Protein Alignment Mdr49 and Abcb4

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_036822.1
• Gene: Abcb4 / 24891
• RGDID: 620248
• Length: 1278
• Species: Rattus norvegicus
• Alignment Length: 1311
• Identity: 557/1311 - (42%)
• Similarity: 809/1311 - (61%)
• Gaps: 79/1311 - (6%)

  Fly    13 GDFQLKEGSVVDATRK-------YSYFDLFRYSTRCERFLLVVSLLVATAASAFIPYFMIIYGEF 70
            |||:|  ||:.:.:|:       .....|||||...::..:::...:|.|..:.:|..||::||.
  Rat    16 GDFEL--GSISNQSREKKKKVNLIGPLTLFRYSDWQDKLFMLLGTAMAIAHGSGLPLMMIVFGEM 78

  Fly    71 TSLLVDRTVGVGTSSPA-FALPMFGGGQQLTNASKEENNQAIIDDATAFGIGSLVGSVAMFLLIT 134
            |...||.....  |.|. |:|.|...|:.|     ||.........:..|.|.|:.:.......|
  Rat    79 TDKFVDNAGNF--SLPVNFSLSMLNPGRIL-----EEEMTRYAYYYSGLGGGVLLAAYIQVSFWT 136

  Fly   135 LAIDLANRIALNQIDRIRKLFLEAMLRQDIAWYDTSSGSNFASKMTEDLDKLKEGIGEKIVIVVF 199
            ||       |..||.:||:.|..|:|||::.|:|....:...:::|:|:.|:.||||:|:.:...
  Rat   137 LA-------AGRQIRKIRQKFFHAILRQEMGWFDIKGTTELNTRLTDDISKISEGIGDKVGMFFQ 194

  Fly   200 LIMTFVIGIVSAFVYGWKLTLVVLSCVPFIIAATSVVARLQGSLAEKELKSYSDAANVVEEVFSG 264
            .|.||..|.:..|:.|||||||:::....:..:|:|.|::..:.::|||.:|:.|..|.||....
  Rat   195 AIATFFAGFIVGFIRGWKLTLVIMAITAILGLSTAVWAKILSTFSDKELAAYAKAGAVAEEALGA 259

  Fly   265 IRTVFAFSGQEKEKERFGKLLIPAENTGRKKGLYSGMGNALSWLIIYLCMALAIWYGVTLILDER 329
            ||||.||.||.||.||:.|.|..|:..|.||.:.:.:...:::|:||...|||.|||.||::.:.
  Rat   260 IRTVIAFGGQNKELERYQKHLENAKKIGIKKAISANISMGIAFLLIYASYALAFWYGSTLVISKE 324

  Fly   330 DLPDRVYTPAVLVIVLFAVIMGAQNLGFASPHVEAIAVATAAGQTLFNIIDRPSQVDPMDEKGNR 394
                  ||....:.|.|::::||.::|.|:|.::|...|..|...:|:|||...::|...|:|::
  Rat   325 ------YTIGNAMTVFFSILIGAFSVGQAAPCIDAFPNARGAAYVIFDIIDNNPKIDSFSERGHK 383

  Fly   395 PENTAGHIRFEGIRFRYPARPDVEILKGLTVDVLPGQTVAFVGASGCGKSTLIQLMQRFYDPEAG 459
            |::..|::.|..:.|.||:|.:::|||||.:.|..|||||.||.|||||||.:||:||.|||..|
  Rat   384 PDSIKGNLEFSDVHFSYPSRANIKILKGLNLKVKSGQTVALVGNSGCGKSTTVQLLQRLYDPTEG 448

  Fly   460 SVKLDGRDLRTLNVGWLRSQIGVVGQEPVLFATTIGENIRYGRPSATQADIEKAARAANCHDFIT 524
            ::.:||:|:|..||..||..||||.||||||:|||.|||||||.:.|..:|:||.:.||.:|||.
  Rat   449 TISIDGQDIRNFNVRCLREFIGVVSQEPVLFSTTIAENIRYGRGNVTMDEIKKAVKEANAYDFIM 513

  Fly   525 RLPKGYDTQVGEKGAQISGGQKQRIAIARALVRQPQVLLLDEATSALDPTSEKRVQSALELASQG 589
            :||:.:||.||::|||:||||||||||||||||.|::|||||||||||..||..||:||:.|.:|
  Rat   514 KLPQKFDTLVGDRGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAEVQAALDKAREG 578

  Fly   590 PTTLVVAHRLSTITNADKIVFLKDGVVAEQGTHEELMERRGLYCELVSITQRKEATEADEGAVAG 654
            .||:|:||||||:.|||.|...:|||:.|||:|.||:::.|:|..||::            ..:|
  Rat   579 RTTIVIAHRLSTVRNADVIAGFEDGVIVEQGSHSELIKKEGIYFRLVNM------------QTSG 631

