DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Mdr49 and mam1

DIOPT Version :9

Sequence 1:	NP_523724.2	Gene:	Mdr49 / 36428	FlyBaseID:	FBgn0004512	Length:	1302	Species:	Drosophila melanogaster
Sequence 2:	NP_001018819.2	Gene:	mam1 / 2540405	PomBaseID:	SPBC25B2.02c	Length:	1336	Species:	Schizosaccharomyces pombe

Alignment Length:	1337	Identity:	341/1337 - (25%)
Similarity:	589/1337 - (44%)	Gaps:	146/1337 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 LPQAGDFQLKEGSVVDATRKYS-YFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEFTS 72
            :|...|.:.:....:.....:| :|.||.:|.    ..|:...|:.|..||.:...|
pombe    69 IPTVVDDEFQHTEELAGVSSWSDFFYLFHFSD----IPLIFGTLIFTCLSAALEPLM-------- 121

  Fly    73 LLVDRTVGVGTSSPAF-ALPMFGGGQ-------QLTNASKEENNQAIIDDATAFGIGSLVGSVAM 129
                    ..|:...| ||..:...|       .|.|.     |..:|   |.||:.|.|.|..:
pombe   122 --------TWTTGKVFDALSQYATSQITLGKMISLINF-----NSLLI---TIFGLASCVFSFGV 170

  Fly   130 FLLITLAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYD-TSSGSNFASKMTEDLDKLKEGIGEK 193
            ..|......:|.:       |.|.|....:..:...:|. |.|.|...:.:...:...::.|...
pombe   171 RFLWQYLSAIAGK-------RARSLCFHVLSSKSSTFYSLTESKSGLVNSVDRCIQFYEKSISLP 228

  Fly   194 IVIVVFLIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVV 258
            :..:...:...:..::.:|.|.|.||||||:..|.||.....:.....|..||:.||...||:::
pombe   229 MFHIAENLAISLSCLIISFRYSWSLTLVVLASYPIIILVVGFINSFLSSAYEKDRKSSEKAASIL 293

  Fly   259 EEVFSGIRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVT 323
            |:..|.|:||...|.|:.|...|......:..:..:..........:|...:|......:|:|..
pombe   294 EKSISAIQTVIFHSMQDTEYRYFADACSTSSKSFLRFSFLDAFQGGVSQFFLYSVFFQGLWFGNH 358

  Fly   324 LILDERDLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPM 388
            |...:|....:|.|      |..:.:..|.:|....|.:..:.....:...:..:.:   ..||:
pombe   359 LATTKRVNVGQVVT------VFGSCLSVASSLQQILPAIPDLIKGKFSSHFIKTLCE---SHDPI 414

  Fly   389 D--------------EKGNRPENTAGHIRFEGIRFRYPARPDVEILKGLTVDV-LP-GQTVAFVG 437
            :              |:|         .||:.:.|.||:| |..:...:.|.| :| |:.|..:|
pombe   415 EAAKRSAAKIKSISFERG---------FRFDNVSFAYPSR-DENLFSLINVSVFIPFGELVHIIG 469

  Fly   438 ASGCGKSTLIQLMQRFYDPEAGSVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGR 502
            .||.||||.|.|:.|::.|..|::.||...|..::...|.|.|.:|.|:||:|..||.|||....
pombe   470 PSGSGKSTFISLLLRYFSPTYGNIYLDDFPLEEIDEHVLGSTITLVCQQPVIFDMTIRENIIMRN 534

  Fly   503 PSATQADIEKAARAANCHDFITRLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEA 567
            .:|:::|.|:..|.|...:|.....:.|||..  |.|.:||||:||||:||||:|..::|:|||.
pombe   535 ENASESDFEEVCRLALVDEFALTFDQSYDTPC--KEASLSGGQQQRIALARALLRDTEILILDEP 597

  Fly   568 TSALDPTSEKRVQSALELASQGPTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLY 632
            ||||||.::..|..|:....:|.||||:.|.:|.|.|.:.::.:..|.:.::...:||:    |:
pombe   598 TSALDPITKNLVMDAIRAHRKGKTTLVITHDMSQINNDELVLVIDKGHLIQRCARKELV----LF 658

  Fly   633 CEL---VSITQRKEATEADEGAVAGRPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSGF 694
            .:.   |||.::....|||...:    |...::|.::...:..|...:.....|.||..|..:..
pombe   659 EDFENNVSIDEKVLKEEADNPFI----LPNEESLLEKYWINYNESFSQLSRESLFTSLESPFTDI 719

