DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB16

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_189477.4	Gene:	ABCB16 / 822465	AraportID:	AT3G28360	Length:	1228	Species:	Arabidopsis thaliana

Alignment Length:	1267	Identity:	431/1267 - (34%)
Similarity:	685/1267 - (54%)	Gaps:	119/1267 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    79 VGVGTSSP------AFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAI 137
            ||.|..:|      |..|..||        |...|::..:...:...:..|..:.|.:::..|..
plant    30 VGDGFITPILFFITAMLLNDFG--------SFSFNDETFMQPISKNALAMLYVACASWVICFLEG 86

  Fly   138 DLANRIALNQIDRIRKLFLEAMLRQDIAWYD--TSSGSNFASKMTEDLDKLKEGIGEKIVIVVFL 200
            ....|....|..::|:.:|.|:||||:.::|  .:|.|:..:.::.|...:::.:.||:..::..
plant    87 YCWTRTGERQAAKMRERYLRAVLRQDVGYFDLHVTSTSDIITSVSSDSLVIQDFLSEKLPNILMN 151

  Fly   201 IMTFVIGIVSAFVYGWKLTLV-----VLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEE 260
            ...||...:..|:..|:||:|     :|..:|.::...:::     .::.|..:.|::|.::.|:
plant   152 ASAFVGSYIVGFMLLWRLTIVGFPFIILLLIPGLMYGRALI-----GISRKIREEYNEAGSIAEQ 211

  Fly   261 VFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLI 325
            ..|.:|||:||..::|..|:|...|..:...|.::||..|:....:. |:|.......|||..::
plant   212 AISSVRTVYAFVSEKKMIEKFSDALQGSVKLGLRQGLAKGIAIGSNG-IVYAIWGFLTWYGSRMV 275

  Fly   326 LDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDE 390
            ::..      |....:..|...|..|...||.|..:::..:.|..||:.:..:|.|...:|..:.
plant   276 MNYG------YKGGTVSTVTVCVTFGGTALGQALSNLKYFSEAFVAGERIQKMIKRVPDIDSDNL 334

  Fly   391 KGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYD 455
            .|:..|...|.:.|..::.:||:||:..|...|.:.:..|:|||.||.||.||||:|.|:|||||
plant   335 NGHILETIRGEVEFNNVKCKYPSRPETLIFDDLCLKIPSGKTVALVGGSGSGKSTVISLLQRFYD 399

  Fly   456 PEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCH 520
            |..|.:.:|...:..:.|.|||||:|:|.|||.||||:|.|||.:|:..|:..::.:||:|:|.|
plant   400 PNEGDILIDSVSINNMQVKWLRSQMGMVSQEPSLFATSIKENILFGKEDASFDEVVEAAKASNAH 464

  Fly   521 DFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALEL 585
            :||::.|.||.|||||:|..:||||||||||||||::.|.:|||||||||||..||:.||.||:.
plant   465 NFISQFPHGYQTQVGERGVHMSGGQKQRIAIARALIKSPIILLLDEATSALDLESERVVQEALDN 529

  Fly   586 ASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEAD-- 648
            ||.|.||:|:|||||||.|||.|..|.:|.:.|.|:|::|||..|.|..||.:.|.|.....|
plant   530 ASVGRTTIVIAHRLSTIRNADIICVLHNGCIVETGSHDKLMEIDGKYTSLVRLQQMKNEESCDNT 594

  Fly   649 -----EGAVAG-------RPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRK 701
                 ||.|:.       .|...:.::|.....:..:...:|::|.:.
plant   595 SVGVKEGRVSSLRNDLDYNPRDLAHSMSSSIVTNLSDSIPQDKKPLVP----------------- 642

  Fly   702 RRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLW----GLFFGDFFGI 762
                              ||.:||.:|.|||:..:.|.:::.:.||..|::    ||....||..
plant   643 ------------------SFKRLMAMNRPEWKHALCGCLSASLGGAVQPIYAYSSGLMISVFFLT 689

