Protein Alignment Mdr49 and tap2t

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_005156356.1
• Gene: tap2t / 556826
• ZFINID: ZDB-GENE-130531-48
• Length: 728
• Species: Danio rerio
• Alignment Length: 664
• Identity: 210/664 - (31%)
• Similarity: 330/664 - (49%)
• Gaps: 110/664 - (16%)

  Fly     6 ESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAA--SAFIPY-----F 63
            |...|..|..:.......|...:.....:.|||.....:|....:.::.||  ..||||     .
Zfish   128 EMAFPHGGSSKGGRNQKKDEEARALLMRVIRYSRLDYLYLGAAFIFLSLAALFETFIPYCTGKVI 192

  Fly    64 MIIYGEFT------SLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGS 122
            .|:.|::.      ::|:.....:|:|       ||.|
Zfish   193 DILSGKYQHSNFTWAILLLALCSLGSS-------MFSG--------------------------- 223

  Fly   123 LVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLK 187
            |.|.:.||.|        ||  ||:  |||.|..:.:::|:|.::|.....|.||::..|.||:.
Zfish   224 LRGGMFMFSL--------NR--LNK--RIRNLLFQNVMKQEIDFFDEIKPGNLASRLISDTDKMG 276

  Fly   188 EGIGEKI-VIVVFLIMT-----FVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQ---GSL 243
            ..:...: |::..::.|     |::|:      .|:|||  |:|:..     .::|.||   .||
Zfish   277 RAVAMNVNVLLRSMVKTCGMLYFMLGV------SWQLTL--LTCIEM-----PLLAFLQNSYNSL 328

  Fly   244 AEKELKSYSD----AANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNA 304
            ::|..|...|    ...:...|...|:||.:|..:.:|::|:.:.:.......|:||.||.
Zfish   329 SQKTSKELQDCNAETGELASSVIGSIKTVRSFKAECQEQQRYEQTINRKLQVLRRKGFYSA---- 389

  Fly   305 LSWLIIYLCMALAIWYG--VTLILDERDL--PDRVYTPAVLVIVLFA--VIMGAQNLGFASPHVE 363
                 :||.:...|..|  |.::...|:|  ..::.:.::|..|.:.  ::...::|    .::.
Zfish   390 -----VYLLIRRFITVGLKVAMLCQGRNLISSGQLSSGSLLAFVFYQKDMVTSMKHL----VYIY 445

  Fly   364 AIAVATAAGQT-LFNIIDRPSQVDPMDEKGN-RPENTAGHIRFEGIRFRYPARPDVEILKGLTVD 426
            ...::|..... :|.::||..|   |.|.|: .||...|.|.||.:.|.|.:|||...||.:|::
Zfish   446 GDMLSTVGSSVKVFQLLDRKPQ---MREAGDLAPEKLKGRITFEKVTFSYLSRPDDTALKSVTLE 507

  Fly   427 VLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFA 491
            :.||:..|.||.||.|||:.:.|:||||:|:.|.:.|||..|......:|..::.||.|:||||:
Zfish   508 LSPGKLTALVGPSGGGKSSCVSLLQRFYEPKEGEMFLDGEPLYHYQHQYLHKKVAVVSQDPVLFS 572

  Fly   492 TTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALV 556
            .::..||.||....|...||:|||.||.|:||..|.:||||.|||.|.|:|.||||.|||||||:
Zfish   573 GSVRYNIEYGLQDCTLERIEEAARKANAHNFICNLEQGYDTDVGECGGQLSAGQKQCIAIARALI 637

  Fly   557 RQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGT 621
            |.||:|:||||||.:|.::::.:|..|...:. .|.||:||||.||..||.|:|::.|.|.||||
Zfish   638 RNPQILILDEATSHMDSSTQQAIQDVLNSITD-QTVLVIAHRLETIEKADHIIFMEGGEVKEQGT 701

  Fly   622 HEELMERRGLYCEL 635
            |::||:::|.|..|
Zfish   702 HQQLMDKQGRYHRL 715

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	203/626 (32%)
		MdlB	720..1299	CDD:440747
tap2t	XP_005156356.1	3a01208	28..715	CDD:273363	209/662 (32%)