Protein Alignment Mdr49 and ABCB5

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_192092.1
• Gene: ABCB5 / 826974
• AraportID: AT4G01830
• Length: 1230
• Species: Arabidopsis thaliana
• Alignment Length: 1310
• Identity: 465/1310 - (35%)
• Similarity: 729/1310 - (55%)
• Gaps: 121/1310 - (9%)

  Fly    17 LKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGV 81
            :|:|::...|:...::.||.:|...:..|::|..:.|.|.....|...:::||    |:|   .:
plant     1 MKKGNLEANTKTVPFYKLFFFSDSTDVLLMIVGSIGAIANGVCSPLMTLLFGE----LID---AM 58

  Fly    82 GTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATA-------FGIGSLVGSVAMFLLITLAIDL 139
            |.:                     :||:.|::..:.       .|:|:|   .|.||.:...:..
plant    59 GPN---------------------QNNEEIVERVSKVCLSLVYLGLGAL---GAAFLQVACWMIT 99

  Fly   140 ANRIALNQIDRIRKLFLEAMLRQDIAWYDTS-SGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMT 203
            ..|    |..|||.|:|:.:|||||.::|.. :......:|:.|...:.:.:|||:...:.||.|
plant   100 GER----QAARIRSLYLKTILRQDIGFFDVEMTTGEVVGRMSGDTVLILDAMGEKVGKFIQLIST 160

  Fly   204 FVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTV 268
            ||.|.|.||:.||.||||:|:.:|.:..:.:.:|.:....:.:|..:|:.|:||||:....||||
plant   161 FVGGFVIAFLRGWLLTLVMLTSIPLLAMSGAAIAIIVTRASSQEQAAYAKASNVVEQTLGSIRTV 225

  Fly   269 FAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPD 333
            .:|:|:::....:.:|:..|..:..|:|..:|:|..:.:|:.:...||..|:|..:||      .
plant   226 ASFTGEKQAMSSYKELINLAYKSNVKQGFVTGLGLGVMFLVFFSTYALGTWFGGEMIL------R 284

  Fly   334 RVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENT 398
            :.||...::.|:..|:..:..||.|||.:.|.....||...:|..|:|...:|..|..|...|:.
plant   285 KGYTGGAVINVMVTVVSSSIALGQASPCLTAFTAGKAAAYKMFETIEREPLIDTFDLNGKVLEDI 349

  Fly   399 AGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKL 463
            .|.|....:.|.|||||..|:..|.::.:..|.|.|.||.||.||||:|.|::|||||.:|.|.:
plant   350 RGEIELRDVCFSYPARPKEEVFGGFSLLIPSGTTTALVGESGSGKSTVISLIERFYDPNSGQVLI 414

  Fly   464 DGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPK 528
            ||.||:...:.|:|.:||:|.||||||:::|.|||.||:..||..:|:.|::.||...||.:||.
plant   415 DGVDLKEFQLKWIRGKIGLVSQEPVLFSSSIMENIGYGKEGATVEEIQAASKLANAAKFIDKLPL 479

  Fly   529 GYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTL 593
            |.:|.|||.|.|:|||||||||||||:::.|::|||||||||||..||:.||.||:......||:
plant   480 GLETLVGEHGTQLSGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRIMVNRTTV 544

  Fly   594 VVAHRLSTITNADKIVFLKDGVVAEQGTHEELM-ERRGLYCELV---SITQRKEATEADEGAVAG 654
            :|||||||:.|||.|..:..|.:.|:|:|.||: :..|.|.:|:   .|.:..:..|..:|::
plant   545 IVAHRLSTVRNADIIAVIHRGKIVEEGSHSELLKDHEGAYSQLLRLQEINKESKRLEISDGSI-- 607

  Fly   655 RPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRS--------QRRKKKK 711
                                          :|||||.:.   |||:...|        .:...|.
plant   608 ------------------------------SSGSSRGNN---STRQDDDSFSVLGLLAGQDSTKM 639

  Fly   712 DKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVL 776
            .:|:..|||||::..||.||...:::|.:...::|..||::|:.|............::.| :..
plant   640 SQELSQKVSFTRIAALNKPEIPILILGTLVGAVNGTIFPIFGILFAKVIEAFFKAPHELKR-DSR 703

  Fly   777 KISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRL 841
            ..|||||.:|:.|.:......|:|..||.::..|:|...|..::..::.:||:..||.||:.:||
plant   704 FWSMIFVLLGVAAVIVYPTTNYLFAIAGGRLIRRIRSMCFEKVVHMEVGWFDEPGNSSGAMGARL 768

  Fly   842 ASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSA 906
            ::|.:.::...|..:...::.||:||.|:::.|..||:..::.||.:|.:.::.|::.:|:...:
plant   769 SADAALIRTLVGDSLCLSVKNVASLVTGLIIAFTASWEVAIIILVIIPFIGINGYIQIKFMKGFS 833

  Fly   907 QKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRF---RGLVFALG 968
            ..|||..|||||||.:|:.:||||...|.|.:|::.|.::       |...::.   :||:..:|
plant   834 ADAKAKYEEASQVANDAVGSIRTVASFCAEEKVMEMYKKR-------CEDTIKSGIKQGLISGVG 891

  Fly   969 QAAPFL----AYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVN---DAIL 1026
            ....|.    .|....|.|..||...|.|:.|:.:|..||...:..:.||.::||:.:   .|.:
plant   892 FGISFFVLYSVYASCFYVGARLVKAGRTNFNDVFQVFLALTLTAVGISQASSFAPDSSKGKGAAV 956

  Fly  1027 SAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVA 1091
            |..|::|...:..::.....    .:|..:|||...::.|.|.||....:.:.|.|:|:...|||
plant   957 SIFRIIDRISKIDSRDESGM----VLENVKGDIELCHISFTYQTRPDVQVFRDLCLSIRAGQTVA 1017

  Fly  1092 LVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIA 1156
            |||.|||||||.:.||.|:|||.||.:.|.||...:..|..||.::|||.||||||:.||..|||
plant  1018 LVGESGSGKSTVISLLQRFYDPDSGHITLDGVELKKLRLKWLRQQMGLVGQEPVLFNDTIRANIA 1082

  Fly  1157 YGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTS-QLSGGQKQRIAIARALVRNPKI 1220
            ||.. .::.:..|||.|::.:|.|.|||::.:||||.:|:.. |||||||||:|||||:|:.|||
plant  1083 YGKG-GEEATEAEIIAASELANAHRFISSIQKGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKI 1146

  Fly  1221 LILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELM 1285
            |:|||||||||.|||:|||.|||.....||.:.:||||:|::|||:|.|:|.||:.|.|||:.|:
plant  1147 LLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVVKNGVIAEKGTHETLI 1211

  Fly  1286 AL-NKIYANL 1294
            .: ..:||:|
plant  1212 NIEGGVYASL 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	222/610 (36%)
		MdlB	720..1299	CDD:440747	222/587 (38%)
ABCB5	NP_192092.1	PTZ00265	2..1224	CDD:240339	465/1309 (36%)