DRSC/TRiP Functional Genomics Resources

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Protein Alignment Mdr49 and Mdr50

DIOPT Version :9

Sequence 1:NP_523724.2 Gene:Mdr49 / 36428 FlyBaseID:FBgn0004512 Length:1302 Species:Drosophila melanogaster
Sequence 2:NP_523740.3 Gene:Mdr50 / 36582 FlyBaseID:FBgn0010241 Length:1313 Species:Drosophila melanogaster


Alignment Length:1311 Identity:559/1311 - (42%)
Similarity:813/1311 - (62%) Gaps:62/1311 - (4%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 KEESRLPQAGDFQLKEGSVV-DATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIY 67
            |::|:..::.....::||.. :..::.|||.||||:|:.:|.|.|:.||.|.|.....|...:|:
  Fly    45 KKKSKHDESDASDEEDGSQYHEDVKQVSYFQLFRYATKKDRALYVIGLLSAVATGLTTPANSLIF 109

  Fly    68 GEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEEN--NQAIIDDATAFGIGSLVGSVAMF 130
            |...:.::|                .||..:...:.:.::  :..::|....|.:.:....:.|.
  Fly   110 GNLANDMID----------------LGGLLESGKSYRADDAISTLLLDKVRQFSLQNTYIGIIML 158

  Fly   131 LLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIV 195
            :...|:|...|..|.:||..||..|..::|.||:.|||.:.....||:|.|||.|:::|:.||:|
  Fly   159 VCSYLSITCFNYAAHSQILTIRSKFFRSILHQDMKWYDFNQSGEVASRMNEDLSKMEDGLAEKVV 223

  Fly   196 IVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEE 260
            :.|..::.||..:|.|||.||:|:||.|:.:|....|..:||.....||:||:..|:.||.|.|.
  Fly   224 MFVHYLVAFVGSLVLAFVKGWQLSLVCLTSLPLTFIAMGLVAVATSRLAKKEVTMYAGAAVVAEG 288

  Fly   261 VFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLI 325
            ..||||||.||.|:.||...:.:.::.|:....|:.::||:|..|.|..||...|||.||||.|:
  Fly   289 ALSGIRTVKAFEGEAKEVAAYKERVVAAKILNIKRNMFSGIGFGLLWFFIYASYALAFWYGVGLV 353

  Fly   326 LDERDLPD-RVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMD 389
            :.....|. ..|....::.|.|:|:||:.|:|.|:|::||..:|..|...:|:||::..:::|:|
  Fly   354 IKGYHEPAYENYDAGTMITVFFSVMMGSMNIGMAAPYIEAFGIAKGACAKVFHIIEQIPEINPID 418

  Fly   390 EKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFY 454
            .:|.:.......|.|:.:.|:||.||:|.||..|.:.:..|||||.||.|||||||.|||:||||
  Fly   419 GEGKKLNEPLTTIEFKEVEFQYPTRPEVSILNKLNLKIHRGQTVALVGPSGCGKSTCIQLVQRFY 483

  Fly   455 DPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANC 519
            ||:||::..:|.:|:.|::.||||:||||||||:||||:|.|||||||..||:.:||.||.|||.
  Fly   484 DPQAGNLLFNGTNLKDLDINWLRSRIGVVGQEPILFATSIYENIRYGREDATREEIEAAAAAANA 548

  Fly   520 HDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALE 584
            ..||.:|||||||.|||:|||:||||||||||||||:|.|::|||||||||||..||.:||:|||
  Fly   549 AIFIKKLPKGYDTLVGERGAQLSGGQKQRIAIARALIRDPEILLLDEATSALDTASEAKVQAALE 613

  Fly   585 LASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADE 649
            ..|.|.||::|||||||:..||:||.:..|.|.|.|||:||||.:..|..||: ||..|    |:
  Fly   614 KVSAGRTTIIVAHRLSTVRRADRIVVINKGEVVESGTHQELMELKDHYFNLVT-TQLGE----DD 673

  Fly   650 GAVAG--RPLQKSQNLSDEETDDDEE----DEEEDEEPELQTSGSSRDSGFRASTRRKRRSQRRK 708
            |:|..  ..:.|:.::.||   |:||    .|:|||:..:              |..|.:.:::|
  Fly   674 GSVLSPTGDIYKNFDIKDE---DEEEIKVLSEDEDEDVMV--------------TDEKNKKKKKK 721

