DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr49 and ABCB29

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_196011.1	Gene:	ABCB29 / 830269	AraportID:	AT5G03910	Length:	634	Species:	Arabidopsis thaliana

Alignment Length:	513	Identity:	168/513 - (32%)
Similarity:	259/513 - (50%)	Gaps:	33/513 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   780 MIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERN-SVGALCSRLAS 843
            ::..|:.|...:...||......|.:....::|..|:..::.:::.:|:.... |.|.:..|:.:
plant   119 LVLAGLVLAKVVAYYLQQAFLWEAALNTVYKIRVFAYRRVLERELEFFEGGNGISSGDIAYRITA 183

  Fly   844 DCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSV-YLEGRF--IMKS 905
            :.|.|.....|.:.|::.:...:.|......|.|...||::.:.:|.|.|.: ||..|.  |.:.
plant   184 EASEVADTIYALLNTVVPSAIQISVMTAHMIVASPALTLVSAMVIPSVALLIAYLGDRLRKISRK 248

  Fly   906 AQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACR-RKVRFRGL------ 963
            ||.|.|.:.......:.||..::..|....|    ....|:..|.|:..| :|.:.:.|
plant   249 AQIASAQLSTYLNEVLPAILFVKANNAEISE----SVRFQRFARADLDERFKKKKMKSLIPQIVQ 309

  Fly   964 VFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIF---GSWMLGQALAYAPNVNDAI 1025
            |..||..:.|..       |.:::|...::...|:....:|.|   ....||:|.........||
plant   310 VMYLGSLSIFCV-------GAVILAGSSLSSSAIVSFVASLAFLIDPVQDLGKAYNELKQGEPAI 367

  Fly  1026 LSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTV 1090
               .||.||....|.....|::  ..:||..|::...::.|:|.... .|:|.||||.||...||
plant   368 ---ERLFDLTSLESKVIERPEA--IQLEKVAGEVELCDISFKYDENM-LPVLDGLNLHIKAGETV 426

  Fly  1091 ALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENI 1155
            |||||||.||:|.::||||.|:|.|||:.:..:...:..|::||..:|||||:..||..|||:||
plant   427 ALVGPSGGGKTTLIKLLLRLYEPSSGSIIIDKIDIKDIKLESLRKHVGLVSQDTTLFSGTIADNI 491

  Fly  1156 AYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPK 1219
            .| .:....:.|:.:..|||.:|...||..||:||:|.:| :.|.||||||||:||||||.:...
plant   492 GY-RDLTTGIDMKRVELAAKTANADEFIRNLPEGYNTGVGPRGSSLSGGQKQRLAIARALYQKSS 555

  Fly  1220 ILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVE 1277
            ||||||||||||..||.:|::||:......|.:.|||||.||..|..:.:::||.:.|
plant   556 ILILDEATSALDSLSELLVREALERVMQDHTVIVIAHRLETVMMAQRVFLVERGKLKE 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055
		ABC_membrane	116..352	CDD:279056
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216
		MdlB	735..1299	CDD:224055	168/513 (33%)
		ABC_membrane	739..998	CDD:279056	47/228 (21%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	104/220 (47%)
ABCB29	NP_196011.1	MdlB	77..613	CDD:224055	167/511 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900