DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB7

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_199466.1	Gene:	ABCB7 / 834697	AraportID:	AT5G46540	Length:	1248	Species:	Arabidopsis thaliana

Alignment Length:	1308	Identity:	488/1308 - (37%)
Similarity:	724/1308 - (55%)	Gaps:	123/1308 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALP 91
            ::.:::.||.::.|.:..|:|:..|.|.|.....|:..|:.|:..::.
plant    16 QRIAFYKLFTFADRYDIVLMVIGTLSAMANGLTQPFMSILMGQLINVF----------------- 63

  Fly    92 MFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFL 156
               |.....:..||.:..|:     .|...:....|..||.::..:....|    |..|||:|:|
plant    64 ---GFSDHDHVFKEVSKVAV-----KFLYLAAYAGVVSFLQVSCWMVTGER----QSTRIRRLYL 116

  Fly   157 EAMLRQDIAWYDTSSGS-NFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTL 220
            :.:|||||.::||.:.: ....:|:.|...:::.:|||:.....|:.:||.|...||:.|.||||
plant   117 KTILRQDIGFFDTETNTGEVIGRMSGDTILIQDSMGEKVGKFTQLVSSFVGGFTVAFIVGMKLTL 181

  Fly   221 VVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLL 285
            .:|.|||.|:.....:..:....|::...:|::|.|||::....||||.||:|:::...::.|.|
plant   182 ALLPCVPLIVGTGGAMTYIMSKKAQRVQLAYTEAGNVVQQAVGSIRTVVAFTGEKQSMGKYEKKL 246

  Fly   286 IPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIM 350
            ..|..:..|:|||||:|..:..:::|.....|||||.      |.:.::.||...::.|:.:::.
plant   247 EIAYKSMVKQGLYSGLGIGIMMVVVYCTYGFAIWYGA------RQIIEKGYTGGQVMNVITSILT 305

  Fly   351 GAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARP 415
            |...||...|.:.:.|..|||...:|..|.|..::|..|..|...|...|.|....:.|||||||
plant   306 GGMALGQTLPSLNSFAAGTAAAYKMFETIKRKPKIDAYDMSGEVLEEIKGDIELRDVYFRYPARP 370

  Fly   416 DVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQI 480
            ||:|..|.::.|..|.|||.||.||.||||:|.|::||||||:|.|.:||.||:...|.|:||:|
plant   371 DVQIFVGFSLTVPNGMTVALVGQSGSGKSTVISLIERFYDPESGEVLIDGIDLKKFQVKWIRSKI 435

  Fly   481 GVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQ 545
            |:|.|||:||||||.|||.||:..|:..:|..|.:.||..:||.:||:|.:|.|||.|.|:||||
plant   436 GLVSQEPILFATTIRENIVYGKKDASDQEIRTALKLANASNFIDKLPQGLETMVGEHGTQLSGGQ 500

  Fly   546 KQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVF 610
            |||||||||:::.|::|||||||||||..||:.||.||.......||:||||||:||..||.|..
plant   501 KQRIAIARAILKNPKILLLDEATSALDAESERIVQDALVKLMLSRTTVVVAHRLTTIRTADMIAV 565

  Fly   611 LKDGVVAEQGTHEELM-ERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEED 674
            ::.|.|.|:|||:|:: :..|.|.:||.:         .||:                    :::
plant   566 VQQGKVIEKGTHDEMIKDPEGTYSQLVRL---------QEGS--------------------KKE 601

  Fly   675 EEEDEEPE-----LQTSGSSRDSGFRAST--------------------RRKRRSQRRKKKKDKE 714
            |..|:|||     |:...|...:|..:.|                    .....::.:..||.||
plant   602 EAIDKEPEKCEMSLEIESSDSQNGIHSGTLTSPSGLPGVISLDQTEEFHENISSTKTQTVKKGKE 666

