DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB4

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	XP_011514610.3	Gene:	ABCB4 / 5244	HGNCID:	45	Length:	1384	Species:	Homo sapiens

Alignment Length:	1307	Identity:	555/1307 - (42%)
Similarity:	806/1307 - (61%)	Gaps:	74/1307 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 GDFQL-----KEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTS 72
            |||:|     ::.......:......|||||...::..:.:..::|.|..:.:|..||::||.|.
Human   109 GDFELGISSKQKRKKTKTVKMIGVLTLFRYSDWQDKLFMSLGTIMAIAHGSGLPLMMIVFGEMTD 173

  Fly    73 LLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAI 137
            ..|| |.|..:....|:|.:...|:.|     ||.........:..|.|.||.:.......|||
Human   174 KFVD-TAGNFSFPVNFSLSLLNPGKIL-----EEEMTRYAYYYSGLGAGVLVAAYIQVSFWTLA- 231

  Fly   138 DLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIM 202
                  |..||.:||:.|..|:|||:|.|:|.:..:...:::|:|:.|:.||||:|:.:....:.
Human   232 ------AGRQIRKIRQKFFHAILRQEIGWFDINDTTELNTRLTDDISKISEGIGDKVGMFFQAVA 290

  Fly   203 TFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRT 267
            ||..|.:..|:.|||||||:::..|.:..:.:|.|::..:.::|||.:|:.|..|.||....|||
Human   291 TFFAGFIVGFIRGWKLTLVIMAISPILGLSAAVWAKILSAFSDKELAAYAKAGAVAEEALGAIRT 355

  Fly   268 VFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLP 332
            |.||.||.||.||:.|.|..|:..|.||.:.:.:...:::|:||...|||.|||.||::.:.
Human   356 VIAFGGQNKELERYQKHLENAKEIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKE--- 417

  Fly   333 DRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPEN 397
               ||....:.|.|::::||.::|.|:|.::|.|.|..|...:|:|||...::|...|:|::|::
Human   418 ---YTIGNAMTVFFSILIGAFSVGQAAPCIDAFANARGAAYVIFDIIDNNPKIDSFSERGHKPDS 479

  Fly   398 TAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVK 462
            ..|::.|..:.|.||:|.:|:|||||.:.|..|||||.||:|||||||.:||:||.|||:.|::.
Human   480 IKGNLEFNDVHFSYPSRANVKILKGLNLKVQSGQTVALVGSSGCGKSTTVQLIQRLYDPDEGTIN 544

  Fly   463 LDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLP 527
            :||:|:|..||.:||..||||.||||||:|||.|||.|||.:.|..:|:||.:.||.::||.:||
Human   545 IDGQDIRNFNVNYLREIIGVVSQEPVLFSTTIAENICYGRGNVTMDEIKKAVKEANAYEFIMKLP 609

  Fly   528 KGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTT 592
            :.:||.|||:|||:||||||||||||||||.|::|||||||||||..||..||:||:.|.:|.||
Human   610 QKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREGRTT 674

  Fly   593 LVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPL 657
            :|:||||||:.|||.|...:|||:.|||:|.|||::.|:|.:||::            ..:|..:
Human   675 IVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELMKKEGVYFKLVNM------------QTSGSQI 727

  Fly   658 QKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSG-FRASTRRK-RRSQRRKKKKDKEV----- 715
            |            .||.|..||:...:.:.:...|. ||.||::. :.||..:|..|.|.
Human   728 Q------------SEEFELNDEKAATRMAPNGWKSRLFRHSTQKNLKNSQMCQKSLDVETDGLEA 780

  Fly   716 -VSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKIS 779
             |..|||.:::|||..||.:.|||.:.::.:|...|.:.:.|.:...|...|||.|.:.:....|
Human   781 NVPPVSFLKVLKLNKTEWPYFVVGTVCAIANGGLQPAFSVIFSEIIAIFGPGDDAVKQQKCNIFS 845

  Fly   780 MIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASD 844
            :||:.:|:::.....||.:.|..||..:|.|||..||..::.||:::|||.:||.|||.:|||:|
Human   846 LIFLFLGIISFFTFFLQGFTFGKAGEILTRRLRSMAFKAMLRQDMSWFDDHKNSTGALSTRLATD 910

  Fly   845 CSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKA 909
            .:.||||||.|:..:.|.:|.|..|:::.|::.||.|||.|..:|::.:|..:|.:.:..:|::.
Human   911 AAQVQGATGTRLALIAQNIANLGTGIIISFIYGWQLTLLLLAVVPIIAVSGIVEMKLLAGNAKRD 975

  Fly   910 KASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFL 974
            |..:|.|.::|.|||.|||||..|..||:....||:::........:|....|:.|::.||..:.
Human   976 KKELEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLYGPYRNSVQKAHIYGITFSISQAFMYF 1040

  Fly   975 AYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTS 1039
            :|.....:|..|:....|.:.|:|.|..|::||:..||.|.::||:...|.|||..|..||:|
Human  1041 SYAGCFRFGAYLIVNGHMRFRDVILVFSAIVFGAVALGHASSFAPDYAKAKLSAAHLFMLFER-- 1103

  Fly  1040 TQPNPPQSPYN----TVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGK 1100
               .|....|:    ..:|.||:|.:..|.|.||||...|:||||:|.:||..|:||||.||.||
Human  1104 ---QPLIDSYSEEGLKPDKFEGNITFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALVGSSGCGK 1165

  Fly  1101 STCVQLLLRYYDPVSGSV-------NLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYG 1158
            ||.||||.|:|||::|:|       .|.|..:.:..:..||::||:|||||:|||.:||||||||
Human  1166 STVVQLLERFYDPLAGTVFVDFGFQLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAENIAYG 1230

  Fly  1159 NNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILI 1222
            :|.| .||..||:.|||.:|||.||..||..|:||:| |.:||||||||||||||||:|.|:||:
Human  1231 DNSR-VVSQDEIVSAAKAANIHPFIETLPHKYETRVGDKGTQLSGGQKQRIAIARALIRQPQILL 1294

  Fly  1223 LDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMAL 1287
            |||||||||.|||||||:|||:||.||||:.|||||:|::|||||.|.:.|.|.|||||.:|:|.
Human  1295 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQ 1359

  Fly  1288 NKIYANL 1294
            ..||.::
Human  1360 KGIYFSM 1366

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	266/605 (44%)
		ABC_membrane	116..352	CDD:279056	83/235 (35%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	140/233 (60%)
		MdlB	735..1299	CDD:224055	259/572 (45%)
		ABC_membrane	739..998	CDD:279056	86/258 (33%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	147/244 (60%)
ABCB4	XP_011514610.3	AAA	108..1369	CDD:333001	555/1307 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2881
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R932
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.760