DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB15

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_189475.1	Gene:	ABCB15 / 822463	AraportID:	AT3G28345	Length:	1240	Species:	Arabidopsis thaliana

Alignment Length:	1262	Identity:	444/1262 - (35%)
Similarity:	700/1262 - (55%)	Gaps:	101/1262 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 VGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLAN---- 141
            :|.....|..|:.     |...||..||..    .::|...:.:.|::...:..|.:...:
plant    40 IGAVGDGFTTPLV-----LLITSKLMNNIG----GSSFNTDTFMQSISKNSVALLYVACGSWVVC 95

  Fly   142 --------RIALNQIDRIRKLFLEAMLRQDIAWYD--TSSGSNFASKMTEDLDKLKEGIGEKIVI 196
                    |....|..|:|:.:|.|:||||:.::|  .:|.|:..:.::.|...:::.:.||:..
plant    96 FLEGYCWTRTGERQTARMREKYLRAVLRQDVGYFDLHVTSTSDVITSVSSDSFVIQDVLSEKLPN 160

  Fly   197 VVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEV 261
            .:....|||...:..|:..|:|.:|.|..:..::....:..|...|::.|..:.|::|..|.|:.
plant   161 FLMSASTFVGSYIVGFILLWRLAIVGLPFIVLLVIPGLMYGRALISISRKIREEYNEAGFVAEQA 225

  Fly   262 FSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGM---GNALSWLIIYLCMALAIWYGVT 323
            .|.:|||:||||:.|...:|...|..:...|.|:||..|:   .|.    |.:.......|||..
plant   226 ISSVRTVYAFSGERKTISKFSTALQGSVKLGIKQGLAKGITIGSNG----ITFAMWGFMSWYGSR 286

  Fly   324 LILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPM 388
            :::........|:..|.      |:.:|..:||....:::....|.:.|:.:..:|:|..::|..
plant   287 MVMYHGAQGGTVFAVAA------AIAIGGVSLGGGLSNLKYFFEAASVGERIMEVINRVPKIDSD 345

  Fly   389 DEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRF 453
            :..|::.|...|.:.|:.::|.||:|.:..|.....:.|..|:|||.||.||.||||:|.|:|||
plant   346 NPDGHKLEKIRGEVEFKNVKFVYPSRLETSIFDDFCLRVPSGKTVALVGGSGSGKSTVISLLQRF 410

  Fly   454 YDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAAN 518
            |||.||.:.:||..:..|.|.|||||:|:|.|||.||||||.|||.:|:..|:..|:.:||:|:|
plant   411 YDPLAGEILIDGVSIDKLQVKWLRSQMGLVSQEPALFATTIKENILFGKEDASMDDVVEAAKASN 475

  Fly   519 CHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSAL 583
            .|:||::||.||:|||||:|.|:|||||||||||||:::.|.:|||||||||||..||:.||.||
plant   476 AHNFISQLPNGYETQVGERGVQMSGGQKQRIAIARAIIKSPTILLLDEATSALDSESERVVQEAL 540

  Fly   584 ELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMER-RGLYCELVSITQRKEATEA 647
            |.||.|.||:::|||||||.|||.|..:|:|.:.|.|:|:||||. .|.|..||.: |:.|..:.
plant   541 ENASIGRTTILIAHRLSTIRNADVISVVKNGHIVETGSHDELMENIDGQYSTLVHL-QQIEKQDI 604

  Fly   648 DEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRAST---RRKRRSQRRKK 709
            :.....| |:               .|..:|.....:.|..||.|...:.|   ..|..|:..|.
plant   605 NVSVKIG-PI---------------SDPSKDIRNSSRVSTLSRSSSANSVTGPSTIKNLSEDNKP 653

  Fly   710 KKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAE 774
            :..       ||.:|:.:|.|||:..:.|.|::.:.||..|.:....|....:......|.::.:
plant   654 QLP-------SFKRLLAMNLPEWKQALYGCISATLFGAIQPAYAYSLGSMVSVYFLTSHDEIKEK 711

