Protein Alignment Mdr49 and ABCB17

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_189479.1
• Gene: ABCB17 / 822467
• AraportID: AT3G28380
• Length: 1240
• Species: Arabidopsis thaliana
• Alignment Length: 1323
• Identity: 445/1323 - (33%)
• Similarity: 719/1323 - (54%)
• Gaps: 140/1323 - (10%)

  Fly     1 MVKKEESRLPQAGDFQLKE-GSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFM 64
            |.|::|.   ::|..::|. ||:         ..:|.::...:..|:.:.|:.|.......|..:
plant     1 MGKEDEK---ESGRDKMKSFGSI---------RSIFMHADGVDWILMALGLIGAVGDGFITPVVV 53

  Fly    65 IIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAM 129
            .|   |.:||.:    :||||                    .||:..:...:...:..|..:...
plant    54 FI---FNTLLNN----LGTSS--------------------SNNKTFMQTISKNVVALLYVACGS 91

  Fly   130 FLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYD--TSSGSNFASKMTEDLDKLKEGIGE 192
            :::..|......|....|..|:|:.:|.|:||||:.::|  .:|.|:..:.::.|...:::.:.|
plant    92 WVICFLEGYCWTRTGERQAARMREKYLRAVLRQDVGYFDLHVTSTSDVITSISSDSLVIQDFLSE 156

  Fly   193 KIVIVVFLIMTFVIGIVSAFVYGWKLTLV-----VLSCVPFIIAATSVVARLQGSLAEKELKSYS 252
            |:...:.....||...:.:|:..|:||:|     :|..||.::...::|     |::.|..:.|:
plant   157 KLPNFLMNASAFVASYIVSFILMWRLTIVGFPFIILLLVPGLMYGRALV-----SISRKIHEQYN 216

  Fly   253 DAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGM---GNALSWLIIYLCM 314
            :|.::.|:..|.:|||:||..:.|...:|...|..:...|.::||..|:   .|.::..|    .
plant   217 EAGSIAEQAISSVRTVYAFGSENKMIGKFSTALRGSVKLGLRQGLAKGITIGSNGVTHAI----W 277

  Fly   315 ALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNII 379
            |...|||..|:::.......|:      :|:..:..|..:||.:..:::..:.|..|.:.:..:|
plant   278 AFLTWYGSRLVMNHGSKGGTVF------VVISCITYGGVSLGQSLSNLKYFSEAFVAWERILEVI 336

  Fly   380 DRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKS 444
            .|...:|...::|...|...|.:.|..::|.|.:||:..|...|.:.:..|:|||.||.||.|||
plant   337 KRVPDIDSNKKEGQILERMKGEVEFNHVKFTYLSRPETTIFDDLCLKIPAGKTVALVGGSGSGKS 401

  Fly   445 TLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQAD 509
            |:|.|:||||||.||.:.:||..:..|.|.|||||:|:|.||||||||:|.|||.:|:..|:..:
plant   402 TVISLLQRFYDPIAGEILIDGVSIDKLQVNWLRSQMGLVSQEPVLFATSITENILFGKEDASLDE 466

  Fly   510 IEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPT 574
            :.:||:|:|.|.||::.|.||.|||||:|.|:|||||||||||||:::.|::|||||||||||..
plant   467 VVEAAKASNAHTFISQFPLGYKTQVGERGVQMSGGQKQRIAIARAIIKSPKILLLDEATSALDSE 531

  Fly   575 SEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMER-RGLYCELVSI 638
            ||:.||.:|:.||.|.||:|:|||||||.|||.|..:.:|.:.|.|:||||::| .|.|..|||:
plant   532 SERVVQESLDNASIGRTTIVIAHRLSTIRNADVICVIHNGQIVETGSHEELLKRIDGQYTSLVSL 596

  Fly   639 TQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRR 703
            .|    .|.:|..|         |::...|.|             |....|:|  |:.|......
plant   597 QQ----MENEESNV---------NINVSVTKD-------------QVMSLSKD--FKYSQHNSIG 633

  Fly   704 SQRRKKKKDKEVVSKV-------------SFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLF 755
            |      ....:|:.|             |||:||.:|.|||:..:.|.:::.:.|...|:....
plant   634 S------TSSSIVTNVSDLIPNDNQPLVPSFTRLMVMNRPEWKHALYGCLSAALVGVLQPVSAYS 692

  Fly   756 FGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTII 820
            .|....:......|.::.:.....::|||:.:.:.|.|:.|.|.|...|..:|.|:|::....|:
plant   693 AGSVISVFFLTSHDQIKEKTRIYVLLFVGLAIFSFLVNISQHYGFAYMGEYLTKRIREQMLSKIL 757

  Fly   821 GQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTL 885
            ..::.:||.:.||.||:|||||.|.:.|:...|.|:..::|.::.:::..::|.|.:|:..::.:
plant   758 TFEVNWFDIDDNSSGAICSRLAKDANVVRSMVGDRMSLLVQTISAVIIACIIGLVIAWRLAIVMI 822

  Fly   886 VTLPLVCLSVYLEGRFIMKS-AQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDR 949
            ...||:.:..|.: |.::|| ::||..:.:|:|::|.||::||||:.....:.::    ::.:.:
plant   823 SVQPLIVVCFYTQ-RVLLKSLSEKASKAQDESSKLAAEAVSNIRTITAFSSQERI----IKLLKK 882

  Fly   950 VDIACRRKVRFR----GLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWM 1010
            |....||:...|    |:|....::.......::.:|||.|:|:.::..:...::  .|||.:
plant   883 VQEGPRRESVHRSWLAGIVLGTSRSLITCTSALNFWYGGRLIADGKIVSKAFFEI--FLIFVT-- 943

  Fly  1011 LGQALAYAPNVN-------DAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEY 1068
            .|:.:|.|..:.       ||:.|...::|  :.|:.:|..|..  ...||.:|.|.:.||.|.|
plant   944 TGRVIADAGTMTTDLARGLDAVGSVFAVLD--RCTTIEPKNPDG--YVAEKIKGQITFLNVDFAY 1004

  Fly  1069 PTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTL 1133
            |||....|.:..::.|.:..:.|:||.|||||||.:.|:.|:|||:.|:|.:.|.....:.|.:|
plant  1005 PTRPDVVIFENFSIEIDEGKSTAIVGTSGSGKSTIIGLIERFYDPLKGTVKIDGRDIRSYHLRSL 1069

  Fly  1134 RSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KT 1197
            |..:.||||||:||..||.|||.||.. .|.:...|||||||.:|.|:||::|..||||..| |.
plant  1070 RKYISLVSQEPMLFAGTIRENIMYGGT-SDKIDESEIIEAAKAANAHDFITSLSNGYDTNCGDKG 1133

  Fly  1198 SQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVR 1262
            .|||||||||||||||:::||.:|:|||||||||.:||:|||.||:....|||.:.|||||:|::
plant  1134 VQLSGGQKQRIAIARAVLKNPSVLLLDEATSALDSKSERVVQDALERVMVGRTSIMIAHRLSTIQ 1198

  Fly  1263 NADLICVLKRGVVVEHGTHDELM 1285
            |.|:|.||.:|.:||.|||..|:
plant  1199 NCDMIVVLGKGKIVESGTHSSLL 1221

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	213/609 (35%)
		MdlB	720..1299	CDD:440747	210/579 (36%)
ABCB17	NP_189479.1	MdlB	32..600	CDD:440747	213/613 (35%)
		MdlB	657..1236	CDD:440747	210/579 (36%)