Protein Alignment Mdr49 and Tap2

DIOPT Version :10

• Sequence 1: NP_523724.2
• Gene: Mdr49 / 36428
• FlyBaseID: FBgn0004512
• Length: 1302
• Species: Drosophila melanogaster
• Sequence 2: NP_114445.2
• Gene: Tap2 / 24812
• RGDID: 3818
• Length: 703
• Species: Rattus norvegicus
• Alignment Length: 623
• Identity: 203/623 - (32%)
• Similarity: 315/623 - (50%)
• Gaps: 79/623 - (12%)

  Fly   708 KKKKDKEVVSKVSFTQLMKLNSPEWRFIVVGGIASVMHGATFPLWG-----LFFGDFFGIL-SDG 766
            ::|:..:..::....:|::|:.|:..|::|..|...|     .:||     .:.|....|| .|.
  Rat   125 QEKEPGQENNRALMIRLLRLSKPDLPFLIVAFIFLAM-----AVWGETLIPHYSGRVIDILGGDF 184

  Fly   767 DDDVVRAEVLKISMIFVGIGLMAGLGNMLQTYMFTTAGVKMTTRLRKRAFGTIIGQDIAYFDDER 831
            |.|...:.:..:.:..||..|.||...  .:::||.:.:.:  |:|::.|.:::.||:|:|.:.:
  Rat   185 DPDAFASAIFFMCLFSVGSSLSAGCRG--GSFLFTMSRINL--RIREQLFSSLLRQDLAFFQETK 245

  Fly   832 NSVGALCSRLASDCSNVQGATGARVGTMLQAVATLVVGMVVGFVFSWQQ-----TLLTLVTLPLV 891
              .|.|.|||:||.|.:..........:|:::.     .|||..:...|     |.|:|:.|||.
  Rat   246 --TGELNSRLSSDTSLMSRWLPFNANILLRSLV-----KVVGLYYFMLQVSPRLTFLSLLDLPLT 303

  Fly   892 CLS--VY-LEGRFIMKSAQKAKASIEEASQVAVEAITNIRTVNGLCLERQVLDQYVQQIDRVDIA 953
            ..:  || ...:.::|..|..   :.:|.||..||:..::||.....|.|.:.:|.:.::|
  Rat   304 IAAEKVYNPRHQAVLKEIQDV---VAKAGQVVREAVGGLQTVRSFGAEEQEVSRYKEALER---- 361

  Fly   954 CRRKVRFRGL----------VFALGQAAPFLAYGISMYYGGILVAEERMNY----EDIIKVAEAL 1004
            ||:....|.|          |.|||.....|..|:.....|.:.....:::    |::......|
  Rat   362 CRQLWWRRDLEKELYLVIRRVMALGMQVLILNCGVQQILAGEVTRGGLLSFLLYQEEVGHHVRNL 426

  Fly  1005 IFGSWMLGQALAYAPNVNDAILSAGRLMDLFKRTSTQPNPPQSPYNTVEKSEGDIVYENVGFEYP 1069
            ::   |.|          |.:.:.|....:|.....:||.|:.......:.||.:.:::|.|.||
  Rat   427 VY---MYG----------DMLSNVGAAEKVFSYLDRRPNLPKPGTLAPPRVEGRVEFQDVSFSYP 478

  Fly  1070 TRKGTPILQGLNLTIKKSTTVALVGPSGSGKSTCVQLLLRYYDPVSGSVNLSGVPSTEFPLDTLR 1134
            :|...|:||||..|:......|||||:||||||...||...|.|..|.|.|.|.|..::....|.
  Rat   479 SRPEKPVLQGLTFTLHPGKVTALVGPNGSGKSTVAALLQNLYQPTGGKVLLDGEPLVQYDHHYLH 543

  Fly  1135 SKLGLVSQEPVLFDRTIAENIAYGNNFRDDVSMQEIIEAAKKSNIHNFISALPQGYDTRLG-KTS 1198
            .::.||.||||||..::.:|||||....:|.   :::.||:.:...:||..:..|.:|.:| :.|
  Rat   544 RQVVLVGQEPVLFSGSVKDNIAYGLRNCEDA---QVMAAAQAACADDFIGEMTNGINTEIGERGS 605

  Fly  1199 QLSGGQKQRIAIARALVRNPKILILDEATSALDLESEKVVQQALDEARS--GRTCLTIAHRLTTV 1261
            ||:.|||||:||||||||||::|||||||||||.|.|    |||...||  .||.|.|||||.||
  Rat   606 QLAVGQKQRLAIARALVRNPRVLILDEATSALDAECE----QALQTWRSQEDRTMLVIAHRLHTV 666

  Fly  1262 RNADLICVLKRGVVVEHGTHDELMALNKIYANLYLMQQ 1299
            :|||.:.|||:|.:||   ||:|.....:||  :|:||
  Rat   667 QNADQVLVLKQGQLVE---HDQLRDEQDVYA--HLVQQ 699

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Mdr49	NP_523724.2	MdlB	44..643	CDD:440747
		MdlB	720..1299	CDD:440747	200/609 (33%)
Tap2	NP_114445.2	3a01208	1..697	CDD:273363	200/619 (32%)