Protein Alignment Mdr49 and Abcb10

DIOPT Version :9

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_001012166.1
• Gene: Abcb10 / 361439
• RGDID: 1311222
• Length: 715
• Species: Rattus norvegicus
• Alignment Length: 629
• Identity: 226/629 - (35%)
• Similarity: 343/629 - (54%)
• Gaps: 70/629 - (11%)

  Fly   704 SQRRKKKKDKEVVSKVSFTQLMKLNSPE-------WRFIVVGGIASVMHGATFPLWGLFFGDFFG 761
            ||||.....:..|.|     |:.|..||       ..|:.|..:.::  .|.|     |.|....
  Rat   110 SQRRPATTGRSEVWK-----LLGLVRPERGRLSAAVGFLAVSSVITM--SAPF-----FLGKIID 162

  Fly   762 IL-----SDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIG 821
            ::     .|..|.:.|. ...::.:|    |.....|.::.|:..::|..:..|||...|.:|:.
  Rat   163 VIYTNPTEDFGDSLTRL-CAGLTCVF----LCGAAANSIRVYLMQSSGQSIVNRLRTSLFSSILR 222

  Fly   822 QDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLV 886
            |::|:||..|  .|.|.:||:||.:.:..:....:...|:|||...||  ||.:|....:|.|.|
  Rat   223 QEVAFFDKTR--TGELINRLSSDTALLGHSVTENLSDGLRAVAQASVG--VGMMFFVSPSLATFV 283

  Fly   887 --TLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDR 949
              .:|.:.:...:.||::.|.::..:.|:.||:|:|.|.|.||||:.....|...:::|..::|:
  Rat   284 LSVVPPISVLAVIYGRYLRKLSKATQDSLAEATQLAEERIGNIRTIRAFGKEMTEVEKYTSRVDQ 348

  Fly   950 VDIACRRKVRFRGLVFALGQAAPFLAYGIS--------MYYGGILVAEERMNYEDIIKVAEALIF 1006
            :....|::        ||.:|..|.|.|:|        :|.||:|:....|.   :.:::..|::
  Rat   349 LLQLARKE--------ALARAGFFGAAGLSGNLIVLSVLYKGGLLLGSTHMT---VGELSSFLMY 402

  Fly  1007 GSWM---LGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYN----TVEKS-EGDIVYEN 1063
            ..|:   :|...::...:...:.:.|||.:|.:|      .|:.|:|    ..||: :|.:.:.|
  Rat   403 AFWVGLSIGGLSSFYSQLMKGLGAGGRLWELLER------QPRLPFNEGIVLDEKTFQGALEFRN 461

  Fly  1064 VGFEYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEF 1128
            |.|.||.|....:.|..:|:|...:..||||||||||||.|.||||.|||.||:|:|.|....:.
  Rat   462 VHFTYPARPEVSVFQDFSLSIPSGSVTALVGPSGSGKSTVVSLLLRLYDPSSGTVSLDGHDIRQL 526

  Fly  1129 PLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTR 1193
            ....||||:|.||||||||..::|||||||.:....|:.:::..||:.:|...||.:.|||:||.
  Rat   527 NPVWLRSKIGTVSQEPVLFSCSVAENIAYGADNLSSVTARQVERAAEVANAAEFIRSFPQGFDTV 591

  Fly  1194 LG-KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHR 1257
            :| |...|||||||||||||||::|||||:|||||||||.|:|.:||:|||....|||.|.||||
  Rat   592 VGEKGVLLSGGQKQRIAIARALLKNPKILLLDEATSALDAENEHLVQEALDRLMEGRTVLIIAHR 656

  Fly  1258 LTTVRNADLICVLKRGVVVEHGTHDELMAL-NKIYANLYLMQQV 1300
            |:|::||:.:.||.:|.:.|||||:||:.. |.:|..|...|.:
  Rat   657 LSTIKNANFVAVLNQGKICEHGTHEELLLKPNGLYRKLMNKQSL 700

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055
		ABC_membrane	116..352	CDD:279056
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216
		MdlB	735..1299	CDD:224055	214/588 (36%)
		ABC_membrane	739..998	CDD:279056	71/273 (26%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	128/240 (53%)
Abcb10	NP_001012166.1	3a01208	10..694	CDD:273363	224/621 (36%)
		ABC_membrane	142..403	CDD:279056	74/287 (26%)
		ABC_MTABC3_MDL1_MDL2	458..698	CDD:213216	128/239 (54%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	1	1.100	-	-	O	PTHR24221
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910