DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Mdr49 and abcb9

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001119906.1	Gene:	abcb9 / 570148	ZFINID:	ZDB-GENE-050517-12	Length:	789	Species:	Danio rerio

Alignment Length:	709	Identity:	230/709 - (32%)
Similarity:	358/709 - (50%)	Gaps:	112/709 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVS-----LLVATAASAFIPYFM 64
            |..:..::|......|:.:.  |..||         |::...::|     ||::....|||||
Zfish   163 ESEKSMKSGKEHTHSGATIG--RLLSY---------CKKDSSLLSIAFFFLLLSAVCEAFIPY-- 214

  Fly    65 IIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAM 129
                 :|...:|..| :..|...||.||.                       ...:.:||.|:|:
Zfish   215 -----YTGQAIDGIV-IQKSMDHFAKPMI-----------------------TLSVLALVSSIAI 250

  Fly   130 -----FLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEG 189
                 ...:|.|     |:.:    |:|.|...:::.|:|.::|.:...:..|::|.|..::.:.
Zfish   251 GFRGGVFSVTFA-----RLNI----RLRNLLFRSLMHQEIGFFDANHTGDITSRLTSDTTQVSDL 306

  Fly   190 IGEKIVIVVFLIMTFV--IGIVSAFVYG--WKLTLVVLSCVPFIIAATSVVARLQGSLAEKELK- 249
            |.:.:.:   .:.:||  :||. .|::|  |||::|.:...|:|    :||::|.|...:|..|
Zfish   307 ISQNVNL---FLRSFVKAVGIF-IFMFGMSWKLSVVTIMGFPYI----AVVSKLYGEYYKKLTKE 363

  Fly   250 ---SYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGL-YSGMGNALSW--L 308
               :.:.|..|.||..|.:|||.:|:.:::|.:.:...|.......:|:.: |:    ...|  .
Zfish   364 VQTALAQANKVAEETISAMRTVRSFANEDQEGDMYYSRLQEMFVLNKKQAIAYA----CFMWSSY 424

  Fly   309 IIYLCMALAI-WYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAG 372
            |..|.:.:|| :||..|:     :.:::....::..|::.:.:| :.|...|.....:.....|.
Zfish   425 ISELALQVAILFYGGHLV-----VTNQMSGGTLISFVIYELELG-EALESISSVYTGLMQGVGAA 483

  Fly   373 QTLFNIIDR-PSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFV 436
            :.:|..||| |.......|   .||...|.:.|..:.|.||:||::::||.::..:.|||..|.|
Zfish   484 EKVFEYIDRKPKHALNGQE---APETLEGQVEFNNVTFAYPSRPEMDVLKNVSFSLRPGQVTALV 545

  Fly   437 GASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYG 501
            |.||.|||:.:.|::.||.|:.|.|.:|||.:.|....:..|::.:|.|||||||.|:..||.||
Zfish   546 GPSGGGKSSCVCLLENFYAPQQGQVLVDGRPVNTYQHKYYHSKVALVAQEPVLFARTVQMNISYG 610

  Fly   502 RPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDE 566
            .|.|....:.:||..||.|||||.|.||||:.|||||.|:|||||||:||||||:|.|::|:|||
Zfish   611 VPEAPMEAVIRAAINANAHDFITGLSKGYDSGVGEKGTQLSGGQKQRVAIARALIRSPRILILDE 675

  Fly   567 ATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGL 631
            ||||||..||..||.||....:..|.||:||||||:..||.|:.:..|.|.|||.|.|||.|.||
Zfish   676 ATSALDSESEYIVQQALNNLMREHTVLVIAHRLSTVERADNILVIDKGSVVEQGPHAELMARGGL 740

  Fly   632 YCELVSITQRK-EATEADEGAVAGRPLQKSQNLSDEET----DDDEEDEEEDEEPELQT 685
            ||:||   ||: ..||.|         ...:|.|...|    .:|:|:.|:..:.|.:|
Zfish   741 YCKLV---QRQILGTEID---------VDDKNPSPAPTWELKTEDKENAEDCSDTEYET 787

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	211/628 (34%)
		ABC_membrane	116..352	CDD:279056	57/252 (23%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	122/233 (52%)
		MdlB	735..1299	CDD:224055
		ABC_membrane	739..998	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216
abcb9	NP_001119906.1	3a01208	46..745	CDD:273363	215/653 (33%)
		ABC_membrane	199..458	CDD:279056	72/315 (23%)
		P-loop_NTPase	500..725	CDD:304359	113/227 (50%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810