DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB1

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_181228.1	Gene:	ABCB1 / 818265	AraportID:	AT2G36910	Length:	1286	Species:	Arabidopsis thaliana

Alignment Length:	1303	Identity:	446/1303 - (34%)
Similarity:	696/1303 - (53%)	Gaps:	93/1303 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALP 91
            |..::.:|||::...:..|:.:..:.|......:|.|:..:.:..:
plant    25 RGVAFKELFRFADGLDYVLMGIGSVGAFVHGCSLPLFLRFFADLVN------------------- 70

  Fly    92 MFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFL 156
            .||        |...|.:.::::...:.:..||...|::......|.........|..::|..:|
plant    71 SFG--------SNSNNVEKMMEEVLKYALYFLVVGAAIWASSWAEISCWMWSGERQTTKMRIKYL 127

  Fly   157 EAMLRQDIAWYDTS-SGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTL 220
            ||.|.|||.::||. ..|:....:..|...:::.|.||:...:..:.|||.|.:..|...|:|.|
plant   128 EAALNQDIQFFDTEVRTSDVVFAINTDAVMVQDAISEKLGNFIHYMATFVSGFIVGFTAVWQLAL 192

  Fly   221 VVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLL 285
            |.|:.||.|.....:.......|:.|..:|.|.|.|:||:....||.|.||.|:.:..:.:...|
plant   193 VTLAVVPLIAVIGGIHTTTLSKLSNKSQESLSQAGNIVEQTVVQIRVVMAFVGESRASQAYSSAL 257

  Fly   286 IPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIM 350
            ..|:..|.|.||..|||...::.:::.|.||.:|||..|:      ...:....:.:..:|||::
plant   258 KIAQKLGYKTGLAKGMGLGATYFVVFCCYALLLWYGGYLV------RHHLTNGGLAIATMFAVMI 316

  Fly   351 GAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARP 415
            |...||.::|.:.|.|.|..|...:|.|||....::...|.|...::..|.:..:.:.|.||:||
plant   317 GGLALGQSAPSMAAFAKAKVAAAKIFRIIDHKPTIERNSESGVELDSVTGLVELKNVDFSYPSRP 381

  Fly   416 DVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQI 480
            ||:||....:.|..|:|:|.||:||.||||::.|::|||||.:|.|.|||:||:||.:.|||.||
plant   382 DVKILNNFCLSVPAGKTIALVGSSGSGKSTVVSLIERFYDPNSGQVLLDGQDLKTLKLRWLRQQI 446

  Fly   481 GVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQ 545
            |:|.|||.||||:|.|||..|||.|.|.:||:|||.||.|.||.:||.|:||||||:|.|:||||
plant   447 GLVSQEPALFATSIKENILLGRPDADQVEIEEAARVANAHSFIIKLPDGFDTQVGERGLQLSGGQ 511

  Fly   546 KQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVF 610
            |||||||||:::.|.:|||||||||||..|||.||.||:....|.|||::|||||||..||.:..
plant   512 KQRIAIARAMLKNPAILLLDEATSALDSESEKLVQEALDRFMIGRTTLIIAHRLSTIRKADLVAV 576

  Fly   611 LKDGVVAEQGTHEELMER--RGLYCELVSITQ-RKEATEADEGAVAGRPLQK------------- 659
            |:.|.|:|.|||:||..:  .|:|.:|:.:.: ..|...::....:.||...
plant   577 LQQGSVSEIGTHDELFSKGENGVYAKLIKMQEAAHETAMSNARKSSARPSSARNSVSSPIMTRNS 641

  Fly   660 -------SQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKKKKDKEVVS 717
                   |:.|||..|.|.....:....|                      :.|.:|...|:..:
plant   642 SYGRSPYSRRLSDFSTSDFSLSIDASSYP----------------------NYRNEKLAFKDQAN 684

  Fly   718 KVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIF 782
              ||.:|.|:|||||::.::|.:.||:.|:....:.........:..:.|.:.:..::.|...:.
plant   685 --SFWRLAKMNSPEWKYALLGSVGSVICGSLSAFFAYVLSAVLSVYYNPDHEYMIKQIDKYCYLL 747

