DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and abcb11a

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	XP_009303249.2	Gene:	abcb11a / 797269	ZFINID:	ZDB-GENE-050517-13	Length:	1320	Species:	Danio rerio

Alignment Length:	1368	Identity:	553/1368 - (40%)
Similarity:	796/1368 - (58%)	Gaps:	130/1368 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MVKKEESRLPQ-------AGDFQLKEGSV--VDATRKYSYFDLFRYSTRCERFLLVVSLLVATAA 56
            |:|.:....|:       |.|..||.|.|  .:......:|.|||:||..|..::||....:...
Zfish     1 MMKNKSGNSPEDSEVIYNAEDADLKNGEVKKKEKAPTVGFFQLFRFSTWREVLMMVVGSFCSLVH 65

  Fly    57 SAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAII--------- 112
            .|..|..:::||..|:..|:..|.:               .:||:.:|...|..|.
Zfish    66 GAATPLMLLVYGMMTNTFVEYEVEI---------------LELTDPNKTCINNTISWMNGSAVQR 115

  Fly   113 -DDATAF-------------------GIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLE 157
             |:.|.:                   |:|.|:.|   |..||..:..|.|    ||.||||.:..
Zfish   116 PDNTTIYCGVDIEAEMTNFALYYIGIGVGVLILS---FFQITFWVSAAAR----QIQRIRKTYFR 173

  Fly   158 AMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVV 222
            .::..:|.|:|.:|.....::|::|::|:...|.:::.|.:..|.||:.|.:..|:.||||||||
Zfish   174 KIMCMEIGWFDCNSVGELNTRMSDDINKINNAIADQVSIFIERISTFIFGFMVGFIGGWKLTLVV 238

  Fly   223 LSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIP 287
            ::..|.:..|..::|.....|..:|||:|:.|..|.:||.|.||||.||.|:.||.||:.:.|:.
Zfish   239 IAVSPLLGLAAGLMAMAVARLTGRELKAYAKAGAVADEVLSSIRTVAAFGGEHKEAERYDRNLVQ 303

  Fly   288 AENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGA 352
            |:..|.|||:..|:.....|.||:||.|||.|:|..|:::.::|     ||..||.|.|.|::||
Zfish   304 AQEWGIKKGMIIGVFQGYLWCIIFLCYALAFWFGSKLVIETQEL-----TPGGLVQVFFGVLIGA 363

  Fly   353 QNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDV 417
            .|||.|||.:||.|...||.:::|:.|||..::|...::|:..:...|.|.|..:.|.||:||:|
Zfish   364 MNLGQASPCLEAFASGRAAAKSIFDTIDREPEIDCFSDEGHTLDKVKGDIEFHSVNFNYPSRPEV 428

  Fly   418 EILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGV 482
            :||..|.:.|..|:|.||||.||.||:|.|||:||||||..|.|.|||.|:|:||:.||||.|||
Zfish   429 KILDDLNIVVKAGETTAFVGPSGSGKTTTIQLIQRFYDPSEGMVSLDGHDIRSLNIQWLRSLIGV 493

  Fly   483 VGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQ 547
            |.||||||||||.|||||||...|..:|.:||:.||.::||..||:.:||.|||.|.|:||||||
Zfish   494 VEQEPVLFATTIAENIRYGRAGVTMQEIIEAAKQANAYNFIMSLPQTFDTLVGEGGGQMSGGQKQ 558

  Fly   548 RIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLK 612
            ||||||||||.|::||||.||||||..||..||.||:.|.||.||:.:|||||||.|||.||..:
Zfish   559 RIAIARALVRNPRILLLDMATSALDNESEAVVQEALDKARQGRTTISIAHRLSTIRNADVIVGFE 623

  Fly   613 DGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEE 677
            .|...|:|||.:|::::|:|..||::..:.:.|:.|          |.:|.::...    .:|.|
Zfish   624 HGRAVERGTHSQLLDKKGVYFTLVTLQNQGKDTDTD----------KPENTAESRV----TEEAE 674