  Fly   715 VVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKIS 779
                ||..:|..||.||...:::|.:|:|:||..||:.||.......|..: ..:.::.:.|..:
plant   667 ----VSLRRLAHLNKPEISVLLLGSLAAVIHGIVFPVQGLLLSRTIRIFFE-PSNKLKNDSLFWA 726

  Fly   780 MIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASD 844
            :|||.:||...:...||.|:|..||.|:..|:|..:|..::.|||::|||.:||.|.:.:||::|
plant   727 LIFVALGLTDLIVIPLQNYLFAIAGAKLIKRIRSLSFDRVLHQDISWFDDTKNSSGVIGARLSTD 791

  Fly   845 CSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKA 909
            .|.|:...|..:|.::|.:||::...::.|..:|...|:.|:..|::....|.:.:||.....||
plant   792 ASTVKSIVGDVLGLIMQNMATIIGAFIIAFTANWLLALMALLVAPVMFFQGYYQIKFITGFGAKA 856

  Fly   910 KASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFR-GLVFALGQAAPF 973
            :...|||||||.:|:::||||...|.|.:|:|.|.::.|.     .::..|: |||..|.....:
plant   857 RGKYEEASQVASDAVSSIRTVASFCAEDKVMDLYQEKCDE-----PKQQGFKLGLVSGLCYGGSY 916

  Fly   974 LAY----GISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDL 1034
            ||.    .:....|..|:...|..:.:..:|..||...:..:.|....||::|.|..||..:.|:
plant   917 LALYVIESVCFLGGSWLIQNRRATFGEFFQVFFALTLTAVGVTQTSTMAPDINKAKDSAASIFDI 981

  Fly  1035 FKRTSTQPNPPQSPYNTVEKS------EGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALV 1093
            .   .::|....|.    ||.      .|||..::|.|.||.|....|...|.|||....|||||
plant   982 L---DSKPKIDSSS----EKGTILPIVHGDIELQHVSFRYPMRPDIQIFSDLCLTISSGQTVALV 1039

  Fly  1094 GPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYG 1158
            |.|||||||.:.||.|:|||.||.:.|..|......|..||.::||||||||||:.||..|||||
plant  1040 GESGSGKSTVISLLERFYDPDSGKILLDQVEIQSLKLSWLREQMGLVSQEPVLFNETIGSNIAYG 1104

  Fly  1159 NNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTS-QLSGGQKQRIAIARALVRNPKILI 1222
            .  ....:.:|||.|||.:|:|||||:|||||:|.:|:.. |||||||||||||||::::||||:
plant  1105 K--IGGATEEEIITAAKAANVHNFISSLPQGYETSVGERGVQLSGGQKQRIAIARAILKDPKILL 1167

  Fly  1223 LDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMAL 1287
            |||||||||.|||:|||.|||:....||.:.:||.|||:::||:|.|:|.||:.|.|.|:.||.:
plant  1168 LDEATSALDAESERVVQDALDQVMVNRTTVVVAHLLTTIKDADMIAVVKNGVIAESGRHETLMEI 1232

  Fly  1288 N-KIYANL 1294
            : ..||:|
plant  1233 SGGAYASL 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	234/607 (39%)
		ABC_membrane	116..352	CDD:279056	72/236 (31%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	129/234 (55%)
		MdlB	735..1299	CDD:224055	232/573 (40%)
		ABC_membrane	739..998	CDD:279056	82/263 (31%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	132/238 (55%)
ABCB7	NP_199466.1	PTZ00265	16..1241	CDD:240339	488/1308 (37%)
		ABC_membrane	39..308	CDD:279056	83/303 (27%)
		ABC_MTABC3_MDL1_MDL2	357..595	CDD:213216	131/246 (53%)
		ABC_membrane	688..956	CDD:279056	85/273 (31%)
		ABC_MTABC3_MDL1_MDL2	1005..1241	CDD:213216	132/238 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840