DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB2

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_194326.2	Gene:	ABCB2 / 828702	AraportID:	AT4G25960	Length:	1273	Species:	Arabidopsis thaliana

Alignment Length:	1292	Identity:	451/1292 - (34%)
Similarity:	707/1292 - (54%)	Gaps:	101/1292 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 KYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPM 92
            |.|...||.::...:..|:.:..:.|....|.:|.|.|.:|:..::     :|:     |:..|
plant    59 KVSLLKLFSFADFYDCVLMTLGSVGACIHGASVPIFFIFFGKLINI-----IGL-----AYLFP- 112

  Fly    93 FGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLE 157
                       |:.:::     ...:.:..:..|||:.....|.:.........|..::|:.:|.
plant   113 -----------KQASHR-----VAKYSLDFVYLSVAILFSSWLEVACWMHTGERQAAKMRRAYLR 161

  Fly   158 AMLRQDIAWYDT-SSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLV 221
            :||.|||:.:|| :|.....|.:|.|:..:::.:.||:...:..|..|:.|....|...|:::||
plant   162 SMLSQDISLFDTEASTGEVISAITSDILVVQDALSEKVGNFLHYISRFIAGFAIGFTSVWQISLV 226

  Fly   222 VLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLI 286
            .||.||.|..|..:.|.:...|..:..|||..|..:.|||...:|||.||:|:|:....:.:.|
plant   227 TLSIVPLIALAGGIYAFVAIGLIARVRKSYIKAGEIAEEVIGNVRTVQAFTGEERAVRLYREAL- 290

  Fly   287 PAENT---GRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPD--RVYTPAVLVIVLF 346
              |||   |||.||..|:|......:::|..||.:|:  |.::..:|:.|  :.:|      .:.
plant   291 --ENTYKYGRKAGLTKGLGLGSMHCVLFLSWALLVWF--TSVVVHKDIADGGKSFT------TML 345

  Fly   347 AVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRY 411
            .|::...:||.|:|.:.|...|.||...:|.:|:|.:......:.|.:.....|||:|:...|.|
plant   346 NVVIAGLSLGQAAPDISAFVRAKAAAYPIFKMIERNTVTKTSAKSGRKLGKVDGHIQFKDATFSY 410

  Fly   412 PARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWL 476
            |:||||.|...|.:.:..|:.||.||.||.||||:|.|::|||:|.:|:|.|||.::..|::.||
plant   411 PSRPDVVIFDRLNLAIPAGKIVALVGGSGSGKSTVISLIERFYEPISGAVLLDGNNISELDIKWL 475

  Fly   477 RSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQI 541
            |.|||:|.|||.||||||.|||.||:..||..:|.:||:.:....||..||:|::|||||:|.|:
plant   476 RGQIGLVNQEPALFATTIRENILYGKDDATAEEITRAAKLSEAISFINNLPEGFETQVGERGIQL 540

  Fly   542 SGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNAD 606
            ||||||||||:||:|:.|.:|||||||||||..|||.||.||:....|.||:||||||||:.|||
plant   541 SGGQKQRIAISRAIVKNPSILLLDEATSALDAESEKSVQEALDRVMVGRTTVVVAHRLSTVRNAD 605

  Fly   607 KIVFLKDGVVAEQGTHEELMER-RGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDD 670
            .|..:.:|.:.|.|.||.|:.. .|.|..|:.:   :|...........|.|.:..::.
plant   606 IIAVVHEGKIVEFGNHENLISNPDGAYSSLLRL---QETASLQRNPSLNRTLSRPHSIK------ 661

  Fly   671 DEEDEEEDEEPELQTSGSSRD-SGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRF 734
                             .||: |..|:|...:|.|..|....|.....||:..:|..:..|:|.:
plant   662 -----------------YSRELSRTRSSFCSERESVTRPDGADPSKKVKVTVGRLYSMIRPDWMY 709

