DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and ABCB1

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001335874.1	Gene:	ABCB1 / 5243	HGNCID:	40	Length:	1350	Species:	Homo sapiens

Alignment Length:	1344	Identity:	566/1344 - (42%)
Similarity:	807/1344 - (60%)	Gaps:	112/1344 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 KKEESRLPQAGD----------FQLKEGSVVDATRK---YSYFDLFRYSTRCERFLLVVSLLVAT 54
            |:.|..:...||          |:|...|..|...|   .|.|.:||||...::..:||..|.|.
Human    65 KEREVGMDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAI 129

  Fly    55 AASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAF- 118
            ...|.:|..|:::||.|.:                   |.....|.:......|::.|:|...|
Human   130 IHGAGLPLMMLVFGEMTDI-------------------FANAGNLEDLMSNITNRSDINDTGFFM 175

  Fly   119 --------------GIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDT 169
                          |||:.| .||.::.::.....|.|    ||.:|||.|..|::||:|.|:|.
Human   176 NLEEDMTRYAYYYSGIGAGV-LVAAYIQVSFWCLAAGR----QIHKIRKQFFHAIMRQEIGWFDV 235

  Fly   170 SSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATS 234
            .......:::|:|:.|:.||||:||.:....:.||..|.:..|..|||||||:|:..|.:..:.:
Human   236 HDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAA 300

  Fly   235 VVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYS 299
            |.|::..|..:|||.:|:.|..|.|||.:.||||.||.||:||.||:.|.|..|:..|.||.:.:
Human   301 VWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITA 365

  Fly   300 GMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEA 364
            .:....::|:||...|||.|||.||:|...      |:...::.|.|:|::||.::|.|||.:||
Human   366 NISIGAAFLLIYASYALAFWYGTTLVLSGE------YSIGQVLTVFFSVLIGAFSVGQASPSIEA 424

  Fly   365 IAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLP 429
            .|.|..|...:|.|||....:|...:.|::|:|..|::.|..:.|.||:|.:|:|||||.:.|..
Human   425 FANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQS 489

  Fly   430 GQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTI 494
            |||||.||.|||||||.:|||||.|||..|.|.:||:|:||:||.:||..||||.||||||||||
Human   490 GQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTI 554

  Fly   495 GENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQP 559
            .|||||||.:.|..:||||.:.||.:|||.:||..:||.|||:|||:||||||||||||||||.|
Human   555 AENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNP 619

  Fly   560 QVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEE 624
            ::|||||||||||..||..||.||:.|.:|.||:|:||||||:.|||.|....|||:.|:|.|:|
Human   620 KILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDE 684

  Fly   625 LMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSS 689
            ||:.:|:|.:||::                      |...:|...::..||.:.|...|:.  ||
Human   685 LMKEKGIYFKLVTM----------------------QTAGNEVELENAADESKSEIDALEM--SS 725

  Fly   690 RDSGFRASTRRK---RRSQRRKKKKDKEVVSK---------VSFTQLMKLNSPEWRFIVVGGIAS 742
            .||  |:|..||   |||.|..:.:|:::.:|         |||.::||||..||.:.|||...:
Human   726 NDS--RSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCA 788

  Fly   743 VMHGATFPLWGLFFGDFFGILSDGDD-DVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVK 806
            :::|...|.:.:.|....|:.:..|| :..|......|::|:.:|:::.:...||.:.|..||..
Human   789 IINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEI 853

  Fly   807 MTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMV 871
            :|.|||...|.:::.||:::|||.:|:.|||.:|||:|.:.|:||.|:|:..:.|.:|.|..|::
Human   854 LTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGII 918

  Fly   872 VGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLE 936
            :.|::.||.|||.|..:|::.::..:|.:.:...|.|.|..:|.:.::|.|||.|.|||..|..|
Human   919 ISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQE 983

  Fly   937 RQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVA 1001
            ::....|.|.:........||....|:.|:..||..:.:|.....:|..|||.:.|::||::.|.
Human   984 QKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVF 1048

  Fly  1002 EALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRT------STQPNPPQSPYNTVEKSEGDIV 1060
            .|::||:..:||..::||:...|.:||..::.:.::|      ||:...|    ||:   ||::.
Human  1049 SAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMP----NTL---EGNVT 1106

  Fly  1061 YENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPS 1125
            :..|.|.||||...|:||||:|.:||..|:||||.||.||||.||||.|:|||::|.|.|.|...
Human  1107 FGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEI 1171

  Fly  1126 TEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGY 1190
            ....:..||:.||:|||||:|||.:||||||||:|.| .||.:||:.|||::|||.||.:||..|
Human  1172 KRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSR-VVSQEEIVRAAKEANIHAFIESLPNKY 1235

  Fly  1191 DTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTI 1254
            .|::| |.:||||||||||||||||||.|.||:|||||||||.|||||||:|||:||.||||:.|
Human  1236 STKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVI 1300

  Fly  1255 AHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQ 1298
            ||||:|::|||||.|.:.|.|.|||||.:|:|...||.::..:|
Human  1301 AHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQ 1344

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	276/620 (45%)
		ABC_membrane	116..352	CDD:279056	89/250 (36%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	146/233 (63%)
		MdlB	735..1299	CDD:224055	250/572 (44%)
		ABC_membrane	739..998	CDD:279056	81/259 (31%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	146/239 (61%)
ABCB1	NP_001335874.1	PTZ00265	123..1337	CDD:240339	547/1277 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	207	1.000	Domainoid score	I2881
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG63700
OrthoDB	1	1.010	-	-		D186078at2759
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R932
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.760