DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and abcb5

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	XP_001922717.3	Gene:	abcb5 / 798527	ZFINID:	ZDB-GENE-030131-6414	Length:	1338	Species:	Danio rerio

Alignment Length:	1305	Identity:	549/1305 - (42%)
Similarity:	804/1305 - (61%)	Gaps:	63/1305 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 RKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALP 91
            :...:|.||||:|..|.||:::.||.|.|....:|...:::|:.|...|.       |...:.|.
Zfish    65 KSVGFFQLFRYATCPEVFLMLIGLLCAAAHGVALPLMCVVFGQMTDSFVQ-------SGQTYNLT 122

  Fly    92 MFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMF---------LLITLAIDLANRIALNQ 147
            .|.|...........|....:..:...||...:...|.|         :|.|..:.|....|..|
Zfish   123 GFNGNFTSNFTFTLNNTSTCLAGSPEIGIEPKMTKQAYFFIGIGGAVLVLGTFQVMLFLLTAAKQ 187

  Fly   148 IDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAF 212
            ..|||:.:..|:|.|.::|:||........::|:|::.:.:|:|:||.:.|....:|:.|:|..|
Zfish   188 TKRIRQKYFHAILHQQMSWFDTHPIGELNIRLTDDINTINDGLGDKIAVFVQFFCSFISGLVIGF 252

  Fly   213 VYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKE 277
            |:|||||||:|:..|.:..:.:|.:::..||..|||.:|:.|..|.||:...||||.||:||:|.
Zfish   253 VFGWKLTLVILAVSPLLAGSAAVWSKILASLTSKELTAYAKAGAVAEEILVAIRTVVAFNGQKKA 317

  Fly   278 KERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLV 342
            .|::.|.|:.|::.|.||.:.:.:...|:..|::...|||.|||..|.:||   |:. ||...::
Zfish   318 VEKYEKNLVEAKDFGVKKAISTNVSMGLTQFIVFATYALAFWYGTKLSVDE---PEN-YTIGRVL 378

  Fly   343 IVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGI 407
            .|.|:|::|..:||..:|::||||.|..|...::..||.|..:|...::|::|:...|.|.|:.|
Zfish   379 TVFFSVMIGTFSLGQGAPNLEAIAKARGAAYEVYKTIDMPRPIDSSSKEGHKPDRVRGDIEFKNI 443

  Fly   408 RFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLN 472
            .|.||:|.||.||:|:::.|..|:|:|.||||||||||.|||:||||||::|.|.|||.|:|:||
Zfish   444 NFNYPSRKDVTILQGMSLKVPHGKTIALVGASGCGKSTTIQLLQRFYDPDSGEVTLDGHDIRSLN 508

  Fly   473 VGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEK 537
            |.|||..:|:|.||||||.|||.|||||||..||.||||:|.:.||.:|||::||...:|.|||:
Zfish   509 VRWLRENMGIVSQEPVLFGTTIAENIRYGREDATDADIEQAIKEANAYDFISKLPDKLNTMVGER 573

  Fly   538 GAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTI 602
            |||:|||||||||||||||:.|::|||||||||||..||..||:||:.|..|.||:|:|||||||
Zfish   574 GAQLSGGQKQRIAIARALVKNPKILLLDEATSALDTQSESIVQAALDKARAGRTTIVIAHRLSTI 638

  Fly   603 TNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEE 667
            .:||.|....:|.|.|||:|.|||.::|:|..||  ||:....:.:|           .:.::::
Zfish   639 RSADIIAGFSEGRVVEQGSHRELMAKKGVYYSLV--TQQTSGRQNEE-----------LDANEDD 690

  Fly   668 TDDDEEDE--EEDEEPELQTSG------------SSRDSGFRASTRRKRRSQRRKKKKDKEVVSK 718
            |.||.|:|  |:..:||:...|            |.:.|..|.|:|:|.:..|:.||..||.:.:
Zfish   691 TQDDSEEETGEDSSDPEILEGGVEMKLERGSFRKSLKRSSKRRSSRKKSKKSRKDKKAKKEEIPE 755

