Protein Alignment Mdr49 and Abcb8

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001007797.1
• Gene: Abcb8 / 362302
• RGDID: 1307655
• Length: 714
• Species: Rattus norvegicus
• Alignment Length: 642
• Identity: 227/642 - (35%)
• Similarity: 340/642 - (52%)
• Gaps: 88/642 - (13%)

  Fly    45 LLVVSLLVATAASAFIPYFMIIYGEFTSLLVDRTVGVGTSSPAFALPMFGGGQQLTNASKEENNQ 109
            |.:|..|.|...:..||   ::.|:...::...|                  ::...:...|:.:
  Rat   132 LAIVLALGAALVNVQIP---LLLGQLVEIVAKYT------------------REHVGSFVSESRR 175

  Fly   110 AIIDDATAFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSN 174
            ..|.....:|:..|:    .|..:.|...:..|:|::    :||....::||||||::|......
  Rat   176 LSIQLLLLYGVQGLL----TFGYLVLLSHMGERMAMD----MRKALFSSLLRQDIAFFDAKKTGQ 232

  Fly   175 FASKMTEDLDKLKEGIGEKIVIVVFL-IMTFVIG-IVSAFVYGWKLTLVVLSCVPFIIAATSVVA 237
            ..|::|.|:.:.|...  |:||...| ..|.||| :::..:...:|||::....|.::.    |.
  Rat   233 LVSRLTTDVQEFKSSF--KLVISQGLRSSTQVIGSLMTLSILSPRLTLMLAVVTPALMG----VG 291

  Fly   238 RLQGS----LAEKELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLL----IPAENTGRK 294
            .|.||    |:.:..:..:.|..|.:|....:|||.||:.:::|:||:...|    ..||..||.
  Rat   292 TLMGSGLRKLSRQCQEQIARATGVADEALGSVRTVRAFAMEKREEERYQAELESCCCKAEELGRG 356

  Fly   295 KGLYSGMGNALSWLIIYLCMAL-AIWYGVTLILDER----DL------PDRVYTPAVLVIVLFA- 347
            ..|:.|:.|     |.:.||.| .::.|.:|:..::    ||      ...|......:.|||.
  Rat   357 IALFQGLSN-----IAFNCMVLGTLFIGGSLVAGQQLKGGDLMSFLVASQTVQRSMASLSVLFGQ 416

  Fly   348 VIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNRP-ENTAGHIRFEGIRFRY 411
            |:.|                 .:||..:|..:.. |.|.|:....:.| ::..|.|.|:.:.|.|
  Rat   417 VVRG-----------------LSAGARVFEYMSL-SPVIPLTGGYSIPSKDLRGSITFQNVSFSY 463

  Fly   412 PARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWL 476
            |.||...:||..|:.:.||:.||.||.||.||:|:..|::|||||.||.|.|||.|||||:..||
  Rat   464 PCRPGFNVLKNFTLKLPPGKIVALVGQSGGGKTTVASLLERFYDPTAGVVTLDGHDLRTLDPSWL 528

  Fly   477 RSQ-IGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQ 540
            |.| ||.:.||||||||||.||||:|:..|:..::..|||.||.|:||:..|.||.|.|||:|..
  Rat   529 RGQVIGFISQEPVLFATTIMENIRFGKLDASDEEVYTAARKANAHEFISSFPDGYSTVVGERGTT 593

  Fly   541 ISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNA 605
            :|||||||:||||||:::|.||:|||||||||..||:.||.||:.||.|.|.||:||||||:..|
  Rat   594 LSGGQKQRLAIARALIKRPTVLILDEATSALDAESERIVQEALDRASAGRTVLVIAHRLSTVRAA 658

  Fly   606 DKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAGRPLQKSQN 662
            ..|:.:.:|.|.|.||||||:::.|||.||:    |::|.:|  ...:..|.:|.::
  Rat   659 HSIIVMANGQVCEAGTHEELLQKGGLYAELI----RRQALDA--SLPSAPPAEKPED 709

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	223/621 (36%)
		MdlB	720..1299	CDD:440747
Abcb8	NP_001007797.1	MdlB	116..696	CDD:440747	224/625 (36%)