DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and Abcb10

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_062425.1	Gene:	Abcb10 / 56199	MGIID:	1860508	Length:	715	Species:	Mus musculus

Alignment Length:	622	Identity:	223/622 - (35%)
Similarity:	340/622 - (54%)	Gaps:	68/622 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   704 SQRRKKKKDKEVVSKVSFTQLMKLNSPE-------WRFIVVGGIASVMHGATFPLWGLFFGDFFG 761
            ||||.....:..|.|     |:.|..||       ..|:.|..:.::  .|.|     |.|....
Mouse   110 SQRRPAATGRSEVWK-----LLGLVRPERGRLSAAVGFLAVSSVITM--SAPF-----FLGRIID 162

  Fly   762 IL----SDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQ 822
            ::    |:|..|    .:.::..:...:.|.....|.::.|:..::|..:..|||...|.:|:.|
Mouse   163 VIYTNPSEGYGD----SLTRLCAVLTCVFLCGAAANGIRVYLMQSSGQSIVNRLRTSLFSSILRQ 223

  Fly   823 DIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLV- 886
            ::|:||..|  .|.|.:||:||.:.:..:....:...|:|.|...||  ||.:|....:|.|.|
Mouse   224 EVAFFDKTR--TGELINRLSSDTALLGRSVTENLSDGLRAGAQASVG--VGMMFFVSPSLATFVL 284

  Fly   887 -TLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRV 950
             .:|.:.:...:.||::.|.::..:.|:.||:|:|.|.|.||||:.....|...:::|..::|::
Mouse   285 SVVPPISVLAVIYGRYLRKLSKATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTGRVDQL 349

  Fly   951 DIACRRKVRFRGLVFALGQAAPFLAYGIS--------MYYGGILVAEERMNYEDIIKVAEALIFG 1007
            ....:::        ||.:|..|.|.|:|        :|.||:|:....|.   :.:::..|::.
Mouse   350 LQLAQKE--------ALARAGFFGAAGLSGNLIVLSVLYKGGLLMGSAHMT---VGELSSFLMYA 403

  Fly  1008 SWM---LGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYN----TVEKS-EGDIVYENV 1064
            .|:   :|...::...:...:.:.|||.:|.:|      .|:.|:|    ..||: :|.:.:.||
Mouse   404 FWVGLSIGGLSSFYSELMKGLGAGGRLWELLER------QPRLPFNEGMVLDEKTFQGALEFRNV 462

  Fly  1065 GFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFP 1129
            .|.||.|....:.|..:|:|...:..||||||||||||.|.||||.|||.||:|:|.|....:..
Mouse   463 HFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRLYDPNSGTVSLDGHDIRQLN 527

  Fly  1130 LDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRL 1194
            ...||||:|.||||||||..::|||||||.:....|:.|::..||:.:|...||.:.|||:||.:
Mouse   528 PVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTAQQVERAAEVANAAEFIRSFPQGFDTVV 592

  Fly  1195 G-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRL 1258
            | |...|||||||||||||||::|||||:|||||||||.|:|.:||:|||....|||.|.|||||
Mouse   593 GEKGILLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHRL 657

  Fly  1259 TTVRNADLICVLKRGVVVEHGTHDELMAL-NKIYANL 1294
            :|::||:.:.||..|.:.|||||:||:.. |.:|..|
Mouse   658 STIKNANFVAVLDHGKICEHGTHEELLLKPNGLYRKL 694

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055
		ABC_membrane	116..352	CDD:279056
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216
		MdlB	735..1299	CDD:224055	212/584 (36%)
		ABC_membrane	739..998	CDD:279056	68/272 (25%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	129/238 (54%)
Abcb10	NP_062425.1	3a01208	8..694	CDD:273363	222/620 (36%)
		ABC_membrane	142..403	CDD:279056	71/286 (25%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	129/237 (54%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.910