Protein Alignment Mdr49 and Abcb11

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_066302.2
• Gene: Abcb11 / 27413
• MGIID: 1351619
• Length: 1321
• Species: Mus musculus
• Alignment Length: 1336
• Identity: 509/1336 - (38%)
• Similarity: 775/1336 - (58%)
• Gaps: 94/1336 - (7%)

  Fly     5 EESRLPQAGDFQLKEGSVVDATRKYSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGE 69
            ::|||.   |.:..||:      :..:|:|||:|:..:.:|:.:..:.|.......|..:|::|.
Mouse    30 KKSRLQ---DKKKGEGA------RVGFFELFRFSSSKDNWLMFMGSVCALLHGMAQPGMIIVFGI 85

  Fly    70 FTSLLVDRTVGVGTSSPAFALP--------------MFGGGQQLTNASK----EENNQAIIDDAT 116
            .|.:.|:..:    .....::|              .|  .|.:||.:.    :.|::.|.....
Mouse    86 LTDIFVEYDI----ERQELSIPEKVCMNNTIVWINSSF--NQNMTNGTSCGLVDINSEVIKFSGI 144

  Fly   117 AFGIGSLVGSVAMFLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTE 181
            ..|:|     ||:.:|....|.|.......||.::||.:...::|.:|.|:|.:|.....|:.::
Mouse   145 YAGVG-----VAVLILGYFQIRLWVITGARQIRKMRKFYFRRIMRMEIGWFDCTSVGELNSRFSD 204

  Fly   182 DLDKLKEGIGEKIVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEK 246
            |::|:.|.|.:::.:.:..:.|.:.|::..|..|||||||:|:..|.|....:|:........|.
Mouse   205 DINKIDEAIADQMALFLQRLSTALSGLLLGFYRGWKLTLVILAVSPLIGIGAAVIGLSVAKFTEL 269

  Fly   247 ELKSYSDAANVVEEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIY 311
            |||:|:.|.::.:||.|.||||.||.|:.||.||:.|.|:.|:..|..||:..|......|.:|:
Mouse   270 ELKAYAKAGSIADEVLSSIRTVAAFGGENKEVERYEKNLMFAQRWGIWKGMVMGFFTGYMWCLIF 334

  Fly   312 LCMALAIWYGVTLILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLF 376
            .|.|||.|||..|:|||.:     |||..|:.:...||:.|.|:|.||..:|..:...:|..::|
Mouse   335 FCYALAFWYGSRLVLDEGE-----YTPGTLIQIFLCVIIAAMNIGNASSCLEIFSTGCSAASSIF 394

  Fly   377 NIIDRPSQVDPMDEKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGC 441
            ..|||...:|.|...|.:.:...|.|.|..:.|.||:||:|:||..|::.:.||:|.||||:||.
Mouse   395 QTIDRQPVMDCMSGDGYKLDRIKGEIEFHNVTFHYPSRPEVKILNNLSMVIKPGETTAFVGSSGA 459

  Fly   442 GKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSAT 506
            ||||.:||:||||||..|.|.|||.|:|:||:.|||.|||:|.||||||:|||.||||.||..||
Mouse   460 GKSTALQLIQRFYDPCEGMVTLDGHDIRSLNIRWLRDQIGIVEQEPVLFSTTIAENIRLGREEAT 524

  Fly   507 QADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSAL 571
            ..||.:||:.||.::||..||:.:||.|||.|.|:|||||||:||||||:|:|::||||.|||||
Mouse   525 MEDIVQAAKDANAYNFIMALPQQFDTLVGEGGGQMSGGQKQRVAIARALIRKPKILLLDMATSAL 589

  Fly   572 DPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELV 636
            |..||.:||.||.....|.|.:.|||||||:.:||.|:..:.|...|:||||||:||:|:|..||
Mouse   590 DNESEAKVQGALNKIQHGHTIISVAHRLSTVRSADVIIGFEHGTAVERGTHEELLERKGVYFMLV 654

