCYALAFWYGSTLVLDEEE-----YTPGTLVQIFLCVILAAMNIGHASSCLEIFSTGCSAA 390

  Fly   373 QTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVG 437
            ..:|..|||...:|.|...|.:.:...|.|.|..:.|.||:||||:||..|::.:.||:|.|.||
  Rat   391 TNIFQTIDRQPVIDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPDVKILDNLSMVIKPGETTALVG 455

  Fly   438 ASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGR 502
            :||.||||.:||:||||||..|.|.|||.|:|:||:.|||.|||:|.||||||:|||.||||:||
  Rat   456 SSGAGKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRFGR 520

  Fly   503 PSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEA 567
            ..||..||.:||:.||.::||..||:.:||.|||.|.|:|||||||:||||||:|.|::||||.|
  Rat   521 EDATMEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRNPKILLLDMA 585

  Fly   568 TSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLY 632
            |||||..||.|||.||.....|.|.:.|||||||:..||.|:..:.||..|:||||||:||:|:|
  Rat   586 TSALDNESEARVQEALNKIQHGHTIISVAHRLSTVRAADVIIGFEHGVAVERGTHEELLERKGVY 650

  Fly   633 CELVSITQR-----KEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDS 692
            ..||::..:     ||.:...:.|..|..|:::                       .:.||.|||
  Rat   651 FMLVTLQSQGDNAHKETSIMGKDATEGGTLERT-----------------------FSRGSYRDS 692

  Fly   693 GFRASTRRKRRSQ-----------------RRKKKKDKEV----VSKVSFTQLMKLNSPEWRFIV 736
             .|||.|::.:||                 ..|..||.:|    |......:::|.|.|||.:|:
  Rat   693 -LRASIRQRSKSQLSLLTHDPPLAVADHKSSYKDSKDNDVLVEEVEPAPVRRILKYNIPEWHYIL 756

  Fly   737 VGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFT 801
            ||.:::.::||..|::.|.|....|..|..|.:..|:|:..:.:.||.:|.::.....||.|.|.
  Rat   757 VGSLSAAINGAVTPIYSLLFSQLLGTFSLLDKEQQRSEIHSMCLFFVILGCVSIFTQFLQGYTFA 821

  Fly   802 TAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATL 866
            .:|..:|.||||..|..::||||.:|||.||:.|.|.:|||:|.|.||||||::||.|:.:...:
  Rat   822 KSGELLTKRLRKFGFKAMLGQDIGWFDDLRNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNI 886

  Fly   867 VVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVN 931
            :..:::.|.|||:.:|:..:..|.:.||..::.:.:...|.:.|.::|:|.|:..||::|||||.
  Rat   887 IAALLIAFFFSWKLSLIITIFFPFLALSGAVQTKMLTGFASQDKQALEKAGQITSEALSNIRTVA 951

  Fly   932 GLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYED 996
            |:.:|.:.:..:..::........||....||.||..|...|||...:..|||.|:|.|.:.:..
  Rat   952 GIGVEGRFIKAFEVELQTSYKTAVRKANIYGLCFAFSQGIAFLANSAAYRYGGYLIAYEGLGFSH 1016

  Fly   997 IIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTV----EKSEG 1057
            :.:|..::...:..:|:..:|.|:...|.:||.|...|..|     .||.:.|:..    :..:|
  Rat  1017 VFRVVSSVALSATAVGRTFSYTPSYAKAKISAARFFQLLDR-----KPPINVYSEAGEKWDNFQG 1076

  Fly  1058 DIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSG 1122
            .|.:.:..|.||:|....:|.||::::....|:|.||.||.||||.:|||.|:|||..|:|.:.|
  Rat  1077 KIDFIDCKFTYPSRPDIQVLNGLSVSVNPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDG 1141

  Fly  1123 VPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALP 1187
            ..|.:..:..|||.:|:|||||||||.:|.:||.||:|.: ::|::..|.|||::.:|:|:.:||
  Rat  1142 HDSKKVNIQFLRSNIGIVSQEPVLFDCSIMDNIKYGDNTK-EISVERAIAAAKQAQLHDFVMSLP 1205

  Fly  1188 QGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTC 1251
            :.|:|.:| :.||||.|:|||||||||:||:||||:|||||||||.||||.||.|||:||.||||
  Rat  1206 EKYETNVGIQGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQTALDKAREGRTC 1270

  Fly  1252 LTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYL 1296
            :.|||||:|::|:|:|.|:.:|||:|.|||::|||....|..|.:
  Rat  1271 IVIAHRLSTIQNSDIIAVVSQGVVIEKGTHEKLMAQKGAYYKLVI 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	256/627 (41%)
		ABC_membrane	116..352	CDD:279056	84/247 (34%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	139/233 (60%)
		MdlB	735..1299	CDD:224055	230/567 (41%)
		ABC_membrane	739..998	CDD:279056	87/258 (34%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	126/239 (53%)
Abcb11	NP_113948.1	PTZ00265	150..1314	CDD:240339	492/1198 (41%)
Abcb11	NP_113948.1	Interaction with HAX1. /evidence=ECO:0000269\|PubMed:15159385	651..674		4/22 (18%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2784
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	8.730