DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr49 and CG10226

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_648040.1 Gene:CG10226 / 38725 FlyBaseID:FBgn0035695 Length:1320 Species:Drosophila melanogaster


Alignment Length:1309 Identity:564/1309 - (43%)
Similarity:822/1309 - (62%) Gaps:41/1309 - (3%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 QLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVG 80
            |.|:.:...|....||.:||||....:..:|:...:.|...|...|..:::|.|..::.::||:|
  Fly    23 QKKKKTKEKAQPMVSYTELFRYIAGWDYLVLLSGFVAAFLQSLVFPIAIVVYSELVAMFIERTLG 87

  Fly    81 VGTSSPAFALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIAL 145
            .||||....|.:||||:.|||||.|||.|.:..|:.:|||...:.::.|.......:|..||:||
  Fly    88 QGTSSVTIGLSLFGGGKILTNASYEENMQELRKDSVSFGILMTLNTLLMLFSGVYYVDAFNRLAL 152

  Fly   146 NQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVFLIMTFVIGIVS 210
            ....|:|:.|.:|.|||:|.|:|.:...|||.::|::::|::.||.|.:...|.::...:|.:|.
  Fly   153 KLTVRMRREFFKATLRQEIGWHDMAKDQNFAVRITDNMEKIRSGIAENLGHYVEIMCDVIISVVL 217

  Fly   211 AFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSGIRTVFAFSGQE 275
            :|:|||||.|.::..:|..:...|.||..||.|..:|..||..|::|||||...||||.||.|:.
  Fly   218 SFIYGWKLALAIVFYIPLTLVVNSAVAHYQGKLTGQEQSSYVRASSVVEEVIGAIRTVVAFGGER 282

  Fly   276 KEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDERD----LPDRVY 336
            .|..|:..||.||...|:.||.:||:.:.:...::::..|.:.|||..|||..||    :.:|.|
  Fly   283 SESLRYDSLLKPALKAGKWKGAFSGLSDTVMKAMLFITGAGSFWYGANLILYYRDPSIPIDEREY 347

  Fly   337 TPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGN-RPENTAG 400
            ||||::||:..:|:.|..:...||.:|..|:|..:...:.::|||.|.:||:.:.|. ......|
  Fly   348 TPAVVMIVISGIIVSANQISRTSPFLETFAMARGSASAILDVIDRTSLIDPLSKAGKILNYGLKG 412

  Fly   401 HIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDG 465
            .:.|..:.||||||.||.:|:||.|.|..|||||.||.|||||||.|||:||||||..|.|.|||
  Fly   413 AVEFRDVFFRYPAREDVIVLRGLNVVVEEGQTVALVGPSGCGKSTCIQLLQRFYDPVFGQVLLDG 477

  Fly   466 RDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGY 530
            .|:|..|:.||||.|.|||||||||..:||||||:|:|.|||.::|.||:|||.||||..|.|||
  Fly   478 EDVRKYNIKWLRSNIAVVGQEPVLFQGSIGENIRHGKPEATQKEVEDAAKAANAHDFIIALHKGY 542

  Fly   531 DTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVV 595
            ||.:.|||.|:||||:|||||||||::||::|||||||||||..|||.||:||:.|.:|.|||||
  Fly   543 DTDISEKGVQLSGGQRQRIAIARALIQQPKILLLDEATSALDYHSEKLVQAALDKACKGRTTLVV 607

  Fly   596 AHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKS 660
            :||||.|.:|.:||::::|...|||||||||:..|.|.::|::....::.|            :.
  Fly   608 SHRLSAIRHAHRIVYIENGKAVEQGTHEELMKLEGFYHKMVTVHSYDDSAE------------EL 660

  Fly   661 QNLSDEETDDDEEDEEEDEEP-ELQTSGS----SRDSGFRASTRRKRRSQRRKKKKDKEVVSKVS 720
            .|..:|..:..|.....:.|| :|.|..|    .:::.|:........:....::.|...|...:
  Fly   661 LNELEEVAEIKERKMSYEVEPYQLGTRNSIVSLEKNAEFQMKNLNGLANITMNQEIDDPRVPSAN 725

