DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB22

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001327523.1	Gene:	ABCB22 / 822471	AraportID:	AT3G28415	Length:	1229	Species:	Arabidopsis thaliana

Alignment Length:	1300	Identity:	435/1300 - (33%)
Similarity:	705/1300 - (54%)	Gaps:	117/1300 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQ 98
            :|.::...:..|:.:.|:.|.......|....|    |.||::   .:|.||       ||....
plant    10 IFMHANSVDLVLMGLGLIGAVGDGFITPIIFFI----TGLLLN---DIGDSS-------FGDKTF 60

  Fly    99 LTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLA---------NRIALNQIDRIRKL 154
            :         .||:.:|.|             ||......|.         .|....|..|:|:.
plant    61 M---------HAIMKNAVA-------------LLYVAGASLVICFVEGYCWTRTGERQASRMREK 103

  Fly   155 FLEAMLRQDIAWYD--TSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWK 217
            :|.|:||||:.::|  .:|.|:..:.::.|...:::.:.||:...:.....||...:..|:..|:
plant   104 YLRAVLRQDVGYFDLHVTSTSDVITSVSSDTLVIQDVLSEKLPNFLMSASAFVASYIVGFIMLWR 168

  Fly   218 LTLV-----VLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKE 277
            ||:|     :|..:|.::...:::     :::.|..:.|::|.::.|:..|.:|||:||..:.|.
plant   169 LTIVGFPFFILLLIPGLMCGRALI-----NISRKIREEYNEAGSIAEQAISLVRTVYAFGSERKM 228

  Fly   278 KERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPA--- 339
            ..:|...|..:...|.::|:..|:....:. :.|.......|||..:::         |..|
plant   229 ISKFSAALEGSVKLGLRQGIAKGIAIGSNG-VTYAIWGFMTWYGSRMVM---------YHGAKGG 283

  Fly   340 VLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRF 404
            .:..|:..:..|..:||....:::..:.|..||:.:..:|.|...:|..:.:|...||..|.::|
plant   284 TIFAVIICITYGGTSLGRGLSNLKYFSEAVVAGERIIEVIKRVPDIDSDNPRGQVLENIKGEVQF 348

  Fly   405 EGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLR 469
            :.::|.|.:||:..|...|.:.:..|::||.||.||.||||:|.|:||||||..|.:.:||..::
plant   349 KHVKFMYSSRPETPIFDDLCLRIPSGKSVALVGGSGSGKSTVISLLQRFYDPIVGEILIDGVSIK 413

  Fly   470 TLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQV 534
            .|.|.|||||:|:|.|||.||||:|.|||.:|:..|:..::.:||:::|.||||::.|.||.|||
plant   414 KLQVKWLRSQMGLVSQEPALFATSIEENILFGKEDASFDEVVEAAKSSNAHDFISQFPLGYKTQV 478

  Fly   535 GEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRL 599
            ||:|.|:||||||||:||||:::.|.:|||||||||||..||:.||.||:.|:.|.||:|:||||
plant   479 GERGVQMSGGQKQRISIARAIIKSPTLLLLDEATSALDSESERVVQEALDNATIGRTTIVIAHRL 543

  Fly   600 STITNADKIVFLKDGVVAEQGTHEELMER-RGLYCELVSITQRKEATEADEGAVAGRPLQKSQNL 663
            |||.|.|.|...|:|.:.|.|:||||||. .|.|..||    |.:..|.:|         .:.|:
plant   544 STIRNVDVICVFKNGQIVETGSHEELMENVDGQYTSLV----RLQIMENEE---------SNDNV 595

  Fly   664 SDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLN 728
            |....:....:..:|.:...:.|..||.|.|..|:.....:....|.|      |.||.:||.:|
plant   596 SVSMREGQFSNFNKDVKYSSRLSIQSRSSLFATSSIDTNLAGSIPKDK------KPSFKRLMAMN 654

  Fly   729 SPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGN 793
            .|||:..:.|.:::|::||..|::....|....:......|.::.:.....::|||:.::..|.:
plant   655 KPEWKHALYGCLSAVLYGALHPIYAYASGSMVSVYFLTSHDEMKEKTRIYVLLFVGLAVLCFLIS 719

  Fly   794 MLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGT 858
            ::|.|.|...|..:|.|:|:.....::..::::||::.||.|::|||||.|.:.|:...|.||..
plant   720 IIQQYSFAYMGEYLTKRIRENILSKLLTFEVSWFDEDENSSGSICSRLAKDANVVRSLVGERVSL 784

  Fly   859 MLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKS-AQKAKASIEEASQVAVE 922
            ::|.::.:.|...:|...||:.:::.:...|:|....|.: |.::|| ::||..:.:|:|::|.|
plant   785 LVQTISAVSVACTLGLAISWKLSIVMIAIQPVVVGCFYTQ-RIVLKSISKKAIKAQDESSKLAAE 848

  Fly   923 AITNIRTVNGLCLERQVLD--QYVQQIDRVDIACRRKVR---FRGLVFALGQAAPFLAYGISMYY 982
            |::||||:.....:.::|.  :.||:..:     |..:|   ..|:|.|..::.......::.:|
plant   849 AVSNIRTITAFSSQERILKLLKMVQEGPQ-----RENIRQSWLAGIVLATSRSLMTCTSALNYWY 908

  Fly   983 GGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNV---NDAILSAGRLMDLFKRTSTQPNP 1044
            |..|:.:.::..:...::....:....::..|.|...::   :||:.|...::|.:  |:.:|..
plant   909 GARLIIDGKITSKAFFELFILFVSTGRVIADAGAMTMDLAKGSDAVGSVFAVLDRY--TNIEPEK 971

  Fly  1045 PQS--PYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLL 1107
            |..  |.|.    :|.|.:.||.|.||||....|.:..::.|.:..:.|:||||||||||.:.|:
plant   972 PDGFVPQNI----KGQIKFVNVDFAYPTRPDVIIFKNFSIDIDEGKSTAIVGPSGSGKSTIIGLI 1032

  Fly  1108 LRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIE 1172
            .|:|||:.|.|.:.|.....:.|.:||..:|||||||:||..||.|||.|| ...|.:...||||
plant  1033 ERFYDPLKGIVKIDGRDIRSYHLRSLRQHIGLVSQEPILFAGTIRENIMYG-GASDKIDESEIIE 1096

  Fly  1173 AAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEK 1236
            |||.:|.|:||..|..||||..| :..|||||||||||||||:::||.:|:|||||||||.:||:
plant  1097 AAKAANAHDFIVTLSDGYDTYCGDRGVQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDNQSER 1161

  Fly  1237 VVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNK--IYANLYLMQQ 1299
            :||.||.....|||.:.|||||:|::|.|.|.||.:|.|||.|||..|:|...  :|.:|..:|:
plant  1162 MVQDALGRLMVGRTSVVIAHRLSTIQNCDTITVLDKGKVVECGTHSSLLAKGPTGVYFSLVSLQR 1226

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	209/625 (33%)
		ABC_membrane	116..352	CDD:279056	52/254 (20%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	125/234 (53%)
		MdlB	735..1299	CDD:224055	202/577 (35%)
		ABC_membrane	739..998	CDD:279056	65/264 (25%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	124/241 (51%)
ABCB22	NP_001327523.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I898
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840