  Fly   783 VGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSN 847
            :|:...|.:.|.||...:...|..:|.|:|::....::..::|:||.|.|....:.:|||.|.:|
plant   748 IGLSSAALVFNTLQHSFWDIVGENLTKRVREKMLSAVLKNEMAWFDQEENESARIAARLALDANN 812

  Fly   848 VQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKAS 912
            |:.|.|.|:..::|..|.::|....|||..|:..|:.:...|:|..:..|:..|:...:...:|:
plant   813 VRSAIGDRISVIVQNTALMLVACTAGFVLQWRLALVLVAVFPVVVAATVLQKMFMTGFSGDLEAA 877

  Fly   913 IEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYG 977
            ..:.:|:|.|||.|:|||.....|.:::..|...::.....|..|.:..|..:.:.|...:.:|.
plant   878 HAKGTQLAGEAIANVRTVAAFNSEAKIVRLYTANLEPPLKRCFWKGQIAGSGYGVAQFCLYASYA 942

  Fly   978 ISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNV---NDAILSAGRLMDLFKRTS 1039
            :.::|...||.....::...|:|...|:..:....:.|..||:.   ..|:.|...|:|  ::|.
plant   943 LGLWYASWLVKHGISDFSKTIRVFMVLMVSANGAAETLTLAPDFIKGGQAMRSVFELLD--RKTE 1005

  Fly  1040 TQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCV 1104
            .:|:.|.:. ...::..|::..:::.|.||:|....|.:.|:|..:...|:|||||||.|||:.:
plant  1006 IEPDDPDTT-PVPDRLRGEVELKHIDFSYPSRPDIQIFRDLSLRARAGKTLALVGPSGCGKSSVI 1069

  Fly  1105 QLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQE 1169
            .|:.|:|:|.||.|.:.|....::.|..:|..:.:|.|||.||..||.||||||:....:.   |
plant  1070 SLIQRFYEPSSGRVMIDGKDIRKYNLKAIRKHIAIVPQEPCLFGTTIYENIAYGHECATEA---E 1131

  Fly  1170 IIEAAKKSNIHNFISALPQGYDTRLGKTS-QLSGGQKQRIAIARALVRNPKILILDEATSALDLE 1233
            ||:||..::.|.||||||:||.|.:|:.. ||||||||||||||||||..:|::|||||||||.|
plant  1132 IIQAATLASAHKFISALPEGYKTYVGERGVQLSGGQKQRIAIARALVRKAEIMLLDEATSALDAE 1196

  Fly  1234 SEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNK--IYANLYL 1296
            ||:.||:|||:|.||||.:.:||||:|:|||.:|.|:..|.|.|.|:|..|:..:.  |||.:..
plant  1197 SERSVQEALDQACSGRTSIVVAHRLSTIRNAHVIAVIDDGKVAEQGSHSHLLKNHPDGIYARMIQ 1261

  Fly  1297 MQQ 1299
            :|:
plant  1262 LQR 1264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	229/608 (38%)
		ABC_membrane	116..352	CDD:279056	66/236 (28%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	136/235 (58%)
		MdlB	735..1299	CDD:224055	193/569 (34%)
		ABC_membrane	739..998	CDD:279056	60/258 (23%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	118/241 (49%)
ABCB1	NP_181228.1	PTZ00265	43..1264	CDD:240339	441/1283 (34%)
		ABC_membrane	49..319	CDD:279056	74/302 (25%)
		ABC_MTABC3_MDL1_MDL2	368..607	CDD:213216	137/238 (58%)
		ABC_membrane	705..970	CDD:279056	62/264 (23%)
		ABC_MTABC3_MDL1_MDL2	1024..1263	CDD:213216	118/241 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	196	1.000	Domainoid score	I898
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	876	1.000	Inparanoid score	I60
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	1	1.000	-	-		mtm951
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840