  Fly   721 FT----QLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMI 781
            |.    :::....|||.|:::|.|.:.::|.|.|::.:...:.:|.|:...|:.|..:...:::|
  Fly   726 FISTFFRILGWARPEWSFLIIGAICAGLYGVTMPVFSVVLAELYGSLAKPTDEEVLEQSASMAII 790

  Fly   782 FVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCS 846
            .:.||:.||:...:||:.|..|||.:|||:|.:.|..|:.|::.:||.:.||:|||.:||:.|.:
  Fly   791 SLVIGIAAGVVCYIQTFFFNLAGVWLTTRMRSKTFRCIMNQEMGWFDRKENSIGALSARLSGDAA 855

  Fly   847 NVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKA 911
            :||||.|..:..::||....:..:.:.|.:||:..|:.|.|.|.:..|:..|.||..|||.|.|.
  Fly   856 SVQGAIGFPLSNIIQAFTNFICSIAIAFPYSWELALICLSTSPFMVASIVFEARFGEKSALKEKE 920

  Fly   912 SIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAY 976
            .:||.|::|.|.||.||||.||..|.:::..|.::::|.......::::||||.:||::..|..|
  Fly   921 VLEETSRIATETITQIRTVAGLRREEELIKIYDKEVERYRHQILSRLKWRGLVNSLGKSLMFFGY 985

  Fly   977 GISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRT--- 1038
            .:::.|||.:.|:.::.:|.|:|::..:::|.::|.|:||:.|..|.|:|||.|:.::..|.   
  Fly   986 AVTLTYGGHMCADGKIKFETIMKISNTMLYGLFILAQSLAFTPAFNAALLSANRMYEIIDRKPQI 1050

  Fly  1039 ------STQPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSG 1097
                  ..|.|...:.|.|....:| :.|..:.|.||:|....:||..||.|.:..||||||.||
  Fly  1051 QSPESFEIQQNGNGTAYKTNVVQQG-VSYRGLNFSYPSRPHIKVLQNFNLDINQGQTVALVGASG 1114

  Fly  1098 SGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLD--TLRSKLGLVSQEPVLFDRTIAENIAYGNN 1160
            ||||||||||:|||||..|.: |....|....:|  |||.:||:|||||.||:::||:||.||:.
  Fly  1115 SGKSTCVQLLMRYYDPDEGKI-LIDQESIHHDMDLKTLRRRLGIVSQEPSLFEKSIADNIGYGDT 1178

  Fly  1161 FRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILILD 1224
            .| .|.||:||||||.:|.|.||.:||..|||.|| |.:|||||||||||||||:|||||||:||
  Fly  1179 SR-QVPMQQIIEAAKMANAHEFIMSLPAQYDTVLGSKGTQLSGGQKQRIAIARAMVRNPKILLLD 1242

  Fly  1225 EATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMALNK 1289
            |||||||.:||:|||||||.|.|||||:.|||||:|::||::|||::.|.:||.|:|.:|:|.|.
  Fly  1243 EATSALDFQSERVVQQALDSACSGRTCIVIAHRLSTIQNANVICVIQAGKIVEQGSHSQLLAKNG 1307

  Fly  1290 IYANLYLMQ 1298
            ||:.||..|
  Fly  1308 IYSKLYRCQ 1316

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 286/610 (47%)
ABC_membrane 116..352 CDD:279056 89/239 (37%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 150/233 (64%)
MdlB 735..1299 CDD:224055 256/576 (44%)
ABC_membrane 739..998 CDD:279056 88/258 (34%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 146/241 (61%)
CG10226NP_648040.1 PTZ00265 81..1311 CDD:240339 546/1244 (44%)
ABC_membrane <147..333 CDD:279056 71/185 (38%)
ABC_MTABC3_MDL1_MDL2 414..649 CDD:213216 150/234 (64%)
ABC_membrane 749..1019 CDD:279056 91/269 (34%)
ABC_MTABC3_MDL1_MDL2 1076..1316 CDD:213216 146/241 (61%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 162 1.000 Domainoid score I1247
eggNOG 1 0.900 - - E2759_KOG0055
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 156 1.000 Inparanoid score I209
Isobase 1 0.950 - 0 Normalized mean entropy S2081
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - mtm951
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - P PTHR24221
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X92
1110.820

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