  Fly   655 RPLQKSQNLSDEETDDDEEDEEEDEEPELQTSGSSRDSG-----FRASTRRKRRSQR-RKKKKDK 713
                 ||.||:|     .|.|..||    :.:|....:|     ||.||::..:|.| .:.:.|.
  Rat   632 -----SQILSEE-----FEVELSDE----KAAGGVAPNGWKARIFRNSTKKSLKSSRAHQNRLDV 682

  Fly   714 EV------VSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWGLFFGDFFGILSDGDDDVVR 772
            |.      |..|||.::::||..||.:.|||.:.::.:||..|.:.:...:...|...|||.|.:
  Rat   683 ETNELDANVPPVSFLKVLRLNKTEWPYFVVGTLCAIANGALQPAFSIILSEMIAIFGPGDDTVKQ 747

  Fly   773 AEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDERNSVGAL 837
            .:....|::|:|:|:.:.....||.:.|..||..:|||||..||..::.||:::|||.:||.|||
  Rat   748 QKCNMFSLVFLGLGVHSFFTFFLQGFTFGKAGEILTTRLRSMAFKAMLRQDMSWFDDHKNSTGAL 812

  Fly   838 CSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQTLLTLVTLPLVCLSVYLEGRFI 902
            .:|||:|.:.||||||.|:..:.|..|.|..|:::.|::.||.|||.|..:|.:.::..:|.:.:
  Rat   813 STRLATDAAQVQGATGTRLALIAQNTANLGTGIIISFIYGWQLTLLLLSVVPFIAVAGIVEMKML 877

  Fly   903 MKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIACRRKVRFRGLVFAL 967
            ..:|::.|..:|.|.::|.|||.|||||..|..||:....||:::........||....|:.|::
  Rat   878 AGNAKRDKKEMEAAGKIATEAIENIRTVVSLTQERKFESMYVEKLHGPYRNSVRKAHIYGITFSI 942

  Fly   968 GQAAPFLAYGISMYYGGILVAEERMNYEDIIKVAEALIFGSWMLGQALAYAPNVNDAILSAGRLM 1032
            .||..:.:|.....:|..|:....|.::|:|.|..|::.|:..||.|.::||:...|.|||..|.
  Rat   943 SQAFMYFSYAGCFRFGSYLIVNGHMRFKDVILVFSAIVLGAVALGHASSFAPDYAKAKLSAAYLF 1007

  Fly  1033 DLFKRTSTQPNPPQSPYNT----VEKSEGDIVYENVGFEYPTRKGTPILQGLNLTIKKSTTVALV 1093
            .||:|     .|....|:.    .:|.||.:.:..|.|.||||...|:||||:|.:||..|:|||
  Rat  1008 SLFER-----QPLIDSYSREGMWPDKFEGSVTFNEVVFNYPTRANVPVLQGLSLEVKKGQTLALV 1067

  Fly  1094 GPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLRSKLGLVSQEPVLFDRTIAENIAYG 1158
            |.||.||||.||||.|:|||::|:|.|.|..:.:..:..||::||:|||||:|||.:||:|||||
  Rat  1068 GSSGCGKSTVVQLLERFYDPMAGTVLLDGQEAKKLNVQWLRAQLGIVSQEPILFDCSIAKNIAYG 1132

  Fly  1159 NNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTSQLSGGQKQRIAIARALVRNPKILI 1222
            :|.| .||..||:.|||::|||.||..|||.|:||:| |.:||||||||||||||||:|.|::|:
  Rat  1133 DNSR-VVSQDEIVRAAKEANIHPFIETLPQKYETRVGDKGTQLSGGQKQRIAIARALIRQPRVLL 1196

  Fly  1223 LDEATSALDLESEKVVQQALDEARSGRTCLTIAHRLTTVRNADLICVLKRGVVVEHGTHDELMAL 1287
            |||||||||.|||||||:|||:||.||||:.|||||:|::|||||.|:..|.|.|||||.:|:|.
  Rat  1197 LDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVIDNGKVKEHGTHQQLLAQ 1261

  Fly  1288 NKIYANLYLMQ 1298
            ..||.::..:|
  Rat  1262 KGIYFSMVNIQ 1272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747	259/599 (43%)
		MdlB	720..1299	CDD:440747	264/584 (45%)
Abcb4	NP_036822.1	PTZ00265	29..1271	CDD:240339	549/1293 (42%)
		MdlB	42..632	CDD:440747	265/626 (42%)
		Interaction with HAX1. /evidence=ECO:0000269|PubMed:15159385	622..646		10/45 (22%)