Protein Alignment Mdr49 and ABCB7

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_728642.2
• Gene: ABCB7 / 38193
• FlyBaseID: FBgn0035244
• Length: 743
• Species: Drosophila melanogaster
• Alignment Length: 590
• Identity: 179/590 - (30%)
• Similarity: 293/590 - (49%)
• Gaps: 54/590 - (9%)

  Fly    74 LVDRTVGV------GTSSPAFALPMF--GGGQQLTNASKEENNQAIIDDATA--FGIGSLVGSVA 128
            ||.:.||:      |:......:|..  |....:|..:.:....|::..|||  .|.|....|.|
  Fly   153 LVRKRVGISLGLLAGSKLLTVCVPFLFKGAVDTMTTLNMDTAPDAVLSAATALMLGYGIARASAA 217

  Fly   129 MFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWY-DTSSGSNFASKMTEDLDKLKEGIGE 192
            .|..:..|:  ..::|.:.|.:|.......:...|:|:: :..:|:     :::.:|:...||..
  Fly   218 GFNELRNAV--FAKVAHHSIRKIASNVFLHLHNLDLAFHLNKQTGA-----LSKTIDRGSRGINF 275

  Fly   193 KIVIVVFLIM--TFVIGIVSAFVYGWKLTL----VVLSCVPFIIAATSVVARLQGSLAEKELKSY 251
            .:..:||.|:  .|.:.:||: :.|.|..|    |.:.||....|.|..|.:.:........::.
  Fly   276 VLSAMVFNIVPTIFELALVSS-ILGVKCGLAFAGVSMGCVGIYAAYTLSVTQWRTQFRVFMNQAE 339

  Fly   252 SDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAE----NTGRKKGLYSGMGNALSWLIIYL 312
            ::|.|...:......||..|:.::.|...:.::|...|    .|.....|.:...||:....:.|
  Fly   340 NEAGNKAVDSLINYETVKYFNNEKYEAGCYNEVLKKYEAASLKTSSSLALLNFGQNAIFSSALSL 404

  Fly   313 CMALAIWYGVTLILDERDLPDRVYTPAVLVIV---LFAVIMGAQNLGFASPHVEAIAVATAAGQT 374
            .|.||          .:::.....|...||:|   ||.:.:....||.....|....:...|..|
  Fly   405 IMVLA----------AKEIAQGNMTVGDLVMVNALLFQLSIPLGFLGSVYREVRQALLDMRAMFT 459

  Fly   375 LFNI---IDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRY-PARPDVEILKGLTVDVLPGQTVAF 435
            |.|:   |...:...|:     ..:.|...|.|..:.|.| |.:|   |.:.|:..:..|:.||.
  Fly   460 LMNVDSSIQTAANAQPL-----FVDTTNSSIEFRNVSFEYEPGKP---IFRDLSFTIPAGKNVAI 516

  Fly   436 VGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRY 500
            ||.||.|||::::|:.||::|.:|.|.:.|:|:..:::..||..|.||.|:.|||..||..||.|
  Fly   517 VGGSGSGKSSMVRLLFRFFEPNSGKVLIGGQDISAVDLESLRKVIAVVPQDSVLFHNTIEHNIHY 581

  Fly   501 GRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLD 565
            |..|.:.|:::.|||.|:.||.|...|..|.|||||:|.::|||:|||:|||||:::...:|:.|
  Fly   582 GNLSKSHAEVQNAARMADLHDSIMSWPGQYSTQVGERGLKLSGGEKQRVAIARAILKNTPILIFD 646

  Fly   566 EATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRG 630
            ||||:||..:|..:..||..|:.|.|::.:||||||:.:||:|:.|::|.|.|:|||.||:.:.|
  Fly   647 EATSSLDSITEHNILQALTRATSGRTSICIAHRLSTVKDADEILVLENGRVGERGTHSELLRQNG 711

  Fly   631 LYCEL 635
            ||..|
  Fly   712 LYARL 716

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	179/590 (30%)
		ABC_membrane	116..352	CDD:279056	54/251 (22%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	105/235 (45%)
		MdlB	735..1299	CDD:224055
		ABC_membrane	739..998	CDD:279056
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216
ABCB7	NP_728642.2	ABC_membrane	164..437	CDD:294371	60/290 (21%)
		ATM1	222..717	CDD:227590	162/521 (31%)
		P-loop_NTPase	485..720	CDD:304359	105/235 (45%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24221
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.010