  Fly   709 KKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDD-VVR 772
            |.||...|..:  .::||:|.|||..|.||.|:||:.|...|::.:.||....|||..|:| .||
  Fly   722 KVKDPNEVKPM--LEVMKMNKPEWLQIAVGCISSVIMGCAMPIFAVLFGSILQILSVKDNDQYVR 784

  Fly   773 AEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGAL 837
            ....:.|:.|:..|::.|:...||.|.|..||.::|.|||...|..::.|::|:|||:.|..|:|
  Fly   785 ENSNQYSLYFLIAGIVVGIATFLQIYFFGIAGERLTERLRGLMFEAMLRQEVAWFDDKANGTGSL 849

  Fly   838 CSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFI 902
            |:||:.|.:.||||||.|:||::|:::||.:|:.:...:.|...|:.|...|.:.::.|::...:
  Fly   850 CARLSGDAAAVQGATGQRIGTIVQSISTLALGIALSMYYEWSLGLVALAFTPFILIAFYMQRTLM 914

  Fly   903 MKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYV-QQIDRVDIACRRKVRFRGLVFA 966
            .|....:..::|..:::|||.::|||||..|..|......|: ..|..|:|: :|...|||||:.
  Fly   915 AKENMGSAKTMENCTKLAVEVVSNIRTVASLGREEMFHQNYIGMLIPAVEIS-KRNTHFRGLVYG 978

  Fly   967 LGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRL 1031
            |.::..|.||...||||...|....:.:.|:.||::|||.|:..:..|||:|||:...:.:|..:
  Fly   979 LARSLMFFAYAACMYYGTWCVIHRGILFGDVFKVSQALIMGTASIANALAFAPNMQKGVSAAKTI 1043

  Fly  1032 MDLFKRTST---QPNPPQSPYNTVEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALV 1093
            ....:|..:   :|...:.|::    |||.:.::.|.|.||||....:|:||.|.:.|...:|||
  Fly  1044 FTFLRRQPSIVDRPGVSRDPWH----SEGYVRFDKVKFSYPTRSEIQVLKGLELAVSKGQKIALV 1104

  Fly  1094 GPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYG 1158
            ||||.|||||:||:.|:||...|:..:.........:..||::||:|||||:||||||.|||:||
  Fly  1105 GPSGCGKSTCIQLIQRFYDVDEGATLIDECDVRNVSMTNLRNQLGIVSQEPILFDRTIRENISYG 1169

  Fly  1159 NNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILI 1222
            :|.| :|:.||||.|.||||||.||:.||.|||||:| |.:||||||||||||||||:|||||::
  Fly  1170 DNAR-NVTDQEIISACKKSNIHEFIANLPLGYDTRMGEKGAQLSGGQKQRIAIARALIRNPKIML 1233

  Fly  1223 LDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMAL 1287
            |||||||||.|||||||.|||.|..|||.::|||||:||.::|:|.|.:.|:|.|.|.|.:|:|.
  Fly  1234 LDEATSALDAESEKVVQDALDAASEGRTTISIAHRLSTVVHSDVIFVFENGLVCEAGDHKQLLAN 1298

  Fly  1288 NKIYANLYLMQ 1298
            ..:|..||.:|
  Fly  1299 RGLYYTLYKLQ 1309

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Mdr49NP_523724.2 MdlB 34..640 CDD:224055 271/608 (45%)
ABC_membrane 116..352 CDD:279056 88/236 (37%)
ABC_MTABC3_MDL1_MDL2 402..636 CDD:213216 147/233 (63%)
MdlB 735..1299 CDD:224055 252/570 (44%)
ABC_membrane 739..998 CDD:279056 91/260 (35%)
ABC_MTABC3_MDL1_MDL2 1059..1298 CDD:213216 138/239 (58%)
Mdr50NP_523740.3 PTZ00265 69..1308 CDD:240339 554/1284 (43%)
ABC_membrane 92..382 CDD:279056 100/305 (33%)
ABC_MTABC3_MDL1_MDL2 431..668 CDD:213216 149/237 (63%)
ABC_membrane 750..1020 CDD:279056 96/270 (36%)
ABC_MTABC3_MDL1_MDL2 1070..1309 CDD:213216 138/239 (58%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 191 1.000 Domainoid score I1905
eggNOG 1 0.900 - - E2759_KOG0055
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 876 1.000 Inparanoid score I60
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG63700
OrthoDB 1 1.010 - - D186078at2759
OrthoFinder 1 1.000 - - FOG0000106
OrthoInspector 1 1.000 - - mtm951
orthoMCL 1 0.900 - - OOG6_100059
Panther 1 1.100 - - P PTHR24221
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R932
SonicParanoid 1 1.000 - - X92
1211.910

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