DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and Abcb5

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_084237.1	Gene:	Abcb5 / 77706	MGIID:	1924956	Length:	1255	Species:	Mus musculus

Alignment Length:	1277	Identity:	506/1277 - (39%)
Similarity:	751/1277 - (58%)	Gaps:	76/1277 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 DLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQ 97
            ::||::...:..|:.:.:|.:....|.:|...::.||.:..|::..: |.|:...:
Mouse    36 EIFRFADNLDIVLMTLGILASMINGATVPLMSLVLGEISDHLINGCL-VQTNRTKY--------- 90

  Fly    98 QLTNASKEENNQAIIDDATAFGIGSLVGSVAM--------FLLITLAIDLANRIALNQIDRIRKL 154
            |..:.::|:.|:.|| ..|.:.||  :|:.|:        |.:||         |..|..||||.
Mouse    91 QNCSQTQEKLNEDII-VLTLYYIG--IGAAALIFGYVQISFWVIT---------AARQTTRIRKQ 143

  Fly   155 FLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLT 219
            |..::|.|||:|:|.|......::||.|::||.:|||:||.::...|..|.||:|.:.:..|||:
Mouse   144 FFHSILAQDISWFDGSDICELNTRMTGDINKLCDGIGDKIPLMFQNISGFSIGLVISLIKSWKLS 208

  Fly   220 LVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKL 284
            |||||..|.|:|::::.:|:..||..|||.:||.|..|.||..|.|:||.||..||||.:|:.:.
Mouse   209 LVVLSTSPLIMASSALCSRMIISLTSKELDAYSKAGAVAEEALSSIQTVTAFGAQEKEIQRYTQH 273

  Fly   285 LIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVI 349
            |..|::.|.|:...|.:.....:..:.....||.|||.:||..    .:..||...::.|.|:||
Mouse   274 LKDAKDAGIKRATASKLSLGAVYFFMNGAYGLAFWYGTSLIFG----GEPGYTIGTILAVFFSVI 334

  Fly   350 MGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPAR 414
            ..:..:|..:||:|...||..|...:|.:||:...:|.....|..||...|:|.|:.:.|.||:|
Mouse   335 HSSYCIGSVAPHLETFTVARGAAFNIFQVIDKKPNIDNFSTAGFVPECIEGNIEFKNVSFSYPSR 399

  Fly   415 PDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQ 479
            |..::||||.:.:..|:|||.||.||.||||.:||:||.||||.|.:.:|..|:|..||...|.|
Mouse   400 PSAKVLKGLNLKIKAGETVALVGPSGSGKSTTVQLLQRLYDPEDGCITVDENDIRAQNVRHYREQ 464

  Fly   480 IGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGG 544
            ||||.||||||.||||.||::||....:.::|:|||.||.:|||...||.::|.|||||||:|||
Mouse   465 IGVVRQEPVLFGTTIGNNIKFGREGVGEKEMEQAAREANAYDFIMAFPKKFNTLVGEKGAQMSGG 529

  Fly   545 QKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIV 609
            |||||||||||||.|::|:|||||||||..||..||:|||.||:|.||:|||||||||..||.||
Mouse   530 QKQRIAIARALVRNPKILILDEATSALDTESESLVQTALEKASKGRTTIVVAHRLSTIRGADLIV 594

  Fly   610 FLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEED 674
            .:|||:|.|:|||.|||.::|||..|               |:|                  ::.
Mouse   595 TMKDGMVVEKGTHAELMAKQGLYYSL---------------AMA------------------QDI 626

  Fly   675 EEEDEEPELQTSGSSRDSGFRA-----STRRKRRSQRRKK-KKDKEVVSKVSFTQLMKLNSPEWR 733
            ::.||:.|.:|..::.::.:.:     |.:.....|..:. ...|..:.:||..::.||:..||.
Mouse   627 KKVDEQMESRTCSTAGNASYGSLCDVNSAKAPCTDQLEEAVHHQKTSLPEVSLLKIFKLSKSEWP 691

  Fly   734 FIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTY 798
            |:|:|.:||.::|:..|::.:.||....:..|.:...::.:....||:.|.:|::|.:..::|..
Mouse   692 FVVLGTLASALNGSVHPVFSIIFGKLVTMFEDKNKATLKQDAELYSMMLVVLGIVALVTYLMQGL 756

  Fly   799 MFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAV 863
            .:..|...:..|||..||..::.||:|::||:.|:.|||.:.||.|.:.:|||..:|:|.:.|.|
Mouse   757 FYGRAEENLAMRLRHSAFKAMLYQDMAWYDDKENNTGALTTTLAVDVAQIQGAATSRLGIVTQDV 821

  Fly   864 ATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIR 928
            :.:.:.:::.|::.|:.|||.|...|::.::..::...:...|.:.|.:::.|.::|.||:.|||
Mouse   822 SNMSLSILISFIYGWEMTLLILSFAPVLAVTGMIQTAAMAGFANRDKQALKRAGKIATEAVENIR 886

  Fly   929 TVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMN 993
            ||..|..||.....|.:.:........::....|..:|:..|....|:.....:|..|:...||.
Mouse   887 TVVSLTRERAFEQMYEETLQTQHRNALKRAHITGCCYAVSHAFVHFAHAAGFRFGAYLIQAGRMM 951

  Fly   994 YEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGD 1058
            .|.:..|..|:.:|:..:|:.|.:||..:.|...|..|..|.|...|..:..||. ...:..||:
Mouse   952 PEGMFIVFTAIAYGAMAIGETLVWAPEYSKAKAGASHLFALLKNKPTINSCSQSG-EKPDTCEGN 1015

  Fly  1059 IVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGV 1123
            :.:..|.|.||.|...|:||.::|:|:|..|||.||.||.|||||||||.|:|||:.|.|.|.||
Mouse  1016 LEFREVSFVYPCRPEVPVLQNMSLSIEKGKTVAFVGSSGCGKSTCVQLLQRFYDPMKGQVLLDGV 1080

  Fly  1124 PSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQ 1188
            ...|..:..|||:..:||||||||:.:||||||||:|.| .|.::||.|.|..:|||:||..||:
Mouse  1081 DVKELNVQWLRSQTAIVSQEPVLFNCSIAENIAYGDNSR-MVPLEEIKEVADAANIHSFIEGLPR 1144

  Fly  1189 GYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCL 1252
            .|:|.:| :..|||||||||:||||||:|.||||:|||||||||.|||||||||||:||.|:|||
Mouse  1145 KYNTLVGLRGVQLSGGQKQRLAIARALLRKPKILLLDEATSALDNESEKVVQQALDKARRGKTCL 1209

  Fly  1253 TIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANL 1294
            .:||||:|::|||:|.||:.|.:.|.|||.||:.....|..|
Mouse  1210 VVAHRLSTIQNADMIVVLQNGSIKEQGTHQELLRNGDTYFKL 1251

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	263/613 (43%)
		ABC_membrane	116..352	CDD:279056	89/243 (37%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	142/233 (61%)
		MdlB	735..1299	CDD:224055	227/561 (40%)
		ABC_membrane	739..998	CDD:279056	69/258 (27%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	139/237 (59%)
Abcb5	NP_084237.1	PTZ00265	48..1250	CDD:240339	503/1262 (40%)
		ABC_membrane	53..334	CDD:279056	100/306 (33%)
		ABC_MTABC3_MDL1_MDL2	387..624	CDD:213216	145/269 (54%)
		ABC_membrane	697..963	CDD:279056	71/265 (27%)
		ABC_MTABC3_MDL1_MDL2	1017..1252	CDD:213216	139/236 (59%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2870
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.730