  Fly   695 RASTRRKRRS--QRRKKKKDKEVVSKVS--------------------FTQLMKLNSPEWRFIVV 737
            .:.|...||.  ::||.:.:||...:.:                    |..:.|:....| |.::
pombe   720 ESPTIVSRRKIVEQRKLRMEKESFQETNVDQTFHLFDDKEHACSLTLIFKSIWKVKKLRW-FFLL 783

  Fly   738 GGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTT 802
            |.:.|::.||:.|::.........:....|..:  ......||:.| :...:|.......|:|:.
pombe   784 GLLTSLIQGASVPIFAYVISKCLNLFMQIDPSI--GVAFWSSMVLV-VAAGSGASYFFSHYIFSI 845

  Fly   803 AGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGALCSRLASDCSNVQGATGARVGTMLQAVATLV 867
            :........|..|...:..||.|:||...|....|...|.::.|:::....:.:..:..|....:
pombe   846 SAKIWCDHYRLLAVKVLFTQDQAWFDQIENYPLVLSKILVNNISDMRNMISSLIEEVFIAFTMAI 910

  Fly   868 VGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNG 932
            :|:...|...|:...:.:...|::||:..:.....:.:.:..:..:...:.:..:.|.|:.|:.|
pombe   911 IGIAWSFATGWRLAAVLVAVSPILCLTSRMFSYIYVSTERMCQDVVISTTSILHKTIVNLDTIKG 975

  Fly   933 LCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFALGQAAPFLAYGISMYYGGILVAEERMNYEDI 997
            ..:.....:.:...:.:...|.:|:..:..|.||:..:..:....:..|...|.:::|....|.:
pombe   976 YSVLSFFRENHKNSLRKSWEAFKRRAFWTSLGFAINNSLLYFVRALLFYCSSIFISKEFYTVEQM 1040

  Fly   998 IKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKS------- 1055
            ::|.....|...|....:...|||:.:.::..|::   |.:|.:|       ..:.||
pombe  1041 VQVLSLATFTLLMASTCIMSLPNVSASRIATSRVL---KLSSLKP-------GNLHKSGYLKFPL 1095

  Fly  1056 EGDIVYENVGFEYP-TRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVN 1119
            .|.|.::.|.|.|| :.:....|..::|:|:....||:||.|||||||.|:||.:.|.  |..:.
pombe  1096 VGKIEFDGVSFAYPDSERNHLALNNVSLSIEAREKVAIVGISGSGKSTLVELLRKTYP--SEDIY 1158

  Fly  1120 LSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFIS 1184
            :.|.|.|....:.|..|:.:|.|:|.|...||.|::.||    .|..:..:::|..|:.:...|.
pombe  1159 IDGYPLTNIDTNWLLKKVAIVDQKPHLLGSTILESLLYG----VDRDINSVMDALDKTYMTEVIQ 1219

  Fly  1185 ALPQGYDTRLGKTSQ-LSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARSG 1248
            .||.|.||.|.:.|: .||||.||:|.||||:|||::|||||.|||||.:|..::::.:.....
pombe  1220 NLPNGLDTPLLEFSKNFSGGQIQRLAFARALLRNPRLLILDECTSALDSKSSLLLEKTIQNLSC- 1283

  Fly  1249 RTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELM 1285
             |.|.|.|:.:.::.||.|.|:..|:|.|.|:.||||
pombe  1284 -TVLIITHQPSLMKLADRIIVMDSGIVKESGSFDELM 1319

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	34..640	CDD:224055	170/633 (27%)
		ABC_membrane	116..352	CDD:279056	53/236 (22%)
		ABC_MTABC3_MDL1_MDL2	402..636	CDD:213216	89/238 (37%)
		MdlB	735..1299	CDD:224055	146/560 (26%)
		ABC_membrane	739..998	CDD:279056	42/258 (16%)
		ABC_MTABC3_MDL1_MDL2	1059..1298	CDD:213216	90/229 (39%)
mam1	NP_001018819.2	MdlB	89..655	CDD:224055	166/621 (27%)
		ABC_membrane	108..372	CDD:294371	65/294 (22%)
		ABCC_MRP_Like	434..645	CDD:213195	85/213 (40%)
		MdlB	767..1328	CDD:224055	150/575 (26%)
		ABC_membrane	785..1049	CDD:294371	43/266 (16%)
		P-loop_NTPase	1099..1332	CDD:304359	90/229 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0055
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000106
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X92
TreeFam	1	0.960	-	-
	4	3.860