Protein Alignment Mdr49 and Mdr50

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_523740.3
• Gene: Mdr50 / 36582
• FlyBaseID: FBgn0010241
• Length: 1313
• Species: Drosophila melanogaster
• Alignment Length: 1311
• Identity: 559/1311 - (42%)
• Similarity: 813/1311 - (62%)
• Gaps: 62/1311 - (4%)

  Fly     4 KEESRLPQAGDFQLKEGSVV-DATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIY 67
            |::|:..::.....::||.. :..::.|||.||||:|:.:|.|.|:.||.|.|.....|...:|:
  Fly    45 KKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIF 109

  Fly    68 GEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEEN--NQAIIDDATAFGIGSLVGSVAMF 130
            |...:.::|                .||..:...:.:.::  :..::|....|.:.:....:.|.
  Fly   110 GNLANDMID----------------LGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIML 158

  Fly   131 LLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIV 195
            :...|:|...|..|.:||..||..|..::|.||:.|||.:.....||:|.|||.|:::|:.||:|
  Fly   159 VCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVV 223

  Fly   196 IVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEE 260
            :.|..::.||..:|.|||.||:|:||.|:.:|....|..:||.....||:||:..|:.||.|.|.
  Fly   224 MFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEG 288

  Fly   261 VFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLI 325
            ..||||||.||.|:.||...:.:.::.|:....|:.::||:|..|.|..||...|||.||||.|:
  Fly   289 ALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLV 353

  Fly   326 LDERDLPD-RVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMD 389
            :.....|. ..|....::.|.|:|:||:.|:|.|:|::||..:|..|...:|:||::..:::|:|
  Fly   354 IKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPID 418

  Fly   390 EKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFY 454
            .:|.:.......|.|:.:.|:||.||:|.||..|.:.:..|||||.||.|||||||.|||:||||
  Fly   419 GEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFY 483

  Fly   455 DPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANC 519
            ||:||::..:|.:|:.|::.||||:||||||||:||||:|.|||||||..||:.:||.||.|||.
  Fly   484 DPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANA 548

  Fly   520 HDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALE 584
            ..||.:|||||||.|||:|||:||||||||||||||:|.|::|||||||||||..||.:||:|||
  Fly   549 AIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALE 613

  Fly   585 LASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADE 649
            ..|.|.||::|||||||:..||:||.:..|.|.|.|||:||||.:..|..||: ||..|    |:
  Fly   614 KVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVT-TQLGE----DD 673

  Fly   650 GAVAG--RPLQKSQNLSDEETDDDEE----DEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRK 708
            |:|..  ..:.|:.::.||   |:||    .|:|||:..:              |..|.:.:::|
  Fly   674 GSVLSPTGDIYKNFDIKDE---DEEEIKVLSEDEDEDVMV--------------TDEKNKKKKKK 721

  Fly   709 KKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDD-VVR 772
            |.||...|..:  .::||:|.|||..|.||.|:||:.|...|::.:.||....|||..|:| .||
  Fly   722 KVKDPNEVKPM--LEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVR 784

  Fly   773 AEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGAL 837
            ....:.|:.|:..|::.|:...||.|.|..||.::|.|||...|..::.|::|:|||:.|..|:|
  Fly   785 ENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSL 849

  Fly   838 CSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFI 902
            |:||:.|.:.||||||.|:||::|:::||.:|:.:...:.|...|:.|...|.:.::.|::...:
  Fly   850 CARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLM 914

  Fly   903 MKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYV-QQIDRVDIACRRKVRFRGLVFA 966
            .|....:..::|..:::|||.::|||||..|..|......|: ..|..|:|: :|...|||||:.
  Fly   915 AKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEIS-KRNTHFRGLVYG 978

  Fly   967 LGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRL 1031
            |.::..|.||...||||...|....:.:.|:.||::|||.|:..:..|||:|||:...:.:|..:
  Fly   979 LARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTI 1043

  Fly  1032 MDLFKRTST---QPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALV 1093
            ....:|..:   :|...:.|::    |||.:.::.|.|.||||....:|:||.|.:.|...:|||
  Fly  1044 FTFLRRQPSIVDRPGVSRDPWH----SEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALV 1104

  Fly  1094 GPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYG 1158
            ||||.|||||:||:.|:||...|:..:.........:..||::||:|||||:||||||.|||:||
  Fly  1105 GPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYG 1169

  Fly  1159 NNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILI 1222
            :|.| :|:.||||.|.||||||.||:.||.|||||:| |.:||||||||||||||||:|||||::
  Fly  1170 DNAR-NVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIML 1233

  Fly  1223 LDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMAL 1287
            |||||||||.|||||||.|||.|..|||.::|||||:||.::|:|.|.:.|:|.|.|.|.:|:|.
  Fly  1234 LDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLAN 1298

  Fly  1288 NKIYANLYLMQ 1298
            ..:|..||.:|
  Fly  1299 RGLYYTLYKLQ 1309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	267/601 (44%)
		MdlB	720..1299	CDD:440747	258/585 (44%)
Mdr50	NP_523740.3	PTZ00265	69..1308	CDD:240339	554/1284 (43%)