DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr49 and abcb11b

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:XP_003199513.2 Gene:abcb11b / 571189 ZFINID:ZDB-GENE-050517-14 Length:1348 Species:Danio rerio


Alignment Length:1347 Identity:545/1347 - (40%)
Similarity:788/1347 - (58%) Gaps:107/1347 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly     3 KKEESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIY 67
            |||||.:                  :..:|.|||:::..|.:::|...|.|.|..:..|..::::
Zfish    46 KKEESAI------------------RVGFFQLFRFASCREIWMMVFGSLCAIAHGSAQPLMLLVF 92

  Fly    68 GEFTSLLVDRTVGVG-TSSPAFALPMFGGGQQLTNASKEEN-------NQAIID---DATAF--- 118
            |..|...:|..:.:. .|.|..|  ......|..|.::|||       :..::|   :.|.|   
Zfish    93 GMLTDTFIDYDIELNELSDPQKA--CVNNTIQWRNLTQEENLALNMTRSCGLLDIEYEMTNFAYY 155

  Fly   119 --GIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTE 181
              |||:     .:|:|..|.|.|....|..||..|||::...::|.:|.|:|.:|.....::|::
Zfish   156 YVGIGA-----GVFILGYLQISLWITAAARQIQIIRKMYFRKVMRMEIGWFDCTSVGELNTRMSD 215

  Fly   182 DLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEK 246
            |::|:.:.|.:::.|.:....|||.|.:..|..|||||||::|..|.|.....::|.....|...
Zfish   216 DINKINDAIADQVGIFIQRFTTFVCGFLMGFARGWKLTLVIISVSPLIGIGAGLMALFVAKLTGM 280

  Fly   247 ELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIY 311
            ||::|:.|..|.:||.|.:|||.||.|::||.:|:.:.||.|:..|.:|||..|......|.||:
Zfish   281 ELQAYAKAGAVADEVLSSVRTVAAFGGEKKEVDRYDRNLISAQQWGIRKGLIMGFFTGYMWFIIF 345

  Fly   312 LCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLF 376
            ||.|||.|||.:|::|.::     |:|..|:.|.|.|::.|.|||.|||.:||.|....|...:|
Zfish   346 LCYALAFWYGSSLVVDTQE-----YSPGTLLQVFFGVLIAALNLGQASPCLEAFAAGRGAATIIF 405

  Fly   377 NIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGC 441
            ..|||..::|.:.|.|.:.:...|.:.|..|.|.||:||:|:||..|.:.|..|:|.||||.||.
Zfish   406 ETIDREPEIDCLSEAGYKLDKVKGDLEFHNITFHYPSRPEVKILDQLNLQVKSGETTAFVGPSGA 470

  Fly   442 GKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSAT 506
            ||||.|||:||||||:.|.:.|||.|:|.||:.||||.||:|.||||||||||.||||||||..:
Zfish   471 GKSTAIQLIQRFYDPKEGMLTLDGHDIRGLNIQWLRSLIGIVEQEPVLFATTIAENIRYGRPGVS 535

  Fly   507 QADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSAL 571
            ..||..||:.||.::||..||:.::|.|||.|.|:||||||||||||||||.|::||||.|||||
Zfish   536 NDDIITAAKEANAYNFIMDLPQKFETLVGEGGGQMSGGQKQRIAIARALVRNPRILLLDMATSAL 600

  Fly   572 DPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELV 636
            |..||..||.||:....|.||:.:|||||||.|||.||..:.|...|:|.|:||:||:|:|..||
Zfish   601 DNESEAVVQEALDKVRMGRTTISIAHRLSTIKNADVIVGFEHGRAVERGKHDELLERKGVYFTLV 665

  Fly   637 SI-TQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRR 700
            :: :|..:|..           ||:|    :|.::.|..:.:.|...|..:||.|.| .|||..:
Zfish   666 TLQSQGDKALN-----------QKAQ----QEMEEAECCDSDAERRSLNRAGSYRAS-LRASIHQ 714