  Fly   678 DEEPELQTSGSSRDSGFRASTRRKRRSQ---------------------------RRKKKKDKEV 715
            .||....:|||     :.:..||:..||                           ::.|.|.||.
Zfish   675 LEELRRFSSGS-----YESVLRRRSLSQLSNSLSVISGKFDFNSDLFEMEESDNNKKSKGKAKED 734

  Fly   716 VSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISM 780
            :......:::|.|.|||.::::|.|.:.::|:..|::.|.|....|..|..|.|..|.::..|.:
Zfish   735 IKPAPVARILKYNRPEWPYMLLGSIGAAINGSLNPMYALLFSQILGTFSIPDPDDQRRQINGICI 799

  Fly   781 IFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDC 845
            :||.||:::.....||.|.|..:|..:|.||||..|..::.|:|.:|||..||.|||.:|||::.
Zfish   800 LFVVIGVVSFFSQFLQGYSFAKSGELLTRRLRKFGFQAMLKQEIGWFDDPMNSPGALTTRLATNA 864

  Fly   846 SNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAK 910
            |.||||||:::|.::.::..:....::.:.|||:.:|:....|||:.||...:.:.:...|.:.|
Zfish   865 SMVQGATGSQIGMIVNSLTNIGASFIIAYYFSWKLSLVVTCFLPLIGLSGVFQSKMLTGLANEDK 929

  Fly   911 ASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLA 975
            .::|.|.||:.||::||||:.||..|:..:.|:.:|:.....|.::|....|:.||..:...|:|
Zfish   930 TALEAAGQVSSEAMSNIRTIAGLAKEKHFVAQFEKQLQAPYKAAKKKAYVYGICFAFARCVIFMA 994

  Fly   976 YGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTST 1040
            |..|..|||.||:.|.:.|..:.:|..||:..:..||:|.::.|:...|.:||.:|..|..|.
Zfish   995 YAASFRYGGYLVSHEGLQYMMVFRVISALVTSATALGRASSFTPDYAKAKISAAQLFQLLDRV-- 1057

  Fly  1041 QPNPPQSPYNTVEKSEGD--------IVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSG 1097
                   |...|.|:||.        :.::...|.||:|....:|:||.:::....|:|.||.||
Zfish  1058 -------PKINVSKTEGQSWNDFKGKVEFKGCRFTYPSRPDVQVLRGLVVSVHPGQTLAFVGSSG 1115

  Fly  1098 SGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFR 1162
            .||||.||||.|:|||..|.|.:.|.||....:..|||::|:|||||||||.:|||||.||:|.|
Zfish  1116 CGKSTSVQLLERFYDPDEGQVLIDGRPSDSISVPFLRSQIGIVSQEPVLFDCSIAENIQYGDNSR 1180

  Fly  1163 DDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEA 1226
             .|||:|||:||||:.:|:|:..||..|:|::| :.||||.|||||||||||:|||||||:||||
Zfish  1181 -TVSMEEIIDAAKKAYLHDFVMTLPDKYETQVGAQGSQLSRGQKQRIAIARAIVRNPKILLLDEA 1244

  Fly  1227 TSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIY 1291
            |||||.||||.||.||||||.||||:.|||||:|:::||:|.|:.:|.|:|.||||||||....|
Zfish  1245 TSALDTESEKTVQAALDEARQGRTCIVIAHRLSTIQSADIIAVMSQGEVIEKGTHDELMAKKAAY 1309

  Fly  1292 ANL 1294
            ..|
Zfish  1310 YKL 1312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	272/634 (43%)
		ABC_membrane	116..352	CDD:279056	88/254 (35%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	141/233 (61%)
		MdlB	735..1299	CDD:224055	247/569 (43%)
		ABC_membrane	739..998	CDD:279056	89/258 (34%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	139/237 (59%)
abcb11a	XP_009303249.2	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	181	1.000	Domainoid score	I3416
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.730