DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB3

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_192091.1	Gene:	ABCB3 / 826951	AraportID:	AT4G01820	Length:	1229	Species:	Arabidopsis thaliana

Alignment Length:	1287	Identity:	468/1287 - (36%)
Similarity:	716/1287 - (55%)	Gaps:	85/1287 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 DATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAF 88
            :.|:...::.||.:|...:..|::|..:.|.......|...:::|:    |:|..
plant     3 EKTKTVPFYKLFSFSDSTDVLLMIVGSIGAIGNGVGFPLMTLLFGD----LIDSI---------- 53

  Fly    89 ALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRK 153
                   ||..:|....|....:.......|:|:|   .|.||.:...:....|    |..|||.
plant    54 -------GQNQSNKDIVEIVSKVCLKFVYLGLGTL---GAAFLQVACWMITGER----QAARIRS 104

  Fly   154 LFLEAMLRQDIAWYD--TSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGW 216
            |:|:.:|||||.::|  ||:| ....:|:.|...:.|.:|||:...:.||.|||.|.|.|||.||
plant   105 LYLKTILRQDIGFFDVETSTG-EVVGRMSGDTVLILEAMGEKVGKFIQLIATFVGGFVLAFVKGW 168

  Fly   217 KLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERF 281
            .||||:|..:|.:..|.:.:..:....:.:|..:|:.|:.|||:....||||.:|:|:::..:.:
plant   169 LLTLVMLVSIPLLAIAGAAMPIIVTRASSREQAAYAKASTVVEQTLGSIRTVASFTGEKQAMKSY 233

  Fly   282 GKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLF 346
            .:.:..|.....|:|...|:|..:.:.:.:...|||||:|..:||      .:.||...:|.|:.
plant   234 REFINLAYRASVKQGFSMGLGLGVVFFVFFCSYALAIWFGGEMIL------KKGYTGGEVVNVMV 292

  Fly   347 AVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRY 411
            .|:..:.:||..:|.:.|.|...||...:|..|:|...:|..|..|...|:..|.|....:.|.|
plant   293 TVVASSMSLGQTTPCLTAFAAGKAAAYKMFETIERKPSIDAFDLNGKVLEDIRGEIELRDVCFSY 357

  Fly   412 PARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWL 476
            ||||..|:..|.::.:..|.|.|.||.||.|||::|.|::|||||.:|||.:||.:|:...:.|:
plant   358 PARPMEEVFGGFSLLIPSGATAALVGESGSGKSSVISLIERFYDPSSGSVLIDGVNLKEFQLKWI 422

  Fly   477 RSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQI 541
            |.:||:|.||||||:::|.|||.||:.:||..:|:.||:.||..:||.:||:|.:|.|||.|.|:
plant   423 RGKIGLVSQEPVLFSSSIMENIGYGKENATVEEIQAAAKLANAANFIDKLPRGLETLVGEHGTQL 487

  Fly   542 SGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNAD 606
            |||||||||||||:::.|::|||||||||||..||:.||.||:......||::|||||||:.|||
plant   488 SGGQKQRIAIARAILKDPRILLLDEATSALDAESERVVQEALDRVMMSRTTVIVAHRLSTVRNAD 552

  Fly   607 KIVFLKDGVVAEQGTHEELM-ERRGLYCELVSITQRKEATEADEGA--VAGRPLQK--SQNLSDE 666
            .|..:..|.:.|:|:|.||: :..|.|.:|:.:.:.|:..:..|.:  :..|.:.:  |:|:...
plant   553 MIAVIHRGKIVEEGSHSELLKDHEGAYAQLIRLQKIKKEPKRLESSNELRDRSINRGSSRNIRTR 617

  Fly   667 ETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPE 731
            ..|||          .:...|.   .|.:.:|...|...|           .||.|::..||.||
plant   618 VHDDD----------SVSVLGL---LGRQENTEISREQSR-----------NVSITRIAALNKPE 658

  Fly   732 WRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQ 796
            ...:::|.:...::|..||::|:.|............|:.| :....|||||.:|:.:.:...:.
plant   659 TTILILGTLLGAVNGTIFPIFGILFAKVIEAFFKPPHDMKR-DSRFWSMIFVLLGVASLIVYPMH 722

  Fly   797 TYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQ 861
            ||:|..||.::..|:|...|..::..::.:|||..||.|.:.|||::|.:.::...|..:...::
plant   723 TYLFAVAGGRLIQRIRVMCFEKVVHMEVGWFDDPENSSGTIGSRLSADAALIKTLVGDSLSLSVK 787

  Fly   862 AVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITN 926
            ..|..|.|:::.|..||:..::.||.:||:.::.||:.:||......|||..|||||||.:|:.:
plant   788 NAAAAVSGLIIAFTASWKLAVIILVMIPLIGINGYLQIKFIKGFTADAKAKYEEASQVANDAVGS 852

  Fly   927 IRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRF---RGLVFALGQAAPFL----AYGISMYYGG 984
            ||||...|.|.:|::.|.::       |...::.   :||:..:|....|.    .|....|.|.
plant   853 IRTVASFCAEEKVMEMYKKR-------CEDTIKSGIKQGLISGVGFGISFFVLYSVYASCFYVGA 910

  Fly   985 ILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPY 1049
            .||...|.|:.|:.:|..||...:..:.||.::||:.:.|..:|..:..:....|...:..:|..
plant   911 RLVKAGRTNFNDVFQVFLALTMTAIGISQASSFAPDSSKAKGAAASIFGIIDGKSMIDSRDESGL 975

  Fly  1050 NTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPV 1114
             .:|..:|||...::.|.|.||....|.:.|...|:...||||||.|||||||.:.||.|:|||.
plant   976 -VLENVKGDIELCHISFTYQTRPDVQIFRDLCFAIRAGQTVALVGESGSGKSTVISLLQRFYDPD 1039

  Fly  1115 SGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNI 1179
            ||.:.|..|...:..|..:|.::|||.||||||:.||..|||||.. .|:.|..|||.||:.:|.
plant  1040 SGHITLDRVELKKLQLKWVRQQMGLVGQEPVLFNDTIRSNIAYGKG-GDEASEAEIIAAAELANA 1103

  Fly  1180 HNFISALPQGYDTRLGKTS-QLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALD 1243
            |.|||::.|||||.:|:.. |||||||||:|||||:|:.||||:|||||||||.|||:|||.|||
plant  1104 HGFISSIQQGYDTVVGERGIQLSGGQKQRVAIARAIVKEPKILLLDEATSALDAESERVVQDALD 1168

  Fly  1244 EARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMAL-NKIYANL 1294
            .....||.:.:||||:|::|||:|.|:|.||:||.|||:.|:.: ..:||:|
plant  1169 RVMVNRTTVVVAHRLSTIKNADVIAVVKNGVIVEKGTHETLINIEGGVYASL 1220

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	226/608 (37%)
		ABC_membrane	116..352	CDD:279056	77/237 (32%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	119/234 (51%)
		MdlB	735..1299	CDD:224055	221/569 (39%)
		ABC_membrane	739..998	CDD:279056	78/265 (29%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	128/238 (54%)
ABCB3	NP_192091.1	PTZ00265	4..1223	CDD:240339	468/1286 (36%)
		ABC_membrane	30..286	CDD:279056	83/290 (29%)
		ABC_MTABC3_MDL1_MDL2	348..586	CDD:213216	120/237 (51%)
		ABC_membrane	666..935	CDD:279056	81/276 (29%)
		ABC_MTABC3_MDL1_MDL2	984..1223	CDD:213216	128/238 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	162	1.000	Domainoid score	I1247
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840