Protein Alignment Mdr49 and ABCB28

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_194275.2
• Gene: ABCB28 / 828650
• AraportID: AT4G25450
• Length: 714
• Species: Arabidopsis thaliana
• Alignment Length: 619
• Identity: 191/619 - (30%)
• Similarity: 309/619 - (49%)
• Gaps: 83/619 - (13%)

  Fly    81 VGTSSPAFALPMFGGG--QQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFL----LITLAIDL 139
            :|.|:...::|:|.|.  :.|.....|.             :..|:..:|:..    :.|:|. :
plant   117 LGCSTCTLSMPVFSGRFFEVLIGVRPEP-------------LWRLLSKIAVLYSLEPIFTIAF-V 167

  Fly   140 ANRIAL--NQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDL--------DKLKEGIGEKI 194
            .|..|:  |.:..:|......:|.|...::|..........:|.||        |.:....|.:.
plant   168 TNMTAIWENVMAILRAQIFRRVLIQKAEFFDKYKVGELTGLLTSDLGALNSIVNDNISRDRGFRA 232

  Fly   195 VIVVF--LIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANV 257
            ...||  :.:.|.:....|.|.|  |.::.:|.:..:...::|.......||:..:      ::.
plant   233 FTEVFGTICILFTLSPQLAPVLG--LLMLAVSVLVAVYKRSTVPVYKSHGLAQATM------SDC 289

  Fly   258 VEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIW--- 319
            |.|.||.||||.:|||::::...||..::..:.:|.|.|.:..:..:::.:.:|:.: ||::
plant   290 VSETFSAIRTVRSFSGEKRQMSIFGSQILAYKLSGLKLGTFKSINESITRVAVYISL-LALYCLG 353

  Fly   320 -------------------YGVTLILDERDLP-------------DRVYTPAVLVIVLFAVIMGA 352
                               |..||....:.|.             ||:.:....|.:..|:..|.
plant   354 GSKVKTGELAVGTVVSFIGYTFTLTFAVQGLVNTFGDLRGTFAAIDRINSILNAVDIDEALAYGL 418

  Fly   353 Q-NLGFASPHVEAIAVATAAGQTLFNI--IDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPAR 414
            : ::.......|.:.:..:||..: ||  :|:....:.......|....||.:..:.:.|.||.|
plant   419 ERDIHTKKVQDENLKLFLSAGPNV-NIRHLDKYYMSNLKSTNNLRTLTWAGDVCLDDVHFAYPLR 482

  Fly   415 PDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQ 479
            |||::|.||::.:..|...|.||:||.||||::||:.|||:|..|.:.:.|.|:|..:.......
plant   483 PDVKVLDGLSLTLNSGTVTALVGSSGAGKSTIVQLLARFYEPTQGRITVGGEDVRMFDKSEWAKV 547

  Fly   480 IGVVGQEPVLFATTIGENIRYGRPS--ATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQIS 542
            :.:|.||||||:.::.|||.||.|:  .::.||.|||:|||.||||..||:||||.|||:|..:|
plant   548 VSIVNQEPVLFSLSVAENIAYGLPNEHVSKDDIIKAAKAANAHDFIISLPQGYDTLVGERGGLLS 612

  Fly   543 GGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADK 607
            |||:||:||||:|::...:|:|||||||||..||:.|||||....:..||||:||||||:.:|::
plant   613 GGQRQRVAIARSLLKNAPILILDEATSALDAVSERLVQSALNRLMKDRTTLVIAHRLSTVQSANQ 677

  Fly   608 IVFLKDGVVAEQGTHEELMERRGLYCELVSITQR 641
            |....||.:.|.|||.||:.::|.|..||. |||
plant   678 IAVCSDGKIIELGTHSELVAQKGSYASLVG-TQR 710

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	191/619 (31%)
		MdlB	720..1299	CDD:440747
ABCB28	NP_194275.2	MdlB	94..709	CDD:440747	188/616 (31%)