  Fly   735 IVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYM 799
            .|.|.|.:.:.|:..||:.|...........|.|: .:.|:.||:::|....::..:...::...
plant   710 GVCGTICAFIAGSQMPLFALGVSQALVSYYSGWDE-TQKEIKKIAILFCCASVITLIVYTIEHIC 773

  Fly   800 FTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVA 864
            |.|.|.::|.|:|:..|..|:..:|.:||:..|:...|.|||.||.:.::.....|...:||.:.
plant   774 FGTMGERLTLRVRENMFRAILKNEIGWFDEVDNTSSMLASRLESDATLLKTIVVDRSTILLQNLG 838

  Fly   865 TLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMK--SAQKAKASIEEASQVAVEAITNI 927
            .:|...::.|:.:|:.||:.|.|.||| :|.::..:..|:  .....||.: :|:.:|.|:::||
plant   839 LVVTSFIIAFILNWRLTLVVLATYPLV-ISGHISEKLFMQGYGGDLNKAYL-KANMLAGESVSNI 901

  Fly   928 RTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERM 992
            |||...|.|.::|:.|.:::.....:..|:.:..||.:.:.|...|.:||::::||..|:.:...
plant   902 RTVAAFCAEEKILELYSRELLEPSKSSFRRGQIAGLFYGVSQFFIFSSYGLALWYGSTLMDKGLA 966

  Fly   993 NYEDIIKVAEALIFGSWMLGQALAYAPNV---NDAILSAGRLMD----LFKRTSTQPNPPQSPYN 1050
            .::.::|....||..:..:|:.||.||::   |..:.|...::|    :...||.:.|
plant   967 GFKSVMKTFMVLIVTALAMGETLALAPDLLKGNQMVASVFEILDRKTQIVGETSEELN------- 1024

  Fly  1051 TVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVS 1115
               ..||.|..:.|.|.||:|....|.:..:|.::...::||||.||||||:.:.|:||:|||.:
plant  1025 ---NVEGTIELKGVHFSYPSRPDVVIFRDFDLIVRAGKSMALVGQSGSGKSSVISLILRFYDPTA 1086

  Fly  1116 GSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIH 1180
            |.|.:.|....:..|..||..:|||.|||.||..||.|||.|||   :..|..|::|:|..:|.|
plant  1087 GKVMIEGKDIKKLDLKALRKHIGLVQQEPALFATTIYENILYGN---EGASQSEVVESAMLANAH 1148

  Fly  1181 NFISALPQGYDTRLGKTS-QLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDE 1244
            :||::||:||.|::|:.. |:||||:||||||||:::||.||:|||||||||:|||:|||||||.
plant  1149 SFITSLPEGYSTKVGERGVQMSGGQRQRIAIARAILKNPAILLLDEATSALDVESERVVQQALDR 1213

  Fly  1245 ARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKI--YANLYLMQQ 1299
            ..:.||.:.:||||:|::|||.|.||..|.:||.|:|.:|: |||.  |..|..:||
plant  1214 LMANRTTVVVAHRLSTIKNADTISVLHGGKIVEQGSHRKLV-LNKSGPYFKLISLQQ 1269

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	224/612 (37%)
		ABC_membrane	116..352	CDD:279056	69/241 (29%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	127/234 (54%)
		MdlB	735..1299	CDD:224055	206/575 (36%)
		ABC_membrane	739..998	CDD:279056	68/260 (26%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	120/241 (50%)
ABCB2	NP_194326.2	PTZ00265	76..1269	CDD:240339	445/1273 (35%)
		ABC_membrane	86..349	CDD:279056	78/300 (26%)
		ABC_MTABC3_MDL1_MDL2	401..639	CDD:213216	128/240 (53%)
		ABC_membrane	714..983	CDD:279056	71/271 (26%)
		ABC_MTABC3_MDL1_MDL2	1030..1268	CDD:213216	120/241 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I898
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69084
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.840