DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Mdr49 and ABCB4

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_001323911.1 Gene:ABCB4 / 819314 AraportID:AT2G47000 Length:1286 Species:Arabidopsis thaliana


Alignment Length:1325 Identity:475/1325 - (35%)
Similarity:747/1325 - (56%) Gaps:104/1325 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KKEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIY 67
            |:||..:.:..    |:....:.|:...::.||.::...:..|:::..|.:.......|...:::
plant    24 KEEEEEVKKTE----KKDEEHEKTKTVPFYKLFAFADSFDFLLMILGTLGSIGNGLGFPLMTLLF 84

  Fly    68 GEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLL 132
            |:    |:|          ||       |:..||.:.:.:..|:  .....|||:.   .|.||.
plant    85 GD----LID----------AF-------GENQTNTTDKVSKVAL--KFVWLGIGTF---AAAFLQ 123

  Fly   133 ITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWY--DTSSGSNFASKMTEDLDKLKEGIGEKIV 195
            ::..:....|    |..|||.|:|:.:||||||::  ||::| ....:|:.|...:::.:|||:.
plant   124 LSGWMISGER----QAARIRSLYLKTILRQDIAFFDIDTNTG-EVVGRMSGDTVLIQDAMGEKVG 183

  Fly   196 IVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEE 260
            ..:.|:.|||.|.|.|||.||.||||:||.:|.::.|.:::|.:....|.:...:|:.||.|||:
plant   184 KAIQLLATFVGGFVIAFVRGWLLTLVMLSSIPLLVMAGALLAIVIAKTASRGQTAYAKAATVVEQ 248

  Fly   261 VFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLI 325
            ....||||.:|:|:::....:.|.|:.|...|..:|..:|:|....:|:::...|||:|||..||
plant   249 TIGSIRTVASFTGEKQAISNYNKHLVTAYKAGVIEGGSTGLGLGTLFLVVFCSYALAVWYGGKLI 313

  Fly   326 LDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDE 390
            |      |:.||...::.::.||:.|:.:||..||.:.|.|...||...:|..|:|...:|....
plant   314 L------DKGYTGGQVLNIIIAVLTGSMSLGQTSPCLSAFAAGQAAAYKMFETIERRPNIDSYST 372

  Fly   391 KGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYD 455
            .|...::..|.|..:.:.|.||||||.:|.:|.::.:..|.|||.||.||.||||::.|::||||
plant   373 NGKVLDDIKGDIELKDVYFTYPARPDEQIFRGFSLFISSGTTVALVGQSGSGKSTVVSLIERFYD 437

  Fly   456 PEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCH 520
            |:||.|.:||.:|:...:.|:||:||:|.||||||..:|.:||.||:..||..:|:.||..||..
plant   438 PQAGDVLIDGINLKEFQLKWIRSKIGLVSQEPVLFTASIKDNIAYGKEDATTEEIKAAAELANAS 502

  Fly   521 DFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALEL 585
            .|:.:||:|.||.|||.|.|:|||||||||:|||:::.|::|||||||||||..||:.||.||:.
plant   503 KFVDKLPQGLDTMVGEHGTQLSGGQKQRIAVARAILKDPRILLLDEATSALDAESERVVQEALDR 567

  Fly   586 ASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELM-ERRGLYCELVSITQRKEATEADE 649
            .....||:||||||||:.|||.|..:..|.:.|:|:|.||: :..|.|.:|:.:.:.|   ::||
plant   568 IMVNRTTVVVAHRLSTVRNADMIAVIHQGKIVEKGSHTELLKDPEGAYSQLIRLQEEK---KSDE 629

  Fly   650 GAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRAS--------------TRR 700
            .|.      :.|.:|..|:.......:......|...||||.:..|.|              .:.
plant   630 NAA------EEQKMSSIESFKQSSLRKSSLGRSLSKGGSSRGNSSRHSFNMFGFPAGIDGNVVQD 688

