Protein Alignment Mdr49 and CG10226

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_648040.1
• Gene: CG10226 / 38725
• FlyBaseID: FBgn0035695
• Length: 1320
• Species: Drosophila melanogaster
• Alignment Length: 1309
• Identity: 564/1309 - (43%)
• Similarity: 822/1309 - (62%)
• Gaps: 41/1309 - (3%)

  Fly    16 QLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVG 80
            |.|:.:...|....||.:||||....:..:|:...:.|...|...|..:::|.|..::.::||:|
  Fly    23 QKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLG 87

  Fly    81 VGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIAL 145
            .||||....|.:||||:.|||||.|||.|.:..|:.:|||...:.::.|.......:|..||:||
  Fly    88 QGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLAL 152

  Fly   146 NQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVS 210
            ....|:|:.|.:|.|||:|.|:|.:...|||.::|::::|::.||.|.:...|.::...:|.:|.
  Fly   153 KLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVL 217

  Fly   211 AFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQE 275
            :|:|||||.|.::..:|..:...|.||..||.|..:|..||..|::|||||...||||.||.|:.
  Fly   218 SFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGER 282

  Fly   276 KEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERD----LPDRVY 336
            .|..|:..||.||...|:.||.:||:.:.:...::::..|.:.|||..|||..||    :.:|.|
  Fly   283 SESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSIPIDEREY 347

  Fly   337 TPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGN-RPENTAG 400
            ||||::||:..:|:.|..:...||.:|..|:|..:...:.::|||.|.:||:.:.|. ......|
  Fly   348 TPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKG 412

  Fly   401 HIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDG 465
            .:.|..:.||||||.||.:|:||.|.|..|||||.||.|||||||.|||:||||||..|.|.|||
  Fly   413 AVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDG 477

  Fly   466 RDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGY 530
            .|:|..|:.||||.|.|||||||||..:||||||:|:|.|||.::|.||:|||.||||..|.|||
  Fly   478 EDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGY 542

  Fly   531 DTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVV 595
            ||.:.|||.|:||||:|||||||||::||::|||||||||||..|||.||:||:.|.:|.|||||
  Fly   543 DTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVV 607

  Fly   596 AHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKS 660
            :||||.|.:|.:||::::|...|||||||||:..|.|.::|::....::.|            :.
  Fly   608 SHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAE------------EL 660

  Fly   661 QNLSDEETDDDEEDEEEDEEP-ELQTSGS----SRDSGFRASTRRKRRSQRRKKKKDKEVVSKVS 720
            .|..:|..:..|.....:.|| :|.|..|    .:::.|:........:....::.|...|...:
  Fly   661 LNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSAN 725

  Fly   721 FT----QLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMI 781
            |.    :::....|||.|:::|.|.:.::|.|.|::.:...:.:|.|:...|:.|..:...:::|
  Fly   726 FISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASMAII 790

  Fly   782 FVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCS 846
            .:.||:.||:...:||:.|..|||.:|||:|.:.|..|:.|::.:||.:.||:|||.:||:.|.:
  Fly   791 SLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAA 855

  Fly   847 NVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKA 911
            :||||.|..:..::||....:..:.:.|.:||:..|:.|.|.|.:..|:..|.||..|||.|.|.
  Fly   856 SVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKE 920

  Fly   912 SIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAY 976
            .:||.|::|.|.||.||||.||..|.:::..|.::::|.......::::||||.:||::..|..|
  Fly   921 VLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGY 985

  Fly   977 GISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRT--- 1038
            .:::.|||.:.|:.::.:|.|:|::..:::|.::|.|:||:.|..|.|:|||.|:.::..|.
  Fly   986 AVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQI 1050

  Fly  1039 ------STQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSG 1097
                  ..|.|...:.|.|....:| :.|..:.|.||:|....:||..||.|.:..||||||.||
  Fly  1051 QSPESFEIQQNGNGTAYKTNVVQQG-VSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASG 1114

  Fly  1098 SGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLD--TLRSKLGLVSQEPVLFDRTIAENIAYGNN 1160
            ||||||||||:|||||..|.: |....|....:|  |||.:||:|||||.||:::||:||.||:.
  Fly  1115 SGKSTCVQLLMRYYDPDEGKI-LIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDT 1178

  Fly  1161 FRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILD 1224
            .| .|.||:||||||.:|.|.||.:||..|||.|| |.:|||||||||||||||:|||||||:||
  Fly  1179 SR-QVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLD 1242

  Fly  1225 EATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNK 1289
            |||||||.:||:|||||||.|.|||||:.|||||:|::||::|||::.|.:||.|:|.:|:|.|.
  Fly  1243 EATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNG 1307

  Fly  1290 IYANLYLMQ 1298
            ||:.||..|
  Fly  1308 IYSKLYRCQ 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	282/603 (47%)
		MdlB	720..1299	CDD:440747	261/595 (44%)
CG10226	NP_648040.1	MdlB	147..652	CDD:440747	249/504 (49%)
		MdlB	723..1320	CDD:440747	261/597 (44%)