Protein Alignment Mdr49 and abcb5

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: XP_031759158.1
• Gene: abcb5 / 394865
• XenbaseID: XB-GENE-5950198
• Length: 1317
• Species: Xenopus tropicalis
• Alignment Length: 1284
• Identity: 528/1284 - (41%)
• Similarity: 759/1284 - (59%)
• Gaps: 82/1284 - (6%)

  Fly    34 LFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFT-SLLVDRTVGVGTSSPAFALPMFGGGQ 97
            :|:::...:.||:::..|.|....:..|...:::||.: |.|...:
 Frog    98 IFQFADWLDIFLMIIGTLGAIGCGSCYPLMNVVFGEMSDSFLCHNS------------------- 143

  Fly    98 QLTNASKEENNQAIIDDATAF-----GIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLE 157
            .|.|:|.....:.|.::...|     |:|..| ....:|.::..:..|:|    |..::||.|..
 Frog   144 SLQNSSACAKFKPIEEEIQKFSLYYAGLGFAV-LFCGYLQVSCWVVAASR----QTRKMRKAFFH 203

  Fly   158 AMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVV 222
            ::|.|:|.|:|.:...:..:::||:::|:.:|||:|:..........|.||:...:.||||.||:
 Frog   204 SVLSQEIGWFDVTKSGDLNTRLTENINKINDGIGDKVAHFFQNTTICVSGILIGLIQGWKLALVI 268

  Fly   223 LSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIP 287
            |:..|.:..|:::.:|:..||..|||.:|:.|..|.:||.|.||||.||.|:|||.:|:.:.|..
 Frog   269 LATSPVLTLASAMFSRIVVSLTTKELAAYAKAGAVAQEVLSSIRTVVAFGGEEKEIKRYTENLKQ 333

  Fly   288 AENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGA 352
            |::.|.||.:.|.....|.....|....:..|||.||:|::.|     ||...::.|.|.|...:
 Frog   334 AKDIGIKKSIASQFALGLVNGAFYATYGVGFWYGTTLVLEDDD-----YTIGDVMAVFFNVSFSS 393

  Fly   353 QNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDV 417
            ..:|.|:.|.||..:|.||..::|.:|.:.|.:|.....|.:|:|..|:|..:.|.|.||:||.|
 Frog   394 YAIGQAASHFEAFHIARAAASSIFKVIKQSSSIDNFSNDGFKPDNIKGNIELKDIYFSYPSRPGV 458

  Fly   418 EILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGV 482
            ::|.||.:.|..|||||.||.|||||||::||:||.|||:.|::.:||.|:::|||.:.|..|||
 Frog   459 KVLNGLNLSVKSGQTVALVGQSGCGKSTIVQLLQRLYDPKEGTLAVDGHDIKSLNVTYYRELIGV 523

  Fly   483 VGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQ 547
            |.||||||.|||.:||||||...|..:||||.:.||.:|||..||..|:|.|||:|||:||||||
 Frog   524 VSQEPVLFGTTIKQNIRYGRDDVTDEEIEKAVKEANAYDFIMALPDKYETLVGERGAQLSGGQKQ 588

  Fly   548 RIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLK 612
            |||:||||||.|::|||||||||||..||..||:||:.|.:|.||:|||||||||..||.||.:.
 Frog   589 RIAVARALVRNPKILLLDEATSALDTGSEAVVQAALDKARKGRTTIVVAHRLSTIWTADVIVVID 653

  Fly   613 DGVVAEQGTHEELMERRGLYCEL-----VSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDE 672
            :|.|||||||.||||::|:|..|     |.::...|.||.::..:........|..:.:.:...:
 Frog   654 NGAVAEQGTHSELMEKKGIYFSLATAQTVQLSDDNETTEKNQNGIIYEKASLIQRFNSQTSLKSK 718

  Fly   673 EDEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRKKKKDKEVVSKVSFTQLMKLNSPEWRFIVV 737
            ..|:||||.|                          .|||   :..|||.||:|||..||.:|::
 Frog   719 ILEDEDEEEE--------------------------SKKD---LPTVSFFQLLKLNRSEWPYILL 754

  Fly   738 GGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTT 802
            |.||:.:.|:..||:.:|:.....:.:..|.:.:|.|....|:||...|::..|..:.:.|||..
 Frog   755 GIIAAGVIGSLLPLFCIFYARIIAVFASNDPETIRKESDLCSLIFGLTGVVILLAYIARGYMFGR 819

  Fly   803 AGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLV 867
            :|..:|.|||..||..:|.||||:|||:.|:.|||.:|||:|.|.:|.|||.|:|.:.:.:..:|
 Frog   820 SGETLTMRLRHMAFKAMIQQDIAWFDDKDNNTGALTTRLATDASEIQTATGYRLGFLAENLIGIV 884

  Fly   868 VGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNG 932
            :.:::.||:.|:..||.|...|.:.:...||...:...|.:.|..::.|.::|.||:.||||:..
 Frog   885 LTVIIAFVYGWELALLGLAMAPFMVICGLLEFSALTGFATRDKKQLQRAGKIATEAVDNIRTLVS 949

  Fly   933 LCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDI 997
            |..||...:.|.:.:.:......||.:..||.||:|.|..:..:.....:|..|:..||:|.|:.
 Frog   950 LTRERTFEEMYSESLQKPYRNSLRKAQIYGLYFAIGHAFYYFTHAALFCFGAYLIKYERINVEEA 1014

  Fly   998 IKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKR-----TSTQPNPPQSPYNTVEKSEG 1057
            :.|...:.||:..||..|.:||:...|..:|..|..||:.     :|:|..  |.|    :...|
 Frog  1015 LLVFSVITFGAMTLGTTLTFAPDYAKATSAARYLFALFESKPAIDSSSQQG--QKP----DCFSG 1073

  Fly  1058 DIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSG 1122
            .:.:.||.|.||||....:|:.|.:.::...|||.||.||.||||.||||.|:|||..|.|.|..
 Frog  1074 SLEFRNVSFNYPTRSDVRVLRDLCVKVESGQTVAFVGSSGCGKSTSVQLLQRFYDPKEGEVLLDD 1138

  Fly  1123 VPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALP 1187
            |.:..|.:..|||::|:|||||||||.:||||||||:|.| .|||.||..|||.:|||:||..||
 Frog  1139 VDAKCFNVQWLRSQMGIVSQEPVLFDCSIAENIAYGDNSR-TVSMDEIQSAAKAANIHSFIEGLP 1202

  Fly  1188 QGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTC 1251
            ..|:|.:| |.:||||||||||||||||:|.||||:|||||||||.|||||||||||:||.||||
 Frog  1203 LKYETLVGAKGTQLSGGQKQRIAIARALIRAPKILLLDEATSALDNESEKVVQQALDQARKGRTC 1267

  Fly  1252 LTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQV 1300
            :.||||||||:|||:|.|:.:|.::|||:|.||:|....|.:|...|.:
 Frog  1268 ILIAHRLTTVQNADIIVVMNKGKIIEHGSHQELLAKCGAYYDLVNAQAI 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	253/609 (42%)
		MdlB	720..1299	CDD:440747	259/584 (44%)
abcb5	XP_031759158.1	PTZ00265	164..1311	CDD:240339	512/1192 (43%)