  Fly   763 LSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYF 827
            ..:...:..|..||    :|.|:.|.....::.|.|.|:..|..:|.|:|::....|:..::.:|
plant   690 NHEQIKENTRIYVL----LFFGLALFTFFTSISQQYSFSYMGEYLTKRIREQMLSKILTFEVNWF 750

  Fly   828 DDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVC 892
            |:|.||.||:|||||.|.:.|:...|.|:..::|.::|::|...:|.|.:|:.|::.:...|::.
plant   751 DEEENSSGAICSRLAKDANVVRSLVGERMSLLVQTISTVMVACTIGLVIAWRFTIVMISVQPVII 815

  Fly   893 LSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLD--QYVQQIDRVDIACR 955
            :..|::...:...::||..:.:|:|::|.||::||||:.....:.:::.  :.||:..|.:.|
plant   816 VCYYIQRVLLKNMSKKAIIAQDESSKLAAEAVSNIRTITTFSSQERIMKLLERVQEGPRRESA-- 878

  Fly   956 RKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEA-----LIFGSWMLGQAL 1015
            |:....|::....|:.......::.:|||.|:|:.:|       |::|     |||.:  .|:|:
plant   879 RQSWLAGIMLGTTQSLITCTSALNFWYGGKLIADGKM-------VSKAFFELFLIFKT--TGRAI 934

  Fly  1016 AYAPNVNDAILSAGRLMD-----LFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTP 1075
            |.|..:...:......:|     |.:||:.:|..|..  ..:||.:|.|.:.||.|.||||....
plant   935 AEAGTMTTDLAKGSNSVDSVFTVLDRRTTIEPENPDG--YILEKIKGQITFLNVDFAYPTRPNMV 997

  Fly  1076 ILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLV 1140
            |....::.|.:..:.|:||||.|||||.:.|:.|:|||:.|.|.:.|.....:.|.:||..:.||
plant   998 IFNNFSIEIHEGKSTAIVGPSRSGKSTVIGLIERFYDPLQGIVKIDGRDIRSYHLRSLRQHMSLV 1062

  Fly  1141 SQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQ 1204
            ||||.||..||.|||.|| ...:.:...|||||.|.:|.|.||::|..||||..| :..||||||
plant  1063 SQEPTLFAGTIRENIMYG-RASNKIDESEIIEAGKTANAHEFITSLSDGYDTYCGDRGVQLSGGQ 1126

  Fly  1205 KQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICV 1269
            ||||||||.:::||.||:|||||||||.:||:|||.||:....|:|.:.|||||:|::|.|.|.|
plant  1127 KQRIAIARTILKNPSILLLDEATSALDSQSERVVQDALEHVMVGKTSVVIAHRLSTIQNCDTIAV 1191

  Fly  1270 LKRGVVVEHGTHDELMALNKI--YANLYLMQQ 1299
            |.:|.|||.|||..|:|....  |.:|..:|:
plant  1192 LDKGKVVESGTHASLLAKGPTGSYFSLVSLQR 1223

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	203/573 (35%)
		ABC_membrane	116..352	CDD:279056	53/242 (22%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	125/233 (54%)
		MdlB	735..1299	CDD:224055	209/582 (36%)
		ABC_membrane	739..998	CDD:279056	70/264 (27%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	120/241 (50%)
ABCB16	NP_189477.4	PTZ00265	21..1208	CDD:240339	427/1250 (34%)
		ABC_membrane	26..277	CDD:279056	60/260 (23%)
		ABC_MTABC3_MDL1_MDL2	346..583	CDD:213216	127/236 (54%)
		ABC_membrane	662..927	CDD:279056	73/277 (26%)
		ABC_MTABC3_MDL1_MDL2	981..1222	CDD:213216	120/241 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I898
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.790