  Fly   775 VLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCS 839
            ....::.|||:.:::.|.|:.|.|.|...|..:|.|:|:|....::..::.:||.:.||.||:||
plant   712 TRIYALSFVGLAVLSFLINISQHYNFAYMGEYLTKRIRERMLSKVLTFEVGWFDRDENSSGAICS 776

  Fly   840 RLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMK 904
            |||.|.:.|:...|.|:..::|.|:.:.:...:|.|.:|:..|:.:...|::.:..|.. |.::|
plant   777 RLAKDANVVRSLVGDRMALVVQTVSAVTIAFTMGLVIAWRLALVMIAVQPVIIVCFYTR-RVLLK 840

  Fly   905 S-AQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRK-VR---FRGLV 964
            | ::||..:.:|:|::|.||::|:||:.....:.:::    :.:::...:.||: :|   |.|..
plant   841 SMSKKAIKAQDESSKLAAEAVSNVRTITAFSSQERIM----KMLEKAQESPRRESIRQSWFAGFG 901

  Fly   965 FALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWML----GQALAYAPNV---- 1021
            .|:.|:.....:.:..:|||.|:       :|....|:|| |.::|:    |:.:|.|.::
plant   902 LAMSQSLTSCTWALDFWYGGRLI-------QDGYITAKAL-FETFMILVSTGRVIADAGSMTTDL 958

  Fly  1022 ---NDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLT 1083
               :||:.|...::|.:  ||..|..|.. |.| |:..|.:.:.:|.|.||||....|.:..::.
plant   959 AKGSDAVGSVFAVLDRY--TSIDPEDPDG-YET-ERITGQVEFLDVDFSYPTRPDVIIFKNFSIK 1019

  Fly  1084 IKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFD 1148
            |::..:.|:||||||||||.:.|:.|:|||:.|.|.:.|.....:.|.:||..:.||||||.||.
plant  1020 IEEGKSTAIVGPSGSGKSTIIGLIERFYDPLKGIVKIDGRDIRSYHLRSLRRHIALVSQEPTLFA 1084

  Fly  1149 RTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIAR 1212
            .||.|||.|| ...|.:...|||||||.:|.|:||::|.:||||..| :..||||||||||||||
plant  1085 GTIRENIIYG-GVSDKIDEAEIIEAAKAANAHDFITSLTEGYDTYCGDRGVQLSGGQKQRIAIAR 1148

  Fly  1213 ALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVE 1277
            |:::||.:|:|||||||||.:||:|||.||:....|||.:.|||||:|::|.|.|.||.:|.:||
plant  1149 AVLKNPSVLLLDEATSALDSQSERVVQDALERVMVGRTSVVIAHRLSTIQNCDAIAVLDKGKLVE 1213

  Fly  1278 HGTHDELMALNK--IYANLYLMQQVSG 1302
            .|||..|::...  ||.:|..:|..||
plant  1214 RGTHSSLLSKGPTGIYFSLVSLQTTSG 1240

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	211/576 (37%)
		ABC_membrane	116..352	CDD:279056	58/252 (23%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	132/234 (56%)
		MdlB	735..1299	CDD:224055	209/582 (36%)
		ABC_membrane	739..998	CDD:279056	67/263 (25%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	121/241 (50%)
ABCB15	NP_189475.1	PTZ00265	34..1235	CDD:240339	441/1255 (35%)
		ABC_membrane	39..299	CDD:279056	63/271 (23%)
		ABC_MTABC3_MDL1_MDL2	359..597	CDD:213216	134/238 (56%)
		ABC_membrane	676..935	CDD:279056	70/271 (26%)
		ABC_MTABC3_MDL1_MDL2	995..1236	CDD:213216	121/241 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I898
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.840