  Fly   701 KRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSD 765
            :......:.|.:.:   |||..::..||.||...:::|.|::..:|...|::|:..         
plant   689 QEEDDTTQPKTEPK---KVSIFRIAALNKPEIPVLILGSISAAANGVILPIFGILI--------- 741

  Fly   766 GDDDVVRA-----EVLK-----ISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTII 820
              ..|::|     :.||     .::||:.:|..:.:....||:.|..||.|:..|:|...|..::
plant   742 --SSVIKAFFQPPKKLKEDTSFWAIIFMVLGFASIIAYPAQTFFFAIAGCKLVQRIRSMCFEKVV 804

  Fly   821 GQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTL 885
            ..::.:||:..||.|.:.:||::|.:.::|..|..:...:|.:::::.|:::.|:..||...:.|
plant   805 HMEVGWFDEPENSSGTIGARLSADAATIRGLVGDSLAQTVQNLSSILAGLIIAFLACWQLAFVVL 869

  Fly   886 VTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRV 950
            ..|||:.|:.:|..:|:...:..||....||||||.:|:.:||||...|.|.:|::.|.::.:. 
plant   870 AMLPLIALNGFLYMKFMKGFSADAKKMYGEASQVANDAVGSIRTVASFCAEDKVMNMYSKKCEG- 933

  Fly   951 DIACRRKVRFRGLVFALGQAAPFL----AYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWML 1011
              ..:..:| :|:|..:|....|.    :|..|.|.|..||.:.:..::.:.:|..||...:..:
plant   934 --PMKNGIR-QGIVSGIGFGFSFFVLFSSYAASFYVGARLVDDGKTTFDSVFRVFFALTMAAMAI 995

  Fly  1012 GQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPI 1076
            .|:.:.:|:.:.|.::|..:..:..|.| :.:|.......::..:|||...:|.|:||.|....|
plant   996 SQSSSLSPDSSKADVAAASIFAIMDRES-KIDPSVESGRVLDNVKGDIELRHVSFKYPARPDVQI 1059

  Fly  1077 LQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVS 1141
            .|.|.|:|:...||||||.|||||||.:.||.|:|||.||.:.|.||......|..||.:.||||
plant  1060 FQDLCLSIRAGKTVALVGESGSGKSTVIALLQRFYDPDSGEITLDGVEIKSLRLKWLRQQTGLVS 1124

  Fly  1142 QEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKTS-QLSGGQK 1205
            |||:||:.||..|||||..  .|.|..||:.:|:.||.|.|||.|.|||||.:|:.. |||||||
plant  1125 QEPILFNETIRANIAYGKG--GDASESEIVSSAELSNAHGFISGLQQGYDTMVGERGIQLSGGQK 1187

  Fly  1206 QRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVL 1270
            ||:|||||:|::||:|:|||||||||.|||:|||.|||.....||.:.:||||:|::|||:|.|:
plant  1188 QRVAIARAIVKDPKVLLLDEATSALDAESERVVQDALDRVMVNRTTIVVAHRLSTIKNADVIAVV 1252

  Fly  1271 KRGVVVEHGTHDELMAL-NKIYANL 1294
            |.||:||.|.||.|:.: :.:||:|
plant  1253 KNGVIVEKGKHDTLINIKDGVYASL 1277

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 233/608 (38%)
ABC_membrane 116..352 CDD:279056 82/237 (35%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 121/234 (52%)
MdlB 735..1299 CDD:224055 215/576 (37%)
ABC_membrane 739..998 CDD:279056 70/272 (26%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 132/238 (55%)
ABCB4NP_001323911.1 PTZ00265 46..1280 CDD:240339 470/1299 (36%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 1 1.000 162 1.000 Domainoid score I1247
eggNOG 1 0.900 - - E2759_KOG0055
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 876 1.000 Inparanoid score I60
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - mtm951
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - O PTHR24221
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X92
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.840

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