  Fly   701 KRRSQRRKKKKDKEV---------------------------------VSKVSFTQLMKLNSPEW 732
            :.|||......:..|                                 |......:::|.|:|||
Zfish   715 RSRSQLSNAVPESSVAIAGELGPRSYSETTVPQEFMGKSGVPEDTAEEVEPAPVARILKYNAPEW 779

  Fly   733 RFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQT 797
            .::..|.|.:.::|...|::.|.|.......|..|....|.|:..|.:.||.:||::....|||.
Zfish   780 PYMFFGSIGAAVNGGVNPVYSLLFSQILATFSMPDPVEQRREINGICLFFVVVGLVSFFTQMLQG 844

  Fly   798 YMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQA 862
            |.|:.:|..:|.|||:..|..::||:|.:|||.:||.|||.:|||:|.|.||||||:::|.::.:
Zfish   845 YAFSKSGELLTRRLRRLGFQAMLGQEIGWFDDRKNSPGALTTRLATDASQVQGATGSQIGMIVNS 909

  Fly   863 VATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNI 927
            :..:.|.:::.|.|||:.||:.|..||.:.||...:.:.:...|::.|.::|.|.|::.||:.||
Zfish   910 LTNIGVAVIISFYFSWKLTLVILCFLPFLALSGGFQAKMLTGFAKQDKEAMETAGQISGEALNNI 974

  Fly   928 RTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERM 992
            ||:.||..||..::.:..|::....|..:|....|..:...|...|:|...|..:||.||..|.:
Zfish   975 RTIAGLGKERNFVEMFETQLEAPYQAALKKANVYGACYGFAQCVVFMANSASYRFGGYLVYHEGL 1039

  Fly   993 NYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYN----TVE 1053
            ::..:.:|..|::.....||:|.:|.|:...|.:||.|...|..|.     |..|.|:    ..:
Zfish  1040 HFSFVFRVISAIVTSGTALGRASSYTPDYAKAKISAARFFQLLDRI-----PKISVYSKDGQKWD 1099

  Fly  1054 KSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSV 1118
            ..:|||.:.:..|.||:|....:|.|||:::|...|:|.||.||.||||.||||.|:|||.||.|
Zfish  1100 NFKGDIEFIDCKFTYPSRPDIQVLNGLNVSVKPGQTLAFVGSSGCGKSTSVQLLERFYDPNSGRV 1164

  Fly  1119 NLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFI 1183
            .:.|..|::..:..||||:|:|||||:|||.:|||||.||:|.| ::||.::|.||||:.:|:|:
Zfish  1165 LIDGRESSQINVAYLRSKIGIVSQEPILFDCSIAENIRYGDNQR-ELSMNDVISAAKKAQLHDFV 1228

  Fly  1184 SALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARS 1247
            .:||:.|||.:| :.||||.|||||||||||::|:||||:|||||||||.||||.||:|||:||.
Zfish  1229 MSLPEKYDTNVGSQGSQLSRGQKQRIAIARAIIRDPKILLLDEATSALDTESEKTVQEALDKARE 1293

  Fly  1248 GRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANL 1294
            ||||:.|||||:|::|:|:|.|:.||.|:|.||||.||.|...|..|
Zfish  1294 GRTCIVIAHRLSTIQNSDIIAVMSRGYVIEKGTHDYLMGLKGAYYKL 1340

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 269/622 (43%)
ABC_membrane 116..352 CDD:279056 87/240 (36%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 140/233 (60%)
MdlB 735..1299 CDD:224055 244/565 (43%)
ABC_membrane 739..998 CDD:279056 88/258 (34%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 137/237 (58%)
abcb11bXP_003199513.2 ABC_membrane 76..382 CDD:279056 103/317 (32%)
PTZ00265 157..1339 CDD:240339 515/1213 (42%)
ABC_MTABC3_MDL1_MDL2 432..668 CDD:213216 142/235 (60%)
ABC_membrane 787..1053 CDD:279056 90/265 (34%)
ABC_MTABC3_MDL1_MDL2 1105..1344 CDD:213216 137/237 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 181 1.000 Domainoid score I3416
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_100059
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
87.860

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