  Fly   637 SITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGFRASTRRK 701
            ::..:::.|..:.| :.|:                  |..|.:.||...|..|.....|||.|::
Mouse   655 TLQSQEDNTHKETG-IKGK------------------DTTEGDTPERTFSRGSYQDSLRASIRQR 700

  Fly   702 RRSQ-----------------RRKKKKDKEV----VSKVSFTQLMKLNSPEWRFIVVGGIASVMH 745
            .:||                 ..:.:||.:|    |......:::|.|..||.:|:||.:.:.::
Mouse   701 SKSQLSHLSHEPPLAIGDHKSSYEDRKDNDVLVEEVEPAPVRRILKYNISEWPYILVGALCAAIN 765

  Fly   746 GATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTR 810
            ||..|::.|.|.......|..|.:..|:|:..:.:.||.:|.::.....||.|.|..:|..:|.|
Mouse   766 GAVTPIYSLLFSQILKTFSLVDKEQQRSEIYSMCLFFVILGCVSLFTQFLQGYNFAKSGELLTKR 830

  Fly   811 LRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFV 875
            |||..|..::.|||.:|||.:|:.|.|.:|||:|.|.||||||::||.|:.:...:.|.:::.|:
Mouse   831 LRKFGFKAMLRQDIGWFDDLKNNPGVLTTRLATDASQVQGATGSQVGMMVNSFTNIFVAVLIAFL 895

  Fly   876 FSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVL 940
            |:|:.:|:..|..|.:.||..::.:.:...|.:.|..:|:|.|:..||::|||||.|:.:|.:.:
Mouse   896 FNWKLSLVISVFFPFLALSGAVQTKMLTGFASQDKEILEKAGQITNEALSNIRTVAGIGVEGRFI 960

  Fly   941 DQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALI 1005
            ..:..::::......||....||.:|..|...|||...:..|||.|:..|.:|:..:.:|..::.
Mouse   961 KAFEVELEKSYKTAIRKANVYGLCYAFSQGISFLANSAAYRYGGYLIVYEDLNFSYVFRVVSSIA 1025

  Fly  1006 FGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTV----EKSEGDIVYENVGF 1066
            ..:..:|:..:|.|:...|.:||.|...|..|     .||...|:..    :..:|.|.:.:..|
Mouse  1026 MSATAVGRTFSYTPSYAKAKISAARFFQLLDR-----KPPIDVYSGAGEKWDNFQGKIDFIDCKF 1085

  Fly  1067 EYPTRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLD 1131
            .||:|....:|.||::::....|:|.||.||.||||.:|||.|:|||..|:|.:.|..|.:..:.
Mouse  1086 TYPSRPDIQVLNGLSVSVDPGQTLAFVGSSGCGKSTSIQLLERFYDPDQGTVMIDGHDSKKVNVQ 1150

  Fly  1132 TLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG- 1195
            .|||.:|:|||||||||.:|.:||.||:|.: ::|::..|.|||::.:|:|:.:||:.|:|.:|
Mouse  1151 FLRSNIGIVSQEPVLFDCSIMDNIKYGDNTK-EISVERAIAAAKQAQLHDFVMSLPEKYETNVGI 1214

  Fly  1196 KTSQLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTT 1260
            :.||||.|:|||||||||:||:||||:|||||||||.||||.||.|||:||.||||:.|||||:|
Mouse  1215 QGSQLSRGEKQRIAIARAIVRDPKILLLDEATSALDTESEKTVQLALDKAREGRTCIVIAHRLST 1279

  Fly  1261 VRNADLICVLKRGVVVEHGTHDELMALNKIYANLYL 1296
            ::|:|:|.|:.:|||:|.|||.:||.....|..|.:
Mouse  1280 IQNSDIIAVMSQGVVIEKGTHKKLMDQKGAYYKLVI 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	249/616 (40%)
		MdlB	720..1299	CDD:440747	230/582 (40%)
Abcb11	NP_066302.2	PTZ00265	29..1314	CDD:240339	508/1333 (38%)
		Interaction with HAX1. /evidence=ECO:0000250	651..674		5/41 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	662..722		15/78 (19%)