  Fly   719 VSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFV 783
            :.||:::.||.|:|.::|||..||::.||.:|...:.|....|:.::.|.:|.|.:.:..|::::
Zfish   756 MPFTKILALNKPDWPYLVVGTFASLVGGAVYPCVAILFAKIIGVFAEPDPEVKRQKTMMFSLLYL 820

  Fly   784 GIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNV 848
            .||::|.|....|.:||..:|..:|.|||.:||..|:.|:|.:|||..|:||.|.::||:|.|.|
Zfish   821 LIGVVAFLTYFFQGFMFGKSGELLTMRLRSQAFKAIVRQEIGWFDDNNNAVGILTTKLATDASLV 885

  Fly   849 QGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASI 913
            :||.|:|:|.....:..|::.::|.|||.||.|||.|..:|.:..:.:::.|.......|.::::
Zfish   886 KGAAGSRLGLATNTICALLIAVIVAFVFCWQLTLLILACVPFLTGANFIQLRATAGHTSKDQSAL 950

  Fly   914 EEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGI 978
            |.:.:::.|.:.|.:||..|..|.....:::..:.....|...|....|:.|||.||.|:|....
Zfish   951 EMSGKISTETVENFKTVVALTREDVFFHKFIDSLSTPYKASLCKAPIYGITFALAQAIPYLVNAA 1015

  Fly   979 SMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPN 1043
            ...:|..|:|.....||::..|...::|.:..:||:.::||:...|..:|||::.|.::     .
Zfish  1016 IFRFGAWLIAHCYTEYENVFLVFSVIVFAAMNIGQSSSFAPDFAKAKAAAGRIIQLLEK-----K 1075

  Fly  1044 PPQSPYNTVEKSE------GDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKST 1102
            |....|:  |..|      |:|.:::|.|.||||....:|||||:::::..|:||||.||.||||
Zfish  1076 PEIDIYD--ESGERPSTFSGNIDFKDVQFSYPTRPNVKVLQGLNVSVRQGQTLALVGSSGCGKST 1138

  Fly  1103 CVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSM 1167
            .:|||.|:|||..|.|.:.|..|....|..||:::|||||||:|||.||:|||.||:|.| .|:.
Zfish  1139 TIQLLERFYDPAGGQVLVDGRDSKSVNLAWLRTQMGLVSQEPILFDCTISENIQYGDNSR-TVTQ 1202

  Fly  1168 QEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALD 1231
            :||.|||||:||||||..||..|:||:| |.:||||||||||||||||||.||:|:|||||||||
Zfish  1203 EEIEEAAKKANIHNFILTLPDKYNTRVGDKGTQLSGGQKQRIAIARALVRKPKLLLLDEATSALD 1267

  Fly  1232 LESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYL 1296
            .||||:||.||||||.||||:.|||||||::|||:|.|::.|.|||.|||.:|||..:.|..| :
Zfish  1268 TESEKIVQAALDEARLGRTCIVIAHRLTTIQNADIIVVVQNGKVVEQGTHAQLMAKQEAYFAL-V 1331

  Fly  1297 MQQVS 1301
            ..|||
Zfish  1332 NAQVS 1336

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	269/614 (44%)
		ABC_membrane	116..352	CDD:279056	83/244 (34%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	146/233 (63%)
		MdlB	735..1299	CDD:224055	247/570 (43%)
		ABC_membrane	739..998	CDD:279056	81/258 (31%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	147/239 (62%)
abcb5	XP_001922717.3	PTZ00265	48..1328	CDD:240339	544/1294 (42%)
		ABC_membrane	88..389	CDD:279056	97/311 (31%)
		ABC_MTABC3_MDL1_MDL2	438..675	CDD:213216	149/238 (63%)
		ABC_membrane	776..1046	CDD:279056	83/269 (31%)
		ABC_MTABC3_MDL1_MDL2	1095..1334	CDD:213216	147/240 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	210	1.000	Domainoid score	I2768
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.730