Protein Alignment Mdr49 and TAP1

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_000584.3
• Gene: TAP1 / 6890
• HGNCID: 43
• Length: 748
• Species: Homo sapiens
• Alignment Length: 545
• Identity: 176/545 - (32%)
• Similarity: 279/545 - (51%)
• Gaps: 38/545 - (6%)

  Fly   762 ILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAY 826
            ||.||..|.....:..:|::.:...::..:|:.:..   .|.| .:.:.|:...||.::.|:..:
Human   215 ILQDGSADTFTRNLTLMSILTIASAVLEFVGDGIYN---NTMG-HVHSHLQGEVFGAVLRQETEF 275

  Fly   827 FDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSW---QQTLLTLVTL 888
            |  ::|..|.:.||:..|.|.:..:....:...|.   .||.|:.:..:..|   ..|::||:||
Human   276 F--QQNQTGNIMSRVTEDTSTLSDSLSENLSLFLW---YLVRGLCLLGIMLWGSVSLTMVTLITL 335

  Fly   889 PLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIA 953
            ||:.|.....|::......:.:.|:.::||||:||::.:.||.....|.....::.:::..:...
Human   336 PLLFLLPKKVGKWYQLLEVQVRESLAKSSQVAIEALSAMPTVRSFANEEGEAQKFREKLQEIKTL 400

  Fly   954 CRRKVRFRGLVFALGQ-----AAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQ 1013
            .:::    .:.:|:..     :...|..|| :|.||.||....::..:::    ..:.......|
Human   401 NQKE----AVAYAVNSWTTSISGMLLKVGI-LYIGGQLVTSGAVSSGNLV----TFVLYQMQFTQ 456

  Fly  1014 A----LAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGT 1074
            |    |:..|.|..|:.|:.::.:...||   |..|.|...|....||.:.:::|.|.||.|...
Human   457 AVEVLLSIYPRVQKAVGSSEKIFEYLDRT---PRCPPSGLLTPLHLEGLVQFQDVSFAYPNRPDV 518

  Fly  1075 PILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGL 1139
            .:||||..|::.....|||||:||||||...||...|.|..|.:.|.|.|..::....|..::..
Human   519 LVLQGLTFTLRPGEVTALVGPNGSGKSTVAALLQNLYQPTGGQLLLDGKPLPQYEHRYLHRQVAA 583

  Fly  1140 VSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLGKT-SQLSGG 1203
            |.|||.:|.|::.||||||  .....:|:||..||.||..|:|||.|||||||.:.:. ||||||
Human   584 VGQEPQVFGRSLQENIAYG--LTQKPTMEEITAAAVKSGAHSFISGLPQGYDTEVDEAGSQLSGG 646

  Fly  1204 QKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEA--RSGRTCLTIAHRLTTVRNADL 1266
            |:|.:|:||||:|.|.:||||:||||||..|:..|:|.|.|:  |..|:.|.|...|:.|..||.
Human   647 QRQAVALARALIRKPCVLILDDATSALDANSQLQVEQLLYESPERYSRSVLLITQHLSLVEQADH 711

  Fly  1267 ICVLKRGVVVEHGTHDELMALNKIY 1291
            |..|:.|.:.|.|||.:||.....|
Human   712 ILFLEGGAIREGGTHQQLMEKKGCY 736

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055
		ABC_membrane	116..352	CDD:279056
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216
		MdlB	735..1299	CDD:224055	176/545 (32%)
		ABC_membrane	739..998	CDD:279056	53/243 (22%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	108/236 (46%)
TAP1	NP_000584.3	3a01208	18..740	CDD:273363	176/545 (32%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910