Protein Alignment Mdr49 and ABCB6

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_181480.1
• Gene: ABCB6 / 818533
• AraportID: AT2G39480
• Length: 1407
• Species: Arabidopsis thaliana
• Alignment Length: 1248
• Identity: 405/1248 - (32%)
• Similarity: 636/1248 - (50%)
• Gaps: 127/1248 - (10%)

  Fly   151 IRKLFLEAMLRQDIAWYDT-SSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVY 214
            ||..:::.:|.||::::|| .:..:..|::..|:..::..:.||:...:..:.||:.|::..||.
plant   168 IRSKYVQVLLNQDMSFFDTYGNNGDIVSQVLSDVLLIQSALSEKVGNYIHNMATFISGLIIGFVN 232

  Fly   215 GWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKE 279
            .|::.|:.|:..|||:||..:.......|||....:|::||::.|:..|.:||::||:.:...|.
plant   233 CWEIALITLATGPFIVAAGGISNIFLHRLAENIQDAYAEAASIAEQAVSYVRTLYAFTNETLAKY 297

  Fly   280 RFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIV 344
            .:...|......|....|..|:|...::.:.....|:.:|.|...::..|.....:.|      .
plant   298 SYATSLQATLRYGILISLVQGLGLGFTYGLAICSCAMQLWIGRFFVIHHRANGGEIIT------A 356

  Fly   345 LFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRF 409
            |||||:....|..|:.:..:......|...||.:|.|.|  ...:::|.......|:|.|..:.|
plant   357 LFAVILSGLGLNQAATNFYSFDQGRIAAYRLFEMISRSS--SGTNQEGIILSAVQGNIEFRNVYF 419

  Fly   410 RYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVG 474
            .|.:||::.||.|..:.|...:.||.||.:|.|||::|.||:|||||..|.|.|||.:::.|.:.
plant   420 SYLSRPEIPILSGFYLTVPAKKAVALVGRNGSGKSSIIPLMERFYDPTLGEVLLDGENIKNLKLE 484

  Fly   475 WLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGA 539
            |||||||:|.|||.|.:.:|.|||.||| .||...||:||:.|:.|.||:.|.|||:||||:.|.
plant   485 WLRSQIGLVTQEPALLSLSIRENIAYGR-DATLDQIEEAAKKAHAHTFISSLEKGYETQVGKTGL 548

  Fly   540 QISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITN 604
            .::..||.:::||||::..|.:|||||.|..||..:|:.||.||:|...|.:|:::|.|||.|.|
plant   549 TLTEEQKIKLSIARAVLLDPTILLLDEVTGGLDFEAERVVQEALDLLMLGRSTIIIARRLSLIRN 613

  Fly   605 ADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEAT-----------------EADEGAV 652
            ||.|..:::|.:.|.|||:||:....||.||:..   :|||                 :|:..:.
plant   614 ADYIAVMEEGQLLEMGTHDELINLGNLYAELLKC---EEATKLPRRMPVRNYNDSAAFQAERDSS 675

  Fly   653 AGR--------------PLQKSQNL-SDEETDDDEEDEEEDEEP---ELQTSGSSRDSGFRASTR 699
            |||              .||:..|: ..:|...:.|:...|..|   :|..:|||.|.|.:..|.
plant   676 AGRGFQEPSSPKMAKSPSLQRGHNVFRSQELCFNSEESPNDHSPAPEKLGENGSSLDVGEKEPTI 740

  Fly   700 RKRRS----------------QRRKKK-------------------------------------- 710
            :::.|                ||:|..
plant   741 KRQDSFEMRLPELPKIDIQCPQRQKSNGSDPESPISPLLISDPQNERSHSQTFSRPLGHSDDTSA 805

  Fly   711 -----KDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDV 770
                 ||.:.....||.:|.:|:.|||.:.|:|.|.:.:.|:..||...................
plant   806 SVKVAKDGQHKEPPSFWRLAQLSFPEWLYAVLGSIGAAIFGSFNPLLAYVIALVVTTYYTSKGSH 870

  Fly   771 VRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVG 835
            :|.||.|..:|...:|::..:.|.||.:.|...|.|||.|:|:..|..::..::.::|:|.||..
plant   871 LREEVDKWCLIIACMGIVTVVANFLQHFYFGIMGEKMTERVRRMMFSAMLRNEVGWYDEEENSPD 935

  Fly   836 ALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGR 900
            .|..|||:|.:.|:.|...|:...:|....::|.:::|.:..|:..|:.|.|||::.||...:..
plant   936 TLSMRLANDATFVRAAFSNRLSIFIQDSFAVIVAILIGLLLGWRLALVALATLPVLTLSAIAQKL 1000

  Fly   901 FIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLV- 964
            ::...::..:....:||.|..:|:.||.||...|...:|::.|..|:.|:    .|:..|.|:.
plant  1001 WLAGFSKGIQEMHRKASLVLEDAVRNIYTVVAFCAGNKVMELYRLQLQRI----LRQSFFHGMAI 1061

  Fly   965 -FALG--QAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAIL 1026
             ||.|  |...|....:.::|..:.|....|.....:.......|.::.|.:....||.:.....
plant  1062 GFAFGFSQFLLFACNALLLWYTALSVDRRYMKLSTALTEYMVFSFATFALVEPFGLAPYILKRRR 1126

  Fly  1027 SAGRLMDLFKRTST-QPNPPQ--SPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKST 1088
            |...:.::..|..| :|:...  ||.|..    |.|..:|:.|.||||....:|...:|.:....
plant  1127 SLASVFEIIDRVPTIEPDDTSALSPPNVY----GSIELKNIDFCYPTRPEVLVLSNFSLKVNGGQ 1187

  Fly  1089 TVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAE 1153
            |||:||.|||||||.:.|:.||||||:|.|.|.|.....:.|..|||.:||:.|||::|..||.|
plant  1188 TVAVVGVSGSGKSTIISLIERYYDPVAGQVLLDGRDLKSYNLRWLRSHMGLIQQEPIIFSTTIRE 1252

  Fly  1154 NIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRN 1217
            ||.|.   |.:.|..|:.|||:.:|.|:|||:||.||||.:| :..:|:.||||||||||.:::|
plant  1253 NIIYA---RHNASEAEMKEAARIANAHHFISSLPHGYDTHIGMRGVELTQGQKQRIAIARVVLKN 1314

  Fly  1218 PKILILDEATSALDLESEKVVQQALDEARSG-RTCLTIAHRLTTVRNADLICVLKRGVVVEHGTH 1281
            ..||::|||:|:::.||.:|||:|||....| :|.:.||||:..:|:.|.|.||..|.:||.|||
plant  1315 APILLIDEASSSIESESSRVVQEALDTLIMGNKTTILIAHRVAMMRHVDNIVVLNGGKIVEEGTH 1379

  Fly  1282 DELMALNKIYANL 1294
            |.|...|.:|..|
plant  1380 DCLAGKNGLYVRL 1392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	175/492 (36%)
		MdlB	720..1299	CDD:440747	203/584 (35%)
ABCB6	NP_181480.1	MdlB	83..644	CDD:440747	173/484 (36%)
		MdlB	820..1392	CDD:440747	202/582 (35%)