DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and Abcb11

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001350421.1	Gene:	Abcb11 / 27413	MGIID:	1351619	Length:	1321	Species:	Mus musculus

Alignment Length:	1336	Identity:	509/1336 - (38%)
Similarity:	775/1336 - (58%)	Gaps:	94/1336 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 EESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGE 69
            ::|||.   |.:..||:      :..:|:|||:|:..:.:|:.:..:.|.......|..:|::|.
Mouse    30 KKSRLQ---DKKKGEGA------RVGFFELFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGI 85

  Fly    70 FTSLLVDRTVGVGTSSPAFALP--------------MFGGGQQLTNASK----EENNQAIIDDAT 116
            .|.:.|:..:    .....::|              .|  .|.:||.:.    :.|::.|.....
Mouse    86 LTDIFVEYDI----ERQELSIPEKVCMNNTIVWINSSF--NQNMTNGTSCGLVDINSEVIKFSGI 144

  Fly   117 AFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTE 181
            ..|:|     ||:.:|....|.|.......||.::||.:...::|.:|.|:|.:|.....|:.::
Mouse   145 YAGVG-----VAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDCTSVGELNSRFSD 204

  Fly   182 DLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEK 246
            |::|:.|.|.:::.:.:..:.|.:.|::..|..|||||||:|:..|.|....:|:........|.
Mouse   205 DINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTEL 269

  Fly   247 ELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIY 311
            |||:|:.|.::.:||.|.||||.||.|:.||.||:.|.|:.|:..|..||:..|......|.:|:
Mouse   270 ELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIF 334

  Fly   312 LCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLF 376
            .|.|||.|||..|:|||.:     |||..|:.:...||:.|.|:|.||..:|..:...:|..::|
Mouse   335 FCYALAFWYGSRLVLDEGE-----YTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIF 394

  Fly   377 NIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGC 441
            ..|||...:|.|...|.:.:...|.|.|..:.|.||:||:|:||..|::.:.||:|.||||:||.
Mouse   395 QTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGA 459

  Fly   442 GKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSAT 506
            ||||.:||:||||||..|.|.|||.|:|:||:.|||.|||:|.||||||:|||.||||.||..||
Mouse   460 GKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGREEAT 524

  Fly   507 QADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSAL 571
            ..||.:||:.||.::||..||:.:||.|||.|.|:|||||||:||||||:|:|::||||.|||||
Mouse   525 MEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMATSAL 589

  Fly   572 DPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELV 636
            |..||.:||.||.....|.|.:.|||||||:.:||.|:..:.|...|:||||||:||:|:|..||
Mouse   590 DNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGVYFMLV 654

  Fly   637 SITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRK 701
            ::..:::.|..:.| :.|:                  |..|.:.||...|..|.....|||.|::
Mouse   655 TLQSQEDNTHKETG-IKGK------------------DTTEGDTPERTFSRGSYQDSLRASIRQR 700

  Fly   702 RRSQ-----------------RRKKKKDKEV----VSKVSFTQLMKLNSPEWRFIVVGGIASVMH 745
            .:||                 ..:.:||.:|    |......:::|.|..||.:|:||.:.:.::
Mouse   701 SKSQLSHLSHEPPLAIGDHKSSYEDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAIN 765

  Fly   746 GATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTR 810
            ||..|::.|.|.......|..|.:..|:|:..:.:.||.:|.::.....||.|.|..:|..:|.|
Mouse   766 GAVTPIYSLLFSQILKTFSLVDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKR 830

  Fly   811 LRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFV 875
            |||..|..::.|||.:|||.:|:.|.|.:|||:|.|.||||||::||.|:.:...:.|.:::.|:
Mouse   831 LRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFL 895

  Fly   876 FSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVL 940
            |:|:.:|:..|..|.:.||..::.:.:...|.:.|..:|:|.|:..||::|||||.|:.:|.:.:
Mouse   896 FNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFI 960

  Fly   941 DQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALI 1005
            ..:..::::......||....||.:|..|...|||...:..|||.|:..|.:|:..:.:|..::.
Mouse   961 KAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNFSYVFRVVSSIA 1025

  Fly  1006 FGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTV----EKSEGDIVYENVGF 1066
            ..:..:|:..:|.|:...|.:||.|...|..|     .||...|:..    :..:|.|.:.:..|
Mouse  1026 MSATAVGRTFSYTPSYAKAKISAARFFQLLDR-----KPPIDVYSGAGEKWDNFQGKIDFIDCKF 1085

  Fly  1067 EYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLD 1131
            .||:|....:|.||::::....|:|.||.||.||||.:|||.|:|||..|:|.:.|..|.:..:.
Mouse  1086 TYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQ 1150

  Fly  1132 TLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG- 1195
            .|||.:|:|||||||||.:|.:||.||:|.: ::|::..|.|||::.:|:|:.:||:.|:|.:|
Mouse  1151 FLRSNIGIVSQEPVLFDCSIMDNIKYGDNTK-EISVERAIAAAKQAQLHDFVMSLPEKYETNVGI 1214

  Fly  1196 KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTT 1260
            :.||||.|:|||||||||:||:||||:|||||||||.||||.||.|||:||.||||:.|||||:|
Mouse  1215 QGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLST 1279

  Fly  1261 VRNADLICVLKRGVVVEHGTHDELMALNKIYANLYL 1296
            ::|:|:|.|:.:|||:|.|||.:||.....|..|.:
Mouse  1280 IQNSDIIAVMSQGVVIEKGTHKKLMDQKGAYYKLVI 1315

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	253/623 (41%)
		ABC_membrane	116..352	CDD:279056	81/235 (34%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	137/233 (59%)
		MdlB	735..1299	CDD:224055	226/567 (40%)
		ABC_membrane	739..998	CDD:279056	84/258 (33%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	125/239 (52%)
Abcb11	NP_001350421.1	AAA	29..1314	CDD:333001	508/1333 (38%)
		Interaction with HAX1. /evidence=ECO:0000250	651..674		5/41 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	662..722		15/78 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	98	1.000	Domainoid score	I7145
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S2081
OMA	1	1.010	-	-		QHG63700
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100059
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R932
SonicParanoid	1	1.